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Details on Person The SALL1 gene is transcribed to yield mRNA and the mRNA is ...
| Class:Id | Summation:452471 |
|---|---|
| _displayName | The SALL1 gene is transcribed to yield mRNA and the mRNA is ... |
| _timestamp | 2013-11-22 12:24:25 |
| created | [InstanceEdit:452990] May, B, 2010-01-15 |
| modified | [InstanceEdit:1101836] May, B, 2010-12-01 [InstanceEdit:2892231] May, B, 2012-12-31 [InstanceEdit:3656308] May, B, 2013-06-03 [InstanceEdit:5159238] D'Eustachio, P, 2013-11-22 |
| text | The SALL1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. SALL1 mRNA and protein are expressed in pituitary, adrenal cortex and the placenta in addition to kidney, testicular, and ovarian cells (Ma et al 2002, Chai et al. 2006). Mutations in SALL1 cause Townes-Brocks syndrome. The protein localizes to pericentric heterochromatin (Netzer et al. 2001). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the SALL1 gene and enhance transcription (Boyer et al. 2005, Fong et al. 2008). SOX2 binds a site in the SALL1 promoter adjacent to the site bound by POU5F1 (Boyer et al. 2005). SALL4 binds the promoter of the SALL1 gene and represses transcription by associating with Mi-2 (NuRD) repressor complex (Lu et al. 2009, Yang et al. 2010). |
| (summation) | [BlackBoxEvent:452958] Expression of SALL1 [Homo sapiens] |
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