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Details on Person K63polyUb-hp-IRAK1 [cytosol]

Class:Id	EntityWithAccessionedSequence:451565
_displayName	K63polyUb-hp-IRAK1 [cytosol]
_timestamp	2013-02-07 20:02:11
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:451558] Jupe, S, 2010-01-05
endCoordinate	712
hasModifiedResidue	[ModifiedResidue:446707] O-phospho-L-threonine at 209 [ModifiedResidue:446697] O-phospho-L-serine at 376 [ModifiedResidue:446700] O-phospho-L-threonine at 387 [ModifiedResidue:446703] O-phospho-L-threonine at unknown position [ModifiedResidue:446705] O-phospho-L-serine at unknown position [ModifiedResidue:446705] O-phospho-L-serine at unknown position [GroupModifiedResidue:3080595] ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 134 [GroupModifiedResidue:3080597] ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 160
literatureReference	[LiteratureReference:450158] Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation
modified	[InstanceEdit:3080598] D'Eustachio, P, 2013-02-07
name	K63polyUb-hp-IRAK1
referenceEntity	[ReferenceGeneProduct:404288] UniProt:P51617 IRAK1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1111619] R-HSA-451565.1
startCoordinate	1
(hasComponent)	[Complex:451560] Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] [Homo sapiens] [Complex:937043] K63-linked polyUb p-IRAK1:TRAF6 [cytosol] [Homo sapiens] [Complex:8948061] K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol] [Homo sapiens]
(input)	[Reaction:451561] NEMO binds polyubiquitinated IRAK1 [Homo sapiens]
(output)	[BlackBoxEvent:8948066] K63polyUb-IRAK1 dissociates [Homo sapiens]
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No pathways have been reviewed or authored by K63polyUb-hp-IRAK1 [cytosol] (451565)