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Details on Person DO NOT RELEASE - LCK phosphorylates multiple tyrosines of IL2RB

Class:Id	Reaction:452099
_displayName	DO NOT RELEASE - LCK phosphorylates multiple tyrosines of IL2RB
_doRelease	FALSE
_timestamp	2016-07-15 23:50:25
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity	[CatalystActivity:507933] non-membrane spanning protein tyrosine kinase activity of LCK [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:452117] Jupe, S, 2010-01-15
edited	[InstanceEdit:924611] Jupe, S, 2010-08-06
input	[Complex:451920] IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:452113] Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association
modified	[InstanceEdit:507790] Jupe, S, 2010-02-08 [InstanceEdit:507900] Jupe, S, 2010-02-09 [InstanceEdit:507917] Jupe, S, 2010-02-09 [InstanceEdit:539055] Jupe, S, 2010-03-09 [InstanceEdit:918253] Jupe, S, 2010-08-02 [InstanceEdit:926764] Jupe, S, 2010-08-06 [InstanceEdit:941875] Jupe, S, 2010-09-06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1168657] Jupe, S, 2011-01-05 [InstanceEdit:1213485] Jupe, S, 2011-02-11 [InstanceEdit:1233244] Jupe, S, 2011-03-17 [InstanceEdit:1248024] Jupe, S, 2011-04-11 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	DO NOT RELEASE - LCK phosphorylates multiple tyrosines of IL2RB
output	[Complex:507935] IL2R trimer (p-Y355,358,361,392,510 beta subunit):p-JAK1:JAK3 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
reviewed	[InstanceEdit:1213492] Villarino, A, 2011-02-11 [InstanceEdit:1233246] Dooms, H, 2011-03-17
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8919778] R-HSA-452099.1
summation	[Summation:452110] Following IL2R stimulation by IL2, IL2RB and IL2RG chains b...
(hasEvent)	[Pathway:451927] Interleukin-2 family signaling [Homo sapiens]
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