Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6

Class:Id	BlackBoxEvent:451470
_displayName	Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6
_doRelease	TRUE
_timestamp	2010-12-02 14:41:54
authored	[InstanceEdit:451590] Shamovsky, V, 2010-01-05
catalystActivity	[CatalystActivity:451446] ubiquitin-protein transferase activity of oligo TRAF6 : p-IRAK2 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:451437] Shamovsky, V, 2010-01-05
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
goBiologicalProcess	[GO_BiologicalProcess:436928] free ubiquitin chain polymerization
inferredFrom	[Polymerisation:936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains [Homo sapiens]
input	[DefinedSet:434147] Ubiquitin [cytosol] [Gallus gallus] [DefinedSet:434147] Ubiquitin [cytosol] [Gallus gallus] [DefinedSet:434147] Ubiquitin [cytosol] [Gallus gallus]
literatureReference	[LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK [LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains [LiteratureReference:444058] Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling [LiteratureReference:451472] TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway
modified	[InstanceEdit:451964] Shamovsky, V, 2010-01-14 [InstanceEdit:571302] Shamovsky, V, 2010-04-09 [InstanceEdit:977266] D'Eustachio, P, 2010-10-15 [InstanceEdit:977383] Shamovsky, V, 2010-10-18 [InstanceEdit:994004] Shamovsky, V, 2010-11-05 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1063714] Shamovsky, V, 2010-11-25 [InstanceEdit:1094365] Shamovsky, V, 2010-11-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6
output	[Polymer:451962] free K63_polyubiquitin chain [cytosol] [Gallus gallus]
precedingEvent	[BlackBoxEvent:451450] Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 [Gallus gallus] [Reaction:451466] TRAF6 binding to activated IRAK2 stimulates its oligomerization [Gallus gallus]
releaseDate	2010-12-14
requiredInputComponent	[Complex:433960] UBE2N : UBE2V complex [cytosol] [Gallus gallus]
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1105925] R-GGA-451470.2
summation	[Summation:446233] TRAF6 generates unanchored Lys63-linked polyubiquitin chains...
(hasEvent)	[Pathway:433822] NFkB and MAPK activation mediated by TRAF6 [Gallus gallus]
(precedingEvent)	[Reaction:451463] pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex [Gallus gallus]
[Change default viewing format]

No pathways have been reviewed or authored by Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 (451470)