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Details on Person Transcription of POU5F1 (OCT4)

Class:Id	BlackBoxEvent:452392
_displayName	Transcription of POU5F1 (OCT4)
_doRelease	TRUE
_timestamp	2018-11-20 03:46:00
authored	[InstanceEdit:1013049] May, B, 2010-11-12
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:452990] May, B, 2010-01-15
edited	[InstanceEdit:1013049] May, B, 2010-11-12
input	[EntityWithAccessionedSequence:2888984] POU5F1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:452887] Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis [LiteratureReference:452879] Comparative transcriptional profiling of two human embryonic stem cell lines [LiteratureReference:452197] Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells [LiteratureReference:452318] Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells [LiteratureReference:452588] Stably transfected human embryonic stem cell clones express OCT4-specific green fluorescent protein and maintain self-renewal and pluripotency [LiteratureReference:453016] The transcriptome profile of human embryonic stem cells as defined by SAGE [LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [LiteratureReference:452255] Induced pluripotent stem cell lines derived from human somatic cells [LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:453038] Characterization of human embryonic stem cell lines by the International Stem Cell Initiative [LiteratureReference:452756] A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas [LiteratureReference:452744] Characterization and gene expression profiling of five new human embryonic stem cell lines derived in Taiwan [LiteratureReference:480746] Reprogramming towards pluripotency requires AID-dependent DNA demethylation [LiteratureReference:480659] Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions [LiteratureReference:500365] Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells [LiteratureReference:994184] A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells [LiteratureReference:1101850] Oct-4 mRNA and protein expression during human preimplantation development [LiteratureReference:1059672] A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity [LiteratureReference:480737] Zfp206 is a transcription factor that controls pluripotency of embryonic stem cells [LiteratureReference:2972933] Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal
modified	[InstanceEdit:480249] May, B, 2010-01-27 [InstanceEdit:500370] May, B, 2010-02-03 [InstanceEdit:561173] May, B, 2010-03-30 [InstanceEdit:1013055] May, B, 2010-11-12 [InstanceEdit:1080831] May, B, 2010-11-29 [InstanceEdit:1086967] May, B, 2010-11-29 [InstanceEdit:1101836] May, B, 2010-12-01 [InstanceEdit:1112614] May, B, 2010-12-06 [InstanceEdit:2889038] May, B, 2012-12-31 [InstanceEdit:2892244] May, B, 2012-12-31 [InstanceEdit:2972981] D'Eustachio, P, 2013-01-06 [InstanceEdit:3108239] May, B, 2013-02-10 [InstanceEdit:3165216] May, B, 2013-02-22 [InstanceEdit:4411347] May, B, 2013-08-23 [InstanceEdit:4420242] May, B, 2013-08-31 [InstanceEdit:5163243] D'Eustachio, P, 2013-11-23 [InstanceEdit:5246709] May, B, 2014-01-22 [InstanceEdit:5246733] May, B, 2014-01-23 [InstanceEdit:5638458] May, Bruce, 2014-11-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9629283] May, Bruce, 2018-11-20 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Transcription of POU5F1 (OCT4)
output	[EntityWithAccessionedSequence:500358] POU5F1 mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:1112609] POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter [Homo sapiens] [BlackBoxEvent:452838] Expression of NANOG [Homo sapiens] [BlackBoxEvent:452894] Expression of SOX2 [Homo sapiens] [BlackBoxEvent:2889036] Translation of OCT4 mRNA [Homo sapiens] [BlackBoxEvent:8939375] Translation of FOXP1 mRNA (ES-specific isoform) [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:453022] Positive gene expression regulation by 'NR5A1 [nucleoplasm]' [PositiveGeneExpressionRegulation:480862] Positive gene expression regulation by 'EPAS1 [nucleoplasm]' [PositiveGeneExpressionRegulation:5638452] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641472] Positive gene expression regulation by 'NR5A1 [nucleoplasm]' Transcriptional regulation of human Oct4 by steroidogenic factor-1 [RegulationReference:9642305] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene [nucleoplasm]' Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis [RegulationReference:9642917] Positive gene expression regulation by 'EPAS1 [nucleoplasm]' Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
releaseDate	2014-03-12
reviewed	[InstanceEdit:5246708] Wang, Jianlong, 2014-01-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644557] R-HSA-452392.5
summation	[Summation:500363] The POU5F1 (OCT4) gene is transcribed to yield mRNA and the ...
(hasEvent)	[Pathway:452723] Transcriptional regulation of pluripotent stem cells [Homo sapiens] [Pathway:500407] Individual Binding Reactions and Reactions Regulated by Pluripotency Factors [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:452763] Expression of N-Myc (MYCN) [Homo sapiens] [Reaction:480185] Formation of EWSR1:OCT4 Complex at Promoters [Homo sapiens] [BlackBoxEvent:480788] Expression of ZSCAN10 (ZNF206) [Homo sapiens] [Reaction:500366] LIN28 binds POU5F1 (OCT4) mRNA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778403] Update Tracker - [BlackBoxEvent:452392] Transcription of POU5F1 (OCT4) - v68:[removeCatalystActivity] [_UpdateTracker:9785666] Update Tracker - [BlackBoxEvent:452392] Transcription of POU5F1 (OCT4) - v51:[addCatalystActivity, addRegulator, add_removeInput]
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No pathways have been reviewed or authored by Transcription of POU5F1 (OCT4) (452392)