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Details on Person Expression of STAT3

Class:Id	BlackBoxEvent:452515
_displayName	Expression of STAT3
_doRelease	TRUE
_timestamp	2018-10-31 14:42:47
authored	[InstanceEdit:1013049] May, B, 2010-11-12
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:452990] May, B, 2010-01-15
edited	[InstanceEdit:1013049] May, B, 2010-11-12
input	[EntityWithAccessionedSequence:2888995] STAT3 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:452962] Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells [LiteratureReference:452854] Stat3 and Stat4: members of the family of signal transducers and activators of transcription [LiteratureReference:452900] LIF-induced STAT3 signaling in murine versus human embryonal carcinoma (EC) cells [LiteratureReference:453029] Maintenance of pluripotency in human embryonic stem cells is STAT3 independent [LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:2972933] Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal [LiteratureReference:5251070] LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells
modified	[InstanceEdit:561173] May, B, 2010-03-30 [InstanceEdit:1013055] May, B, 2010-11-12 [InstanceEdit:1086967] May, B, 2010-11-29 [InstanceEdit:1485617] May, B, 2011-08-12 [InstanceEdit:2889038] May, B, 2012-12-31 [InstanceEdit:2892244] May, B, 2012-12-31 [InstanceEdit:2972981] D'Eustachio, P, 2013-01-06 [InstanceEdit:3108239] May, B, 2013-02-10 [InstanceEdit:3165216] May, B, 2013-02-22 [InstanceEdit:4411347] May, B, 2013-08-23 [InstanceEdit:4420242] May, B, 2013-08-31 [InstanceEdit:5250254] May, B, 2014-01-24 [InstanceEdit:5250255] May, B, 2014-01-24 [InstanceEdit:5251098] May, B, 2014-01-31 [InstanceEdit:5638458] May, Bruce, 2014-11-15 [InstanceEdit:6800126] May, Bruce, 2015-09-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9627003] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of STAT3
output	[EntityWithAccessionedSequence:539044] STAT3 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:2972956] POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter [Homo sapiens] [BlackBoxEvent:452838] Expression of NANOG [Homo sapiens] [BlackBoxEvent:452894] Expression of SOX2 [Homo sapiens] [BlackBoxEvent:2889036] Translation of OCT4 mRNA [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:5638448] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:STAT3 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642764] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:STAT3 gene [nucleoplasm]' Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells
releaseDate	2014-03-12
reviewed	[InstanceEdit:5246708] Wang, Jianlong, 2014-01-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644718] R-HSA-452515.6
summation	[Summation:452808] The STAT3 gene is transcribed to yield mRNA and the mRNA is ...
(hasEvent)	[Pathway:500407] Individual Binding Reactions and Reactions Regulated by Pluripotency Factors [Homo sapiens] [Pathway:2892247] POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation [Homo sapiens]
(precedingEvent)	[Reaction:879941] SRC binds STAT3 [Homo sapiens] [Reaction:9835443] STAT1,STAT3 binds PKR [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783936] Update Tracker - [BlackBoxEvent:452515] Expression of STAT3 - v55:[removeCatalystActivity] [_UpdateTracker:9785846] Update Tracker - [BlackBoxEvent:452515] Expression of STAT3 - v51:[addCatalystActivity, addRegulator, add_removeInput]
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No pathways have been reviewed or authored by Expression of STAT3 (452515)