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Details on Person The FRAT2 gene is transcribed to yield mRNA and the mRNA is ...
| Class:Id | Summation:452249 |
|---|---|
| _displayName | The FRAT2 gene is transcribed to yield mRNA and the mRNA is ... |
| _timestamp | 2013-11-22 12:22:39 |
| created | [InstanceEdit:452990] May, B, 2010-01-15 |
| modified | [InstanceEdit:1101836] May, B, 2010-12-01 [InstanceEdit:2892231] May, B, 2012-12-31 [InstanceEdit:3656308] May, B, 2013-06-03 [InstanceEdit:5159238] D'Eustachio, P, 2013-11-22 |
| text | The FRAT2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. FRAT2 is expressed in a broad range of tissues, is upregulated in some cancers, and is downregulated during differentiation of the human embryonal carcinoma cell line, NT2/D1 (Saitoh et al. 2001, Freemantle et al. 2002, Snow et al. 2009). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the FRAT2 gene and enhance transcription (Boyer et al. 2005, Babaie et al. 2007, Chavez et al. 2009). The binding site of POU5F1 is not adjacent to the binding site of SOX2 (Boyer et al. 2005). FRAT2 positively regulates WNT signaling (Saitoh et al. 2001). |
| (summation) | [BlackBoxEvent:453070] Expression of FRAT2 [Homo sapiens] |
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No pathways have been reviewed or authored by The FRAT2 gene is transcribed to yield mRNA and the mRNA is ... (452249)
