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Details on Person arginine + H2O => ornithine + urea [ARG2]

Class:Id	Reaction:452036
_displayName	arginine + H2O => ornithine + urea [ARG2]
_doRelease	TRUE
_timestamp	2026-05-01 21:31:06
authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:452020] arginase activity of ARG2 trimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643729] arginase activity of ARG2 trimer [mitochondrial matrix] Human arginase II: crystal structure and physiological role in male and female sexual arousal
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:452030] D'Eustachio, P, 2010-01-14
crossReference	[DatabaseIdentifier:9988057] RHEA:20570
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input	[SimpleEntity:374064] L-Arg [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:452002] Human arginase II: crystal structure and physiological role in male and female sexual arousal [LiteratureReference:451996] Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line [LiteratureReference:451994] The human arginases and arginase deficiency
modified	[InstanceEdit:452049] D'Eustachio, P, 2010-01-14 [InstanceEdit:1080818] D'Eustachio, P, 2010-11-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9988059] D'Eustachio, Peter, 2026-05-01
name	arginine + H2O => ornithine + urea [ARG2] L-arginine + H2O => urea + L-ornithine
output	[SimpleEntity:113585] L-Orn [mitochondrial matrix] [SimpleEntity:374061] Urea [mitochondrial matrix]
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104716] R-HSA-452036.4
summation	[Summation:452001] Arginase 2 (ARG2) trimer catalyzes the hydrolysis of arginin...
(hasEvent)	[Pathway:70635] Urea cycle [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9964781] Update Tracker - [Reaction:452036] arginine + H2O => ornithine + urea [ARG2] - v94:[modifyText]
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No pathways have been reviewed or authored by arginine + H2O => ornithine + urea [ARG2] (452036)