Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person NFKB p105, TPL2 (COT) and ABIN2 form a stable complex

Class:Id	Reaction:451634
_displayName	NFKB p105, TPL2 (COT) and ABIN2 form a stable complex
_doRelease	TRUE
_timestamp	2015-08-25 07:49:43
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:451629] Jupe, S, 2010-01-07
edited	[InstanceEdit:744683] Jupe, S, 2010-05-17
input	[EntityWithAccessionedSequence:451607] NFKB1(1-968) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:451661] TNIP2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:389388] MAP3K8 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:451646] TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105 [LiteratureReference:451627] NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity [LiteratureReference:451637] ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability
modified	[InstanceEdit:451663] Jupe, S, 2010-01-08 [InstanceEdit:744684] Jupe, S, 2010-05-17 [InstanceEdit:5687879] Shamovsky, Veronica, 2015-04-10 [InstanceEdit:6791484] Shamovsky, Veronica, 2015-08-20 [InstanceEdit:6792550] Shamovsky, Veronica, 2015-08-25 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NFKB p105, TPL2 (COT) and ABIN2 form a stable complex
output	[Complex:451638] NFKB1:MAP3K8:TNIP2 [cytosol] [Homo sapiens]
regulatedBy	[NegativeRegulation:451645] Negative regulation by '3xUb-p-S927,S932-NFKB1(1-968) [cytosol]' [NegativeRegulation:5692833] Negative regulation by '3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]'
releaseDate	2010-06-15
reviewed	[InstanceEdit:744680] Pinteaux, E, 2010-05-17 [InstanceEdit:6791477] DeCicco-Skinner, Kathleen L., 2015-08-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105095] R-HSA-451634.5
summation	[Summation:451631] The C-terminal half of NFKB1 p105 forms a high-affinity stoi... [Summation:451628] Degradation of NFKB p105 frees Tpl2 from p105 allowing it to...
(hasEvent)	[Pathway:5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation [Homo sapiens]
(precedingEvent)	[Reaction:5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776066] Update Tracker - [Reaction:451634] NFKB p105, TPL2 (COT) and ABIN2 form a stable complex - v78:[addSummation] [_UpdateTracker:9784681] Update Tracker - [Reaction:451634] NFKB p105, TPL2 (COT) and ABIN2 form a stable complex - v53:[addRegulator, modifyText] [_UpdateTracker:9786018] Update Tracker - [Reaction:451634] NFKB p105, TPL2 (COT) and ABIN2 form a stable complex - v50:[add_removeRegulator] [_UpdateTracker:9789065] Update Tracker - [Reaction:451634] NFKB p105, TPL2 (COT) and ABIN2 form a stable complex - v39:[modifyText] [_UpdateTracker:9789647] Update Tracker - [Reaction:451634] NFKB p105, TPL2 (COT) and ABIN2 form a stable complex - v37:[modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (451634)