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Details on Person p-STAT5 dimerizes

Class:Id	Reaction:452102
_displayName	p-STAT5 dimerizes
_doRelease	TRUE
_timestamp	2018-08-07 17:29:06
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:452117] Jupe, S, 2010-01-15
edited	[InstanceEdit:924611] Jupe, S, 2010-08-06
inferredFrom	[Reaction:2730593] Phosphorylated Stat5 dimerizes [Mus musculus]
input	[DefinedSet:507929] p-STAT5A, p-STAT5B [cytosol] [Homo sapiens] [DefinedSet:507929] p-STAT5A, p-STAT5B [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:507789] IL-2 and IL-7 induce heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblasts [LiteratureReference:452098] Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity
modified	[InstanceEdit:507790] Jupe, S, 2010-02-08 [InstanceEdit:507917] Jupe, S, 2010-02-09 [InstanceEdit:622266] Jupe, S, 2010-04-22 [InstanceEdit:912299] Jupe, S, 2010-07-08 [InstanceEdit:912307] Jupe, S, 2010-07-08 [InstanceEdit:918253] Jupe, S, 2010-08-02 [InstanceEdit:921161] Jupe, S, 2010-08-05 [InstanceEdit:926765] Jupe, S, 2010-08-06 [InstanceEdit:941871] Jupe, S, 2010-09-06 [InstanceEdit:1168907] Jupe, S, 2011-01-10 [InstanceEdit:1172024] Jupe, S, 2011-01-20 [InstanceEdit:1233244] Jupe, S, 2011-03-17 [InstanceEdit:1248024] Jupe, S, 2011-04-11 [InstanceEdit:1576229] Jupe, S, 2011-09-07 [InstanceEdit:2752153] May, B, 2012-12-08 [InstanceEdit:2883082] May, B, 2012-12-27 [InstanceEdit:4420241] May, B, 2013-08-31 [InstanceEdit:6785154] Jupe, Steve, 2015-06-25 [InstanceEdit:8983468] Jupe, Steve, 2017-03-23 [InstanceEdit:9020896] Duenas, Corina, 2017-09-11 [InstanceEdit:9020916] Duenas, Corina, 2017-09-11 [InstanceEdit:9021133] Duenas, Corina, 2017-09-14 [InstanceEdit:9021822] Duenas, Corina, 2017-09-21 [InstanceEdit:9021931] Duenas, Corina, 2017-09-21 [InstanceEdit:9022103] Duenas, Corina, 2017-09-21 [InstanceEdit:9025966] Jupe, Steve, 2017-10-16 [InstanceEdit:9025991] Jupe, Steve, 2017-10-16 [InstanceEdit:9032255] Orlic-Milacic, Marija, 2017-12-08 [InstanceEdit:9032271] Orlic-Milacic, Marija, 2017-12-08 [InstanceEdit:9038225] May, Bruce, 2018-02-23 [InstanceEdit:9615471] May, Bruce, 2018-08-07 [InstanceEdit:9615472] May, Bruce, 2018-08-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-STAT5 dimerizes
output	[Complex:507919] p-STAT5 dimer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:6785165] p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B [Homo sapiens] [BlackBoxEvent:1295540] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 [Homo sapiens] [Reaction:921155] p-STAT5 dissociates from the receptor complex [Homo sapiens] [Reaction:879909] Activation of STAT5a/b by JAK2 [Homo sapiens] [Reaction:919404] Phosphorylated STAT5 is released [Homo sapiens] [Reaction:452097] Recruited STAT5 is phosphorylated [Homo sapiens] [Reaction:9012651] p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 [Homo sapiens] [Reaction:9012650] JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:1213492] Villarino, A, 2011-02-11 [InstanceEdit:1233246] Dooms, H, 2011-03-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104394] R-HSA-452102.7
summation	[Summation:9615467] Phosphorylated STAT5A and STAT5B form homodimers and heterod...
(hasEvent)	[Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling [Homo sapiens] [Pathway:982772] Growth hormone receptor signaling [Homo sapiens] [Pathway:1266695] Interleukin-7 signaling [Homo sapiens] [Pathway:2586552] Signaling by Leptin [Homo sapiens] [Pathway:9020558] Interleukin-2 signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:507937] STAT5 dimers translocate to the nucleus [Homo sapiens] [Pathway:5602780] JAK3 deficiency causes SCID (IL7R) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779253] Update Tracker - [Reaction:452102] p-STAT5 dimerizes - v66:[add_removeSummation, removeLiteratureReference] [_UpdateTracker:9780313] Update Tracker - [Reaction:452102] p-STAT5 dimerizes - v63:[modifyText] [_UpdateTracker:9781056] Update Tracker - [Reaction:452102] p-STAT5 dimerizes - v61:[modifyText] [_UpdateTracker:9787226] Update Tracker - [Reaction:452102] p-STAT5 dimerizes - v46:[modifyText] [_UpdateTracker:9789637] Update Tracker - [Reaction:452102] p-STAT5 dimerizes - v37:[modifyText] [_UpdateTracker:9789970] Update Tracker - [Reaction:452102] p-STAT5 dimerizes - v36:[modifyText] [_UpdateTracker:9790180] Update Tracker - [Reaction:452102] p-STAT5 dimerizes - v35:[modifyText]
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