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Details on Person Diagram of Cell Cycle Checkpoints
| Class:Id | PathwayDiagram:451785 |
|---|---|
| _displayName | Diagram of Cell Cycle Checkpoints |
| _timestamp | 2025-04-02 17:37:07 |
| created | [InstanceEdit:451782] Matthews, L, 2010-01-12 |
| height | 1791 |
| modified | [InstanceEdit:1679954] Wu, G, 2011-10-20 [InstanceEdit:1924681] Rothfels, K, 2011-11-02 [InstanceEdit:3786261] Orlic-Milacic, M, 2013-07-04 [InstanceEdit:5216627] D'Eustachio, Peter, 2013-12-17 [InstanceEdit:5216628] D'Eustachio, Peter, 2013-12-17 [InstanceEdit:5671760] Orlic-Milacic, Marija, 2015-02-02 [InstanceEdit:6792749] Orlic-Milacic, Marija, 2015-08-26 [InstanceEdit:6810448] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:6810567] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:8858384] Orlic-Milacic, Marija, 2016-02-18 [InstanceEdit:8858385] Orlic-Milacic, Marija, 2016-02-18 [InstanceEdit:8861629] Orlic-Milacic, Marija, 2016-02-19 [InstanceEdit:8932870] Orlic-Milacic, Marija, 2016-07-29 [InstanceEdit:8932871] Orlic-Milacic, Marija, 2016-07-29 [InstanceEdit:8932872] Orlic-Milacic, Marija, 2016-07-29 [InstanceEdit:8944697] Rothfels, Karen, 2016-11-04 [InstanceEdit:8948943] Matthews, Lisa, 2016-11-18 [InstanceEdit:8985821] Rothfels, Karen, 2017-04-20 [InstanceEdit:8985849] Rothfels, Karen, 2017-04-20 [InstanceEdit:8985851] Rothfels, Karen, 2017-04-20 [InstanceEdit:8986074] Rothfels, Karen, 2017-04-21 [InstanceEdit:8986080] Rothfels, Karen, 2017-04-21 [InstanceEdit:8986251] Rothfels, Karen, 2017-04-24 [InstanceEdit:8986282] Rothfels, Karen, 2017-04-24 [InstanceEdit:8986372] Rothfels, Karen, 2017-04-25 [InstanceEdit:8986395] Rothfels, Karen, 2017-04-26 [InstanceEdit:9006450] Orlic-Milacic, Marija, 2017-05-16 [InstanceEdit:9029990] Orlic-Milacic, Marija, 2017-11-23 [InstanceEdit:9032261] Matthews, Lisa, 2017-12-08 [InstanceEdit:9635363] Orlic-Milacic, Marija, 2019-01-28 [InstanceEdit:9645301] Orlic-Milacic, Marija, 2019-05-08 [InstanceEdit:9749044] Matthews, Lisa, 2021-07-29 [InstanceEdit:9938646] Orlic-Milacic, Marija, 2025-02-18 [InstanceEdit:9941615] Orlic-Milacic, Marija, 2025-03-10 [InstanceEdit:9941769] Orlic-Milacic, Marija, 2025-03-10 [InstanceEdit:9941780] Orlic-Milacic, Marija, 2025-03-10 [InstanceEdit:9941802] Orlic-Milacic, Marija, 2025-03-11 [InstanceEdit:9941811] Orlic-Milacic, Marija, 2025-03-11 [InstanceEdit:9941845] Orlic-Milacic, Marija, 2025-03-11 [InstanceEdit:9942586] Orlic-Milacic, Marija, 2025-03-17 [InstanceEdit:9943648] Orlic-Milacic, Marija, 2025-03-31 [InstanceEdit:9943671] Orlic-Milacic, Marija, 2025-03-31 [InstanceEdit:9943682] Orlic-Milacic, Marija, 2025-03-31 [InstanceEdit:9943683] Orlic-Milacic, Marija, 2025-03-31 [InstanceEdit:9943696] Orlic-Milacic, Marija, 2025-03-31 [InstanceEdit:9943700] Orlic-Milacic, Marija, 2025-03-31 [InstanceEdit:9943719] Orlic-Milacic, Marija, 2025-03-31 [InstanceEdit:9943722] Orlic-Milacic, Marija, 2025-03-31 [InstanceEdit:9943744] Orlic-Milacic, Marija, 2025-03-31 [InstanceEdit:9943745] Orlic-Milacic, Marija, 2025-03-31 [InstanceEdit:9944014] Orlic-Milacic, Marija, 2025-04-01 [InstanceEdit:9944046] Orlic-Milacic, Marija, 2025-04-02 |
| representedPathway | [Pathway:69620] Cell Cycle Checkpoints [Homo sapiens] |
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bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1080" reactomeId="3209186" position="2655 1485" bounds="2610 1467 90 36" textPosition="2612 1467" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PolyUb-TP53 Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1081" reactomeId="68524" position="2339 1277" bounds="2310 1266 59 22" textPosition="2327 1266" /> <org.gk.render.RenderableComplex id="1114" reactomeId="8856287" position="3270 1506" bounds="3225 1488 90 36" textPosition="3227 1488" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="1178" reactomeId="8852332" position="2649 1370" bounds="2599 1357 100 27" textPosition="2603 1359"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.0" 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points="2493 493, 2453 491, 2404 489" position="2453 491" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="30" /> </Inputs> <Outputs> <Output id="23" points="2480 707" /> <Output id="24" points="2140 439" /> </Outputs> <Properties> <displayName>Dissociation of the COP1-p53 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="34" reactomeId="349444" points="1890 432, 1920 436, 1956 436" position="1920 436" lineWidth="1.0"> <Inputs> <Input id="17" points="1866 420" /> <Input id="28" points="1850 438" /> </Inputs> <Outputs> <Output id="14" points="2000 388" /> <Output id="24" points="2020 432" /> </Outputs> <Catalysts> <Catalyst id="578" points="1641 414, 1841 372" /> </Catalysts> <Properties> <displayName>Phosphorylation of COP1 at Ser-387 by ATM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="35" reactomeId="264444" points="3365 774, 3372 820, 3392 899" position="3372 820" lineWidth="1.0"> <Inputs> <Input id="25" points="3352 737" /> <Input id="27" stoichiometry="4" points="3311 782" /> </Inputs> <Outputs> <Output id="29" /> </Outputs> <Catalysts> <Catalyst id="25" points="3366 737, 3413 777" /> </Catalysts> <Properties> <displayName>Autoubiquitination of phospho-COP1(Ser-387 )</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="36" reactomeId="69600" points="1581 771, 1621 790, 1667 872" position="1621 790" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1973" /> </Inputs> <Outputs> <Output id="1635" stoichiometry="3" /> </Outputs> <Catalysts> <Catalyst id="1636" points="1602 830" /> </Catalysts> <Properties> <displayName>Proteolytic degradation of ubiquitinated-Cdc25A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="47" reactomeId="69598" points="1544 878, 1543 808, 1550 771" position="1543 808" lineWidth="1.0"> 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lineWidth="1.0"> <Inputs> <Input id="544" points="1789 260" /> <Input id="545" points="1807 302" /> </Inputs> <Outputs> <Output id="546" points="1901 304" /> <Output id="547" points="1248 301, 1323 360, 1840 359" /> <Output id="173" points="1945 266" /> </Outputs> <Catalysts> <Catalyst id="544" points="1789 221, 1831 215" /> </Catalysts> <Properties> <displayName>Phosphorylation and activation of CHEK2 by ATM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="191" reactomeId="75809" points="1241 1203, 1280 1259, 1247 1352" position="1280 1259" lineWidth="1.0"> <Inputs> <Input id="193" points="1231 1196" /> <Input id="1260" points="1212 1233" /> </Inputs> <Outputs> <Output id="194" points="1168 1478, 1237 1401" /> <Output id="195" points="1218 1342" /> </Outputs> <Catalysts> <Catalyst id="570" points="2547 296, 1320 1241" /> </Catalysts> <Properties> <displayName>Phosphorylation of Cdc25C at Ser216 by CHEK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="196" reactomeId="75016" points="479 812, 480 832, 480 868" position="480 832" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="543" points="424 818" /> <Input id="198" points="480 774" /> </Inputs> <Outputs> <Output id="199" /> </Outputs> <Properties> <displayName>Association of p-S216-CDC25C with 14-3-3 proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="209" reactomeId="75028" points="1099 703, 1077 756, 1062 788" position="1077 756" lineWidth="1.0"> <Inputs> <Input id="210" points="1049 721" /> <Input id="211" points="1082 683" /> </Inputs> <Outputs> <Output id="212" points="1044 824" /> <Output id="213" points="1033 784" /> </Outputs> <Catalysts> <Catalyst id="159" points="1138 1059" /> </Catalysts> <Properties> <displayName>Phosphorylation of Wee1 kinase by Chk1</displayName> </Properties> </org.gk.render.RenderableReaction> 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</Catalysts> <Properties> <displayName>Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="248" reactomeId="176175" points="734 1096, 736 1137, 743 1202" position="736 1137" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="249" points="736 990" /> <Input id="250" points="787 1057" /> </Inputs> <Outputs> <Output id="251" /> </Outputs> <Properties> <displayName>Stalling of DNA replication fork and RPA binding</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="252" reactomeId="176250" points="904 1113, 940 1118, 945 1181" position="940 1118" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="161" points="881 852" /> <Input id="251" points="810 1206, 826 1201" /> </Inputs> <Outputs> <Output id="253" /> </Outputs> <Properties> <displayName>Binding of ATR-ATRIP to the RPA-ssDNA complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="270" reactomeId="176101" points="753 1296, 754 1309, 755 1352" position="754 1309" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="251" points="747 1244" /> <Input id="271" points="796 1284" /> </Inputs> <Outputs> <Output id="272" /> </Outputs> <Properties> <displayName>Recruitment of Rad17-RFC complex to DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="273" reactomeId="176264" points="791 1451, 756 1451, 755 1497" position="756 1451" lineWidth="1.0"> <Inputs> <Input id="274" points="815 1451" /> <Input id="272" points="768 1408" /> </Inputs> <Outputs> <Output id="275" /> </Outputs> <Catalysts> <Catalyst id="272" points="756 1408" /> </Catalysts> <Properties> <displayName>Recruitment of the Rad9-Hus1-Rad1 complex to DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="284" reactomeId="176318" points="750 508, 754 538, 759 563" position="754 538" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="285" points="715 481" /> <Input id="286" points="780 494" /> </Inputs> <Outputs> <Output id="287" /> </Outputs> <Properties> <displayName>Loading of claspin onto DNA during replication origin firing</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="288" reactomeId="176298" points="757 624, 758 673, 757 715" position="758 673" lineWidth="1.0"> <Inputs> <Input id="287" points="758 619" /> <Input id="289" stoichiometry="2" points="721 646" /> </Inputs> <Outputs> <Output id="290" points="752 776" /> <Output id="291" stoichiometry="2" points="724 723" /> </Outputs> <Catalysts> <Catalyst id="161" points="872 824" /> </Catalysts> <Properties> <displayName>Activation of claspin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="300" reactomeId="69604" points="1378 704, 1427 714, 1455 740" position="1427 714" lineWidth="1.0"> <Inputs> <Input id="60" points="1268 456" /> <Input id="1654" stoichiometry="5" points="1382 588" /> </Inputs> <Outputs> <Output id="61" points="1527 697" /> <Output id="1657" stoichiometry="5" points="1421 638" /> </Outputs> <Catalysts> <Catalyst id="159" points="1164 1059, 1352 879" /> </Catalysts> <Properties> <displayName>Phosphorylation of CDC25A by CHEK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="327" reactomeId="75010" points="1158 1228, 1144 1275, 1162 1413" position="1144 1275" lineWidth="1.0"> <Inputs> <Input id="193" points="1176 1202" /> <Input id="1260" points="1178 1240" /> </Inputs> <Outputs> <Output id="194" points="1154 1478" /> <Output id="195" points="1187 1354" /> </Outputs> <Catalysts> <Catalyst id="159" points="1138 1107, 1107 1240" /> </Catalysts> <Properties> <displayName>Phosphorylation of Cdc25C at Ser 216 by Chk1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="379" reactomeId="141409" points="436 328, 458 342, 458 382" position="458 342" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1327" points="504 291" /> <Input id="380" points="414 314" /> </Inputs> <Outputs> <Output id="382" /> </Outputs> <Properties> <displayName>Mad1 binds kinetochore</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="383" reactomeId="141431" points="459 444, 459 467, 459 506" position="459 467" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="382" points="459 424" /> <Input id="384" points="507 445" /> </Inputs> <Outputs> <Output id="385" /> </Outputs> <Properties> <displayName>MAD2 associates with the Mad1 kinetochore complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="386" reactomeId="141422" points="459 548, 459 578, 459 618" position="459 578" lineWidth="1.0"> <Inputs> <Input id="385" /> </Inputs> <Outputs> <Output id="387" /> </Outputs> <Properties> <displayName>MAD2 converted to an inhibitory state via interaction with Mad1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="396" reactomeId="141439" points="393 636, 373 636, 373 402" position="373 636" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="387" /> </Inputs> <Outputs> <Output id="397" points="271 402" /> <Output id="382" points="395 402" /> </Outputs> <Properties> <displayName>Release of activated MAD2 from kinetochores</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="406" reactomeId="141429" points="230 354, 254 354, 293 355" position="254 354" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="397" points="231 384" /> <Input id="407" points="230 327" /> </Inputs> <Outputs> <Output id="408" /> </Outputs> <Properties> <displayName>Inactivation of APC/C via CDC20 sequestration</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="425" reactomeId="141437" points="160 312, 161 275, 161 240" position="161 275" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="397" points="194 401, 161 400" /> <Input id="407" points="197 312" /> <Input id="426" points="143 308" /> <Input id="427" points="199 285" /> </Inputs> <Outputs> <Output id="428" /> </Outputs> <Properties> <displayName>Formation of the MCC complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="437" reactomeId="141423" points="160 154, 160 137, 160 112" position="160 137" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="428" points="160 184" /> <Input id="438" points="212 149" /> </Inputs> <Outputs> <Output id="439" /> </Outputs> <Properties> <displayName>Binding of the MCC complex to the APC/C complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="446" reactomeId="349455" points="1772 1085, 1726 1091, 1703 1087" position="1726 1091" lineWidth="1.0"> <Inputs> <Input id="591" points="1807 1094" /> <Input id="592" points="1801 1058" /> </Inputs> <Outputs> <Output id="593" points="1663 1079" /> <Output id="594" points="1651 1112" /> </Outputs> <Catalysts> <Catalyst id="578" points="1576 451, 1692 830" /> </Catalysts> <Properties> <displayName>Phosphorylation of MDM4 by ATM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="516" reactomeId="69608" points="1354 502, 1401 502, 1434 504" position="1401 502" lineWidth="1.0"> <Inputs> <Input id="1654" stoichiometry="3" points="1377 557" /> <Input id="60" points="1280 456" /> </Inputs> <Outputs> <Output id="1657" stoichiometry="3" points="1419 607" /> <Output id="1658" points="1479 520" /> </Outputs> <Catalysts> <Catalyst id="570" points="2540 296, 2236 474, 1474 478" /> </Catalysts> <Properties> <displayName>Phosphorylation of CDC25A by CHEK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="522" points="2813 1071, 2758 1093" position="2785 1082" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="11" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="552" reactomeId="5683735" points="1381 260, 1382 259, 1423 257" position="1382 259" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="547" points="1347 258" /> <Input id="172" points="1381 318" /> </Inputs> <Outputs> <Output id="544" /> </Outputs> <Properties> <displayName>CHEK2 is recruited to DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="565" reactomeId="5683774" points="2050 267, 2110 269, 2154 268" position="2110 269" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="173" stoichiometry="2" /> </Inputs> <Outputs> <Output id="566" /> </Outputs> <Properties> <displayName>p-T68-CHEK2 dimerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="567" reactomeId="5683792" points="2332 267, 2378 265, 2410 265" position="2378 265" lineWidth="1.0"> <Inputs> <Input id="566" points="2300 267" /> <Input id="568" stoichiometry="3" points="2312 307" /> </Inputs> <Outputs> <Output id="569" stoichiometry="3" points="2442 291" /> <Output id="570" stoichiometry="2" points="2506 271" /> </Outputs> <Catalysts> <Catalyst id="566" points="2249 253, 2318 218" /> </Catalysts> <Properties> <displayName>p-T68-CHEK2 autophosphorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="576" interactionType="Activate" points="918 239, 1038 244" position="978 241" lineWidth="2.0"> <Inputs> <Input id="575" /> </Inputs> <Outputs> <Output id="547" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="579" interactionType="Activate" points="918 264, 1269 391, 1500 419" position="1269 391" lineWidth="2.0"> <Inputs> <Input id="575" /> </Inputs> <Outputs> <Output id="578" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="588" reactomeId="5693609" points="2180 836, 2241 837, 2304 829" position="2241 837" lineWidth="1.0"> <Inputs> <Input id="525" points="2145 830" /> <Input id="1222" stoichiometry="4" points="2149 867" /> </Inputs> <Outputs> <Output id="23" points="2452 751" /> <Output id="1220" stoichiometry="4" points="2324 862" /> </Outputs> <Catalysts> <Catalyst id="578" points="1633 451, 2189 623" /> </Catalysts> <Properties> <displayName>ATM phosphorylates TP53 at S15</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="626" reactomeId="69685" points="2550 839, 2549 869, 2544 905" position="2549 869" lineWidth="1.0"> <Inputs> <Input id="23" points="2501 751, 2535 794" /> <Input id="627" stoichiometry="4" points="2496 819" /> </Inputs> <Outputs> <Output id="628" stoichiometry="4" points="2488 940" /> <Output id="629" points="2457 1011, 2541 982" /> </Outputs> <Catalysts> <Catalyst id="570" points="2570 296, 2597 833" /> </Catalysts> <Properties> <displayName>CHEK2 phosphorylates TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="630" reactomeId="6803719" points="2414 1077, 2437 1083, 2521 1072" position="2437 1083" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="629" points="2411 1053" /> <Input id="631" points="2362 1110" /> </Inputs> <Outputs> <Output id="632" /> </Outputs> <Properties> <displayName>TP53 binds ZNF385A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="633" reactomeId="6803801" points="2678 966, 2717 969, 2760 970" position="2717 969" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="632" points="2600 1045" /> <Input id="539" points="2647 897" /> </Inputs> <Outputs> <Output id="634" /> </Outputs> <Properties> <displayName>TP53 in complex with ZNF385A binds the CDKN1A promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="666" reactomeId="6803388" points="2647 897, 2737 901, 3065 932" position="2737 901" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="539" /> </Inputs> <Outputs> <Output id="667" /> </Outputs> <Activators> <Activator id="634" points="2794 945" /> </Activators> <Properties> <displayName>TP53 stimulates CDKN1A (p21) transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="669" reactomeId="6803411" points="3102 958, 3077 1040, 2883 1056" position="3077 1040" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="667" /> </Inputs> <Outputs> <Output id="11" /> </Outputs> <Inhibitors> <Inhibitor id="670" points="3133 1071" /> </Inhibitors> <Properties> <displayName>PCBP4 modulates CDKN1A translation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="671" reactomeId="6803403" points="3134 999, 3140 1030, 3156 1071" position="3140 1030" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="667" points="3120 958" /> <Input id="672" points="3179 965" /> </Inputs> <Outputs> <Output id="670" /> </Outputs> <Properties> <displayName>PCBP4 binds the CDKN1A mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="735" reactomeId="187934" points="2796 1144, 2829 1179, 2837 1244" position="2829 1179" lineWidth="1.0"> <Inputs> <Input id="5" points="2750 1130" /> <Input id="736" points="2778 1167" /> </Inputs> <Outputs> <Output id="737" /> </Outputs> <Catalysts> <Catalyst id="5" points="2758 1113, 2826 1124" /> </Catalysts> <Properties> <displayName>Inactivation of Cyclin A:Cdk2 complexes by p27/p21</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="800" reactomeId="6799332" points="2179 740, 2246 739, 2314 726" position="2246 739" lineWidth="1.0"> <Inputs> <Input id="525" points="2102 809" /> <Input id="589" stoichiometry="4" points="2154 733" /> </Inputs> <Outputs> <Output id="23" points="2442 728" /> <Output id="590" stoichiometry="4" points="2345 756" /> </Outputs> <Catalysts> <Catalyst id="803" points="2277 706" /> </Catalysts> <Properties> <displayName>ATR phosphorylates TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="804" reactomeId="6799246" points="2388 828, 2389 884, 2400 947" position="2389 884" lineWidth="1.0"> <Inputs> <Input id="23" points="2466 751, 2420 792" /> <Input id="627" stoichiometry="4" points="2450 816" /> </Inputs> <Outputs> <Output id="629" points="2407 1011" /> <Output id="628" stoichiometry="4" points="2449 952" /> </Outputs> <Catalysts> <Catalyst id="159" points="1189 1107, 1373 1186, 1681 954, 2282 932" /> </Catalysts> <Properties> <displayName>CHEK1 phosphorylates TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="838" reactomeId="6804955" points="1779 707, 1780 684, 1788 657" position="1780 684" lineWidth="1.0"> <Inputs> <Input id="839" points="1778 739" /> <Input id="840" stoichiometry="4" points="1722 721" /> </Inputs> <Outputs> <Output id="841" stoichiometry="4" points="1843 632" /> <Output id="842" points="1778 612" /> </Outputs> <Catalysts> <Catalyst id="578" points="1581 451, 1679 619" /> </Catalysts> <Properties> <displayName>ATM phosphorylates MDM2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="874" reactomeId="349426" points="1598 1200, 1600 1221, 1597 1250" position="1600 1221" lineWidth="1.0"> <Inputs> <Input id="594" points="1597 1164" /> <Input id="875" stoichiometry="2" points="1657 1184" /> </Inputs> <Outputs> <Output id="876" stoichiometry="2" points="1684 1239" /> <Output id="877" points="1600 1281" /> </Outputs> <Catalysts> <Catalyst id="570" points="2548 296, 1454 1176" /> </Catalysts> <Properties> <displayName>Phosphorylation of MDM4 by CHEK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="942" reactomeId="6804741" points="1990 950, 2010 960, 2017 996" position="2010 960" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="943" points="1908 963" /> <Input id="839" stoichiometry="2" points="1798 781" /> </Inputs> <Outputs> <Output id="945" /> </Outputs> <Inhibitors> <Inhibitor id="578" points="1615 451, 1943 593" /> </Inhibitors> <Properties> <displayName>MDM2 forms homo- or heterodimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="944" points="1784 781, 1847 947" position="1815 864" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="839" /> </Inputs> <Outputs> <Output id="943" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="946" points="1901 1085, 1960 1064" position="1930 1074" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="591" /> </Inputs> <Outputs> <Output id="945" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1043" reactomeId="6804724" points="1600 1362, 1597 1382, 1600 1412" position="1597 1382" lineWidth="1.0"> <Inputs> <Input id="1044" stoichiometry="6" points="1509 1348" /> <Input id="877" points="1601 1337" /> </Inputs> <Outputs> <Output id="1045" /> </Outputs> <Catalysts> <Catalyst id="877" points="1623 1337, 1663 1382" /> </Catalysts> <Properties> <displayName>MDM2 ubiquitinates phosphorylated MDM4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1077" reactomeId="5633460" points="2140 1060, 2202 1112, 2196 1246" position="2202 1112" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="945" points="2097 1047" /> <Input id="525" points="2093 837" /> </Inputs> <Outputs> <Output id="1078" /> </Outputs> <Inhibitors> <Inhibitor id="1201" points="2124 1113" /> </Inhibitors> <Properties> <displayName>MDM2 binds TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1113" reactomeId="6793685" points="2703 1490, 2778 1499, 3222 1505" position="2778 1499" lineWidth="1.0"> <Inputs> <Input id="1080" /> </Inputs> <Outputs> <Output id="1114" /> </Outputs> <Properties> <displayName>Ubiquitinated TP53 translocates to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1177" reactomeId="8852337" points="2696 1418, 2714 1415, 2732 1413" position="2714 1415" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1080" points="2666 1464" /> <Input id="1178" points="2662 1387" /> </Inputs> <Outputs> <Output id="1179" /> </Outputs> <Properties> <displayName>GTSE1 binds TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1180" reactomeId="8852351" points="2836 1396, 3118 1311, 3196 1268" position="3118 1311" lineWidth="1.0"> <Inputs> <Input id="1179" /> </Inputs> <Outputs> <Output id="1181" /> </Outputs> <Properties> <displayName>GTSE1 promotes translocation of TP53 to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1182" reactomeId="8852354" points="3291 1256, 3322 1267, 3345 1301" position="3322 1267" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1181" /> </Inputs> <Outputs> <Output id="1185" points="3323 1325" /> <Output id="1326" points="3383 1307" /> </Outputs> <Catalysts> <Catalyst id="26" points="3395 1081" /> </Catalysts> <Properties> <displayName>GTSE1 facilitates proteasome-mediated degradation of TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1194" reactomeId="6804879" points="2335 1386, 2329 1403, 2335 1442" position="2329 1403" lineWidth="1.0"> <Inputs> <Input id="1078" points="2250 1323" /> <Input id="1081" stoichiometry="12" points="2338 1294" /> </Inputs> <Outputs> <Output id="945" points="2025 1064, 2066 1495" /> <Output id="1080" points="2607 1478" /> </Outputs> <Catalysts> <Catalyst id="1078" points="2200 1329, 2216 1423" /> </Catalysts> <Inhibitors> <Inhibitor id="1202" points="2400 1384" /> </Inhibitors> <Properties> <displayName>MDM2 ubiquitinates TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1523" reactomeId="9029987" points="1150 1478, 1123 1289, 851 974, 511 774" position="851 974" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="194" /> </Inputs> <Outputs> <Output id="198" /> </Outputs> <Properties> <displayName>p-S216-CDC25C translocates to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1680" reactomeId="9942578" points="1270 512, 1285 552, 1294 603" position="1285 552" lineWidth="1.0"> <Inputs> <Input id="60" points="1264 456" /> <Input id="1681" stoichiometry="2" points="1215 464" /> </Inputs> <Outputs> <Output id="1682" stoichiometry="2" points="1236 599" /> <Output id="1683" points="1275 648" /> </Outputs> <Catalysts> <Catalyst id="1684" points="1238 546" /> </Catalysts> <Properties> <displayName>Phosphorylation of CDC25A by p38 MAPK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1752" reactomeId="9943662" points="1211 847, 1244 817, 1264 801" position="1244 817" lineWidth="1.0"> <Inputs> <Input id="1753" points="1188 862" /> <Input id="1754" points="1187 831" /> </Inputs> <Outputs> <Output id="1755" points="1250 771" /> <Output id="1756" points="1293 837" /> </Outputs> <Catalysts> <Catalyst id="159" points="1150 1059" /> </Catalysts> <Properties> <displayName>CHEK1 phosphorylates NEK11</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1797" reactomeId="9943678" points="1530 585, 1539 604, 1550 633" position="1539 604" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1654" stoichiometry="2" points="1405 573" /> <Input id="1658" points="1527 563" /> </Inputs> <Outputs> <Output id="61" points="1553 653" /> <Output id="1657" stoichiometry="2" points="1440 623" /> </Outputs> <Catalysts> <Catalyst id="159" points="1165 1059, 1378 867, 1486 605" /> </Catalysts> <Properties> <displayName>CHEK1 phosphorylates CHEK2-phosphorylated CDC25A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1841" reactomeId="9943687" points="1171 420, 1125 420, 1078 420" position="1125 420" lineWidth="1.0"> <Inputs> <Input id="60" points="1226 433" /> <Input id="1842" points="1178 400" /> </Inputs> <Outputs> <Output id="1843" points="1098 457" /> <Output id="1844" points="1046 397" /> </Outputs> <Catalysts> <Catalyst id="1845" points="1104 370" /> </Catalysts> <Properties> <displayName>PLK3 phosphorylates CDC25A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1855" reactomeId="9943675" points="1103 538, 1106 574, 1153 651" position="1106 574" lineWidth="1.0"> <Inputs> <Input id="1843" points="1104 491" /> <Input id="1681" points="1191 464" /> </Inputs> <Outputs> <Output id="1858" points="1193 695" /> <Output id="1682" points="1198 615" /> </Outputs> <Catalysts> <Catalyst id="1859" points="1061 568" /> </Catalysts> <Properties> <displayName>GSK3B phosphorylates CDC25A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1887" reactomeId="9943676" points="1355 954, 1355 982, 1348 1020" position="1355 982" lineWidth="1.0"> <Inputs> <Input id="1888" points="1382 937" /> <Input id="1892" stoichiometry="3" points="1385 969" /> </Inputs> <Outputs> <Output id="1893" points="1314 1079" /> <Output id="1894" stoichiometry="3" points="1381 1029" /> </Outputs> <Catalysts> <Catalyst id="1756" points="1303 868, 1304 986" /> </Catalysts> <Properties> <displayName>NEK11 phosphorylates CDC25A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1889" points="1532 697, 1430 774, 1400 899" position="1430 774" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="61" /> </Inputs> <Outputs> <Output id="1888" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1890" points="1276 720, 1289 723, 1390 899" position="1289 723" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1858" /> </Inputs> <Outputs> <Output id="1888" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1891" points="1276 679, 1391 899" position="1333 789" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1683" /> </Inputs> <Outputs> <Output id="1888" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1962" reactomeId="9943736" points="1458 959, 1455 997, 1469 1035" position="1455 997" lineWidth="1.0"> <Inputs> <Input id="1888" points="1417 937" /> <Input id="1892" stoichiometry="2" points="1428 971" /> </Inputs> <Outputs> <Output id="1965" points="1431 1059" /> <Output id="1894" stoichiometry="2" points="1423 1034" /> </Outputs> <Catalysts> <Catalyst id="1966" points="1487 990" /> </Catalysts> <Properties> <displayName>Casein kinase I phosphorylates CDC25A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1968" points="1447 1059, 1582 1000, 1630 926, 1582 920" position="1606 963" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1965" /> </Inputs> <Outputs> <Output id="1967" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1969" points="1328 1138, 1374 1171, 1610 991, 1639 920, 1582 917" position="1610 991" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1893" /> </Inputs> <Outputs> <Output id="1967" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of Cell Cycle Checkpoints (451785)
