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Details on Person Phosphorylation of IL2RB Y338 enables SHC recruitment

Class:Id	Reaction:452091
_displayName	Phosphorylation of IL2RB Y338 enables SHC recruitment
_doRelease	TRUE
_timestamp	2017-12-08 18:23:23
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:452117] Jupe, S, 2010-01-15
edited	[InstanceEdit:924611] Jupe, S, 2010-08-06
input	[Complex:452119] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:74680] SHC1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:452103] Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation [LiteratureReference:452092] Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling [LiteratureReference:453110] Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association
modified	[InstanceEdit:453095] Jupe, S, 2010-01-18 [InstanceEdit:507900] Jupe, S, 2010-02-09 [InstanceEdit:507917] Jupe, S, 2010-02-09 [InstanceEdit:918253] Jupe, S, 2010-08-02 [InstanceEdit:926765] Jupe, S, 2010-08-06 [InstanceEdit:941874] Jupe, S, 2010-09-06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1168657] Jupe, S, 2011-01-05 [InstanceEdit:1213499] Jupe, S, 2011-02-11 [InstanceEdit:1233244] Jupe, S, 2011-03-17 [InstanceEdit:9020559] Duenas, Corina, 2017-09-07 [InstanceEdit:9032271] Orlic-Milacic, Marija, 2017-12-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of IL2RB Y338 enables SHC recruitment
output	[Complex:452095] IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:452122] JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB [Homo sapiens] [Reaction:451942] Within the IL-2R complex JAK3 phosphorylates JAK1 [Homo sapiens]
releaseDate	2011-03-15
reviewed	[InstanceEdit:1213492] Villarino, A, 2011-02-11 [InstanceEdit:1233246] Dooms, H, 2011-03-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1225079] R-HSA-452091.4
summation	[Summation:453109] Phosphorylation of IL2RB Y338 creates a binding site for the...
(hasEvent)	[Pathway:9020558] Interleukin-2 signaling [Homo sapiens]
(precedingEvent)	[Reaction:452100] SHC1 bound to IL2 receptor is phosphorylated [Homo sapiens]
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