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Details on Person Tpl2 (also known as Cot, officially known as MAP3K8) is cons...
| Class:Id | Summation:451640 |
|---|---|
| _displayName | Tpl2 (also known as Cot, officially known as MAP3K8) is cons... |
| _timestamp | 2017-12-08 16:49:56 |
| created | [InstanceEdit:451629] Jupe, S, 2010-01-07 |
| literatureReference | [LiteratureReference:451639] Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages [LiteratureReference:208207] Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues |
| modified | [InstanceEdit:451663] Jupe, S, 2010-01-08 [InstanceEdit:507731] Jupe, S, 2010-02-08 [InstanceEdit:9032268] Orlic-Milacic, Marija, 2017-12-08 |
| text | Tpl2 (also known as Cot, officially known as MAP3K8) is constitutively bound to NFKB p105 (p105) which inhibits its MEK kinase activity in resting cells. Proteolysis of p105 frees Tpl2 from p105 and allows subsequent phosphorylation and activation of MEK1. Tpl2 can also activate SEK1 (MAP2K4). Phosphorylation of Tpl-2 is believed to play a role in its activation (Cho et al, 2005; Robinson et al. 2007). Positions of phosphorylations represented here are inferred from general experimental data (Zheng & Guan, 1994). |
| (summation) | [Reaction:451649] TPL2 phosphorylates MEK1, SEK1 [Homo sapiens] [Reaction:451681] Tpl2 phosphorylates Mek1, Sek1 [Mus musculus] |
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No pathways have been reviewed or authored by Tpl2 (also known as Cot, officially known as MAP3K8) is cons... (451640)
