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Details on Person Expression of TGF beta 4 (LEFTY2)

Class:Id	BlackBoxEvent:452384
_displayName	Expression of TGF beta 4 (LEFTY2)
_doRelease	FALSE
_timestamp	2018-10-31 14:48:22
authored	[InstanceEdit:1013049] May, B, 2010-11-12
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:452990] May, B, 2010-01-15
edited	[InstanceEdit:1013049] May, B, 2010-11-12
input	[Complex:2889027] OCT4:SOX2:NANOG:LEFTY2 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:452307] Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells [LiteratureReference:452948] In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach [LiteratureReference:1101843] Distinct tumor specific expression of TGFB4 (ebaf)*, a novel human gene of the TGF-beta superfamily
modified	[InstanceEdit:561173] May, B, 2010-03-30 [InstanceEdit:1013055] May, B, 2010-11-12 [InstanceEdit:1086967] May, B, 2010-11-29 [InstanceEdit:1101836] May, B, 2010-12-01 [InstanceEdit:2889038] May, B, 2012-12-31 [InstanceEdit:2972981] D'Eustachio, P, 2013-01-06 [InstanceEdit:3108239] May, B, 2013-02-10 [InstanceEdit:3165216] May, B, 2013-02-22 [InstanceEdit:4411347] May, B, 2013-08-23 [InstanceEdit:4420242] May, B, 2013-08-31 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9627004] May, Bruce, 2018-10-31
name	Expression of TGF beta 4 (LEFTY2)
output	[EntityWithAccessionedSequence:114708] LEFTY2(22-366) [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:2972963] POU5F1 (OCT4), SOX2, NANOG bind the LEFTY2 promoter [Homo sapiens] [BlackBoxEvent:452838] Expression of NANOG [Homo sapiens] [BlackBoxEvent:452894] Expression of SOX2 [Homo sapiens] [BlackBoxEvent:2889036] Translation of OCT4 mRNA [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8908571] R-HSA-452384.1
summation	[Summation:452807] The LEFTY2 (TGF beta 4) gene is transcribed to yield mRNA an...
(hasEvent)	[Pathway:500407] Individual Binding Reactions and Reactions Regulated by Pluripotency Factors [Homo sapiens]
(precedingEvent)	[Reaction:1181351] LEFTY binds the EGF-CFC coreceptor in the NODAL receptor [Homo sapiens] [Reaction:1181352] LEFTY binds NODAL [Homo sapiens]
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No pathways have been reviewed or authored by Expression of TGF beta 4 (LEFTY2) (452384)