Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person JAK3 [cytosol]

Class:IdEntityWithAccessionedSequence:451893
_displayNameJAK3 [cytosol]
_timestamp2010-12-02 14:44:44
compartment[Compartment:70101] cytosol
created[InstanceEdit:451894] Jupe, S, 2010-01-14
endCoordinate1124
nameJAK3
Tyrosine-protein kinase JAK3
JAK3_HUMAN
Janus kinase 3
referenceEntity[ReferenceGeneProduct:57649] UniProt:P52333 JAK3 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1106544] R-HSA-451893.1
startCoordinate1
(activeUnit)[CatalystActivity:451931] protein tyrosine kinase activity of IL2:IL2R trimer:JAK1:JAK3 [plasma membrane]
(hasCandidate)[CandidateSet:919399] STAT3 kinase candidates [cytosol] [Homo sapiens]
[CandidateSet:1295513] JAK1:JAK3 [cytosol] [Homo sapiens]
[CandidateSet:8987151] JAK2, JAK3 [cytosol] [Homo sapiens]
(hasComponent)[Complex:451911] IL2RG:JAK3 [plasma membrane] [Homo sapiens]
[Complex:507935] IL2R trimer (p-Y355,358,361,392,510 beta subunit):p-JAK1:JAK3 [plasma membrane] [Homo sapiens]
[Complex:508510] JAK3:p-PYK2 [cytosol] [Homo sapiens]
[Complex:508512] JAK3:PYK2 [cytosol] [Homo sapiens]
[Complex:6786057] p-Y-IL2RG:JAK3 [plasma membrane] [Homo sapiens]
[Complex:9678869] JAK3:JAK3 inhibitors [cytosol] [Homo sapiens]
[Complex:9701478] Active ALK:JAK3 [plasma membrane] [Homo sapiens]
(input)[Reaction:451895] IL2RG binds JAK3 [Homo sapiens]
[Reaction:508513] PTK2B binds JAK3 [Homo sapiens]
[Reaction:9679028] JAK3 binds JAK3 inhibitors [Homo sapiens]
[Reaction:9701485] Active ALK binds JAK3 [Homo sapiens]
(normalEntity)[EntityFunctionalStatus:5602621] loss_of_function of JAK3 variants [cytosol]
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No pathways have been reviewed or authored by JAK3 [cytosol] (451893)