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Details on Person The C-terminal half of NFKB1 p105 forms a high-affinity stoi...
| Class:Id | Summation:451631 |
|---|---|
| _displayName | The C-terminal half of NFKB1 p105 forms a high-affinity stoi... |
| _timestamp | 2015-04-10 14:19:43 |
| created | [InstanceEdit:451629] Jupe, S, 2010-01-07 |
| literatureReference | [LiteratureReference:451637] ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability [LiteratureReference:451635] NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase [LiteratureReference:451632] Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide |
| modified | [InstanceEdit:451663] Jupe, S, 2010-01-08 [InstanceEdit:507731] Jupe, S, 2010-02-08 [InstanceEdit:561123] Jupe, S, 2010-03-25 [InstanceEdit:1604559] D'Eustachio, P, 2011-09-17 [InstanceEdit:5687879] Shamovsky, Veronica, 2015-04-10 |
| text | The C-terminal half of NFKB1 p105 forms a high-affinity stoichiometric association with MAP3K8 (TPL2) via two distinct interactions (Belich et al. 1999; Beinke et al. 2003). The Tpl2 C-terminus (residues 398-467) binds to a region N-terminal to the p105 ankyrin repeat region (human p105 residues 497-534), whereas the Tpl2 kinase domain interacts with the p105 death domain (Beinke et al. 2003). In unstimulated macrophages, all detectable Tpl2 is associated with p105 (Belich et al. 1999; Lang et al. 2004). Binding to p105 maintains the stability of Tpl2 but inhibits Tpl2 MEK kinase activity by preventing access to MEK (Beinke et al. 2003; Waterfield et al. 2003). Tpl2 phosphorylation at Thr-290 may also play a role in the activation of Tpl2 (Cho & Tsichlis 2005). A20-binding inhibitor of NFkappaB2 (ABIN-2 ot TNIP2) interacts with Tpl2 and p105 but preferentially forms a ternary complex with both proteins. As ABIN2 is a polyubiquitin binding protein, it has been suggested that it may facilitate recruitment of the p105/Tpl2 complex to the activated IKK complex, allowing IKK2 induced p105 phosphorylation and consequent Tpl2 activation. |
| (summation) | [Reaction:451634] NFKB p105, TPL2 (COT) and ABIN2 form a stable complex [Homo sapiens] |
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