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Details on Person NF-kappa-B essential modulator (NEMO, also known as IKKG abb...
| Class:Id | Summation:451573 |
|---|---|
| _displayName | NF-kappa-B essential modulator (NEMO, also known as IKKG abb... |
| _timestamp | 2010-10-04 07:56:00 |
| created | [InstanceEdit:451558] Jupe, S, 2010-01-05 |
| literatureReference | [LiteratureReference:451412] The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling [LiteratureReference:451562] Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO [LiteratureReference:451569] Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected] |
| modified | [InstanceEdit:451601] Jupe, S, 2010-01-06 [InstanceEdit:975771] Shamovsky, V, 2010-10-04 |
| text | NF-kappa-B essential modulator (NEMO, also known as IKKG abbreviated from Inhibitor of nuclear factor kappa-B kinase subunit gamma) is the regulatory subunit of the IKK complex which phosphorylates inhibitors of NF-kappa-B leading to dissociation of the inhibitor/NF-kappa-B complex. NEMO binds to K63-pUb chains (Ea et al. 2006; Wu et al. 2006), linking K63-pUb-hp-IRAK1 with the IKK complex. Models of IL-1R dependent activation of NF-kappaB suggest that the polyubiquitination of both TRAF6 and IRAK1 within a TRAF6:IRAK1 complex and their subsequent interactions with the TAK1 complex and IKK complex respectively brings these complexes into proximity, facilitating the TAK1-catalyzed activation of IKK (Moynagh, 2008). |
| (summation) | [Reaction:451561] NEMO binds polyubiquitinated IRAK1 [Homo sapiens] [Reaction:937032] NEMO subunit of IKK complex binds to activated IRAK1 [Homo sapiens] [Reaction:975119] NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 [Homo sapiens] |
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No pathways have been reviewed or authored by NF-kappa-B essential modulator (NEMO, also known as IKKG abb... (451573)
