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Details on Person Expression of TBXT (T, Brachyury) in the primitive streak

Class:IdBlackBoxEvent:452331
_displayNameExpression of TBXT (T, Brachyury) in the primitive streak
_doReleaseTRUE
_timestamp2022-08-06 02:59:22
authored[InstanceEdit:1013049] May, B, 2010-11-12
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:452990] May, B, 2010-01-15
edited[InstanceEdit:1013049] May, B, 2010-11-12
inferredFrom
input[EntityWithAccessionedSequence:2888965] TBXT gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:452679] Robust generation of hemangioblastic progenitors from human embryonic stem cells
[LiteratureReference:452664] Analysis of the temporal and concentration-dependent effects of BMP-4, VEGF, and TPO on development of embryonic stem cell-derived mesoderm and blood progenitors in a defined, serum-free media
[LiteratureReference:452440] Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells
[LiteratureReference:9754295] TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes
[LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells
[LiteratureReference:9757060] β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4
modified[InstanceEdit:1013055] May, B, 2010-11-12
[InstanceEdit:1086967] May, B, 2010-11-29
[InstanceEdit:1101836] May, B, 2010-12-01
[InstanceEdit:2889038] May, B, 2012-12-31
[InstanceEdit:2892244] May, B, 2012-12-31
[InstanceEdit:3108239] May, B, 2013-02-10
[InstanceEdit:3165216] May, B, 2013-02-22
[InstanceEdit:4411347] May, B, 2013-08-23
[InstanceEdit:4420242] May, B, 2013-08-31
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9627004] May, Bruce, 2018-10-31
[InstanceEdit:9734308] May, Bruce, 2021-06-16
[InstanceEdit:9750924] May, Bruce, 2021-08-17
[InstanceEdit:9754311] May, Bruce, 2021-09-23
[InstanceEdit:9754494] May, Bruce, 2021-09-28
[InstanceEdit:9760203] May, Bruce, 2021-12-15
[InstanceEdit:9760369] May, Bruce, 2021-12-16
[InstanceEdit:9773647] May, Bruce, 2022-05-08
[InstanceEdit:9794984] May, Bruce, 2022-07-25
[InstanceEdit:9795001] May, Bruce, 2022-07-25
[InstanceEdit:9795002] May, Bruce, 2022-07-25
[InstanceEdit:9796184] May, Bruce, 2022-08-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameExpression of TBXT (T, Brachyury) in the primitive streak
output[EntityWithAccessionedSequence:452976] TBXT [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:453036] Negative regulation by 'POU5F1 [nucleoplasm]'
[PositiveGeneExpressionRegulation:9754248] Positive gene expression regulation by 'LEF1,TCF7:CTNNB1:NANOG:TBPL2:TBXT gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9754242] Positive gene expression regulation by 'BMP4 dimer [extracellular region]'
regulationReference[RegulationReference:9754276] Positive gene expression regulation by 'BMP4 dimer [extracellular region]' Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells
releaseDate2022-06-09
reviewed[InstanceEdit:9773645] Tam, Patrick P L, 2022-05-08
[InstanceEdit:9794593] Probst, Simone, 2022-07-18
[InstanceEdit:9796183] Zissel, Lea, 2022-07-18
[InstanceEdit:9796182] Salehin, Nazmus, 2022-05-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8906666] R-HSA-452331.3
summation[Summation:452550] The TBXT (T, Brachyury) gene is transcribed to yield mRNA an...
(hasEvent)[Pathway:500407] Individual Binding Reactions and Reactions Regulated by Pluripotency Factors [Homo sapiens]
[Pathway:9754189] Germ layer formation at gastrulation [Homo sapiens]
(precedingEvent)[Reaction:9733781] EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene [Homo sapiens]
[Reaction:9756661] EOMES and TBXT bind the SOX2 gene [Homo sapiens]
[Reaction:9756666] EOMES and TBXT (T, Brachyury) bind the SNAI1 gene [Homo sapiens]
[Reaction:9756670] EOMES and TBXT bind the POU5F1 (OCT4) gene [Homo sapiens]
[Reaction:9756671] EOMES and TBXT bind the NANOG gene [Homo sapiens]
[BlackBoxEvent:9793383] Expression of TBX6 in paraxial mesoderm [Homo sapiens]
[BlackBoxEvent:9793921] Expression of DLL1 in paraxial mesoderm [Homo sapiens]
[BlackBoxEvent:9796300] Expression of NOTO in axial mesoderm [Homo sapiens]
(updatedInstance)[_UpdateTracker:9846995] Update Tracker - [BlackBoxEvent:452331] Expression of TBXT (T, Brachyury) in the primitive streak - v82:[addLiteratureReference, modifyText]
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