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Details on Person IL2RG binds JAK3

Class:Id	Reaction:451895
_displayName	IL2RG binds JAK3
_doRelease	TRUE
_timestamp	2020-06-10 15:18:20
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:451894] Jupe, S, 2010-01-14
edited	[InstanceEdit:924611] Jupe, S, 2010-08-06 [InstanceEdit:9607062] Jassal, Bijay, 2018-04-27
input	[EntityWithAccessionedSequence:449139] IL2RG [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:451893] JAK3 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1213489] Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation [LiteratureReference:451906] Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta
modified	[InstanceEdit:918253] Jupe, S, 2010-08-02 [InstanceEdit:926764] Jupe, S, 2010-08-06 [InstanceEdit:941875] Jupe, S, 2010-09-06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1168657] Jupe, S, 2011-01-05 [InstanceEdit:1213487] Jupe, S, 2011-02-11 [InstanceEdit:1233244] Jupe, S, 2011-03-17 [InstanceEdit:1295755] Jupe, S, 2011-05-18 [InstanceEdit:1963544] Jupe, S, 2011-11-03 [InstanceEdit:1963554] Jupe, S, 2011-11-03 [InstanceEdit:6785154] Jupe, Steve, 2015-06-25 [InstanceEdit:8983854] Jupe, Steve, 2017-03-30 [InstanceEdit:9015709] Duenas, Corina, 2017-08-11 [InstanceEdit:9025936] Jupe, Steve, 2017-10-16 [InstanceEdit:9607065] Jassal, Bijay, 2018-04-30 [InstanceEdit:9691254] Jassal, Bijay, 2020-06-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL2RG binds JAK3
output	[Complex:451911] IL2RG:JAK3 [plasma membrane] [Homo sapiens]
regulatedBy	[NegativeRegulation:9691253] Negative regulation by 'JAK3:JAK3 inhibitors [cytosol]'
regulationReference	[RegulationReference:9691255] Negative regulation by 'JAK3:JAK3 inhibitors [cytosol]' Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases
releaseDate	2011-03-15
reviewed	[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28 [InstanceEdit:9607063] Limon, Paula, 2018-04-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1224928] R-HSA-451895.8
summation	[Summation:1213491] Cytokine receptor common gamma subunit (IL2RG, IL-2 receptor...
(hasEvent)	[Pathway:1266695] Interleukin-7 signaling [Homo sapiens] [Pathway:6785807] Interleukin-4 and Interleukin-13 signaling [Homo sapiens] [Pathway:8985947] Interleukin-9 signaling [Homo sapiens] [Pathway:9020558] Interleukin-2 signaling [Homo sapiens]
(normalReaction)	[FailedReaction:5602695] Defective JAK3 does not bind IL2RG [Homo sapiens] [FailedReaction:5673698] Defective IL2RG does not bind JAK3 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:449115] IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 [Homo sapiens] [Reaction:449958] IL7:IL7R:JAK1 binds IL2RG:JAK3 [Homo sapiens] [Reaction:450063] Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit [Homo sapiens] [Reaction:6786092] IL4:IL4R:JAK2 binds IL2RG:JAK3 [Homo sapiens] [Reaction:8963734] IL9 binds IL9R:JAK1 and IL2RG:JAK3 [Homo sapiens] [BlackBoxEvent:8983298] IL15 binds IL2RB:JAK1 and IL2RG:JAK3 [Homo sapiens] [BlackBoxEvent:9006844] IL21:IL21R:JAK1 binds IL2RG:JAK3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776863] Update Tracker - [Reaction:451895] IL2RG binds JAK3 - v74:[addRegulator] [_UpdateTracker:9779587] Update Tracker - [Reaction:451895] IL2RG binds JAK3 - v65:[modifyText] [_UpdateTracker:9780399] Update Tracker - [Reaction:451895] IL2RG binds JAK3 - v63:[add_removeLiteratureReference, modifyText] [_UpdateTracker:9780856] Update Tracker - [Reaction:451895] IL2RG binds JAK3 - v62:[modifyText] [_UpdateTracker:9781498] Update Tracker - [Reaction:451895] IL2RG binds JAK3 - v61:[modifyText]
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