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Details on Person POU5F1 [nucleoplasm]
Class:Id EntityWithAccessionedSequence:452472
_displayName POU5F1 [nucleoplasm]
_timestamp 2014-11-20 04:17:53
compartment [Compartment:7660] nucleoplasm
created [InstanceEdit:452990] May, B, 2010-01-15
endCoordinate 360
modified [InstanceEdit:1485617] May, B, 2011-08-12 [InstanceEdit:3448660] Wu, G, 2013-05-16 [InstanceEdit:3632907] Wu, G, 2013-05-28
name POU5F1 OCT4 (POU5F1) POU domain, class 5, transcription factor 1 PO5F1_HUMAN OCT3 OCT4
referenceEntity [ReferenceGeneProduct:61960] UniProt:Q01860 POU5F1 [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:5648756] R-HSA-452472.1
startCoordinate 1
(activeUnit) [PositiveGeneExpressionRegulation:452214] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:DPPA4 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:480976] Positive gene expression regulation by 'EWSR1:OCT4:ZFP42 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5638447] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:FOXD3 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5638448] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:STAT3 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5638449] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:TDGF1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5638451] Positive gene expression regulation by 'POU5F1:STAT3:SALL4 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5638452] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5638453] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZIC3 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5638454] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:SOX2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5638455] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:EPHA1 gene [nucleoplasm]'
(hasComponent) [Complex:480182] EWSR1:OCT4:ZFP42 gene [nucleoplasm] [Homo sapiens] [Complex:480463] POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm] [Homo sapiens] [Complex:480572] POU5F1:SOX2:NANOG:SOX2 gene [nucleoplasm] [Homo sapiens] [Complex:1112611] POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene [nucleoplasm] [Homo sapiens] [Complex:2888997] POU5F1:SOX2:PIP5K1C gene [nucleoplasm] [Homo sapiens] [Complex:2888998] POU5F1:SOX2:NANOG:DKK1 gene [nucleoplasm] [Homo sapiens] [Complex:2889000] POU5F1:SOX2:NANOG:EOMES gene [nucleoplasm] [Homo sapiens] [Complex:2889001] POU5F1:SOX2:NANOG:GNG10 gene [nucleoplasm] [Homo sapiens] [Complex:2889002] POU5F1:SOX2:NANOG:TNC gene [nucleoplasm] [Homo sapiens] [Complex:2889003] POU5F1:SOX2:NANOG:STAT3 gene [nucleoplasm] [Homo sapiens]
(input) [Reaction:480185] Formation of EWSR1:OCT4 Complex at Promoters [Homo sapiens] [Reaction:480204] POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter [Homo sapiens] [Reaction:480685] POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter [Homo sapiens] [Reaction:1112609] POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter [Homo sapiens] [Reaction:2895778] POU5F1 (OCT4), STAT3 bind the SALL4 promoter [Homo sapiens] [Reaction:2972946] POU5F1 (OCT4), SOX2, NANOG Bind the TNC Promoter [Homo sapiens] [Reaction:2972947] POU5F1 (OCT4), SOX2, NANOG Bind the ORC1 Promoter [Homo sapiens] [Reaction:2972948] POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter [Homo sapiens] [Reaction:2972949] POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter [Homo sapiens] [Reaction:2972950] POU5F1 (OCT4), SOX2 Bind the PIP5K1C Promoter [Homo sapiens]
(output) [BlackBoxEvent:2889036] Translation of OCT4 mRNA [Homo sapiens] [BlackBoxEvent:9828023] Expression of POU5F1 (OCT4) in primordial germ cells [Homo sapiens]
(regulator) [PositiveGeneExpressionRegulation:452557] Positive gene expression regulation by 'POU5F1 [nucleoplasm]' [NegativeRegulation:453036] Negative regulation by 'POU5F1 [nucleoplasm]' [PositiveGeneExpressionRegulation:480920] Positive gene expression regulation by 'POU5F1 [nucleoplasm]'
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No pathways have been reviewed or authored by POU5F1 [nucleoplasm] (452472)