Query author contributions in Reactome

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Details on Person Diagram of HIV Life Cycle

Class:Id	PathwayDiagram:451240
_displayName	Diagram of HIV Life Cycle
_timestamp	2023-02-04 17:44:04
created	[InstanceEdit:451239] Gillespie, ME, 2009-12-30
height	2789
modified	[InstanceEdit:1679954] Wu, G, 2011-10-20 [InstanceEdit:1869595] Rothfels, K, 2011-10-31 [InstanceEdit:1929419] Gillespie, ME, 2011-11-02 [InstanceEdit:1946653] Gillespie, ME, 2011-11-03 [InstanceEdit:2453749] Gillespie, ME, 2012-08-15 [InstanceEdit:3004608] Gillespie, ME, 2013-01-29 [InstanceEdit:3072751] Gillespie, ME, 2013-02-06 [InstanceEdit:3076315] Gillespie, ME, 2013-02-06 [InstanceEdit:3076316] Gillespie, ME, 2013-02-06 [InstanceEdit:3076321] Gillespie, ME, 2013-02-06 [InstanceEdit:3076323] Gillespie, ME, 2013-02-06 [InstanceEdit:3076326] Gillespie, ME, 2013-02-06 [InstanceEdit:3076327] Gillespie, ME, 2013-02-06 [InstanceEdit:3076331] Gillespie, ME, 2013-02-06 [InstanceEdit:3076334] Gillespie, ME, 2013-02-06 [InstanceEdit:3076338] Gillespie, ME, 2013-02-06 [InstanceEdit:3076341] Gillespie, ME, 2013-02-06 [InstanceEdit:3076342] Gillespie, ME, 2013-02-06 [InstanceEdit:3139032] Gillespie, ME, 2013-02-13 [InstanceEdit:3149428] Gillespie, ME, 2013-02-14 [InstanceEdit:3149450] Gillespie, ME, 2013-02-14 [InstanceEdit:3149461] Gillespie, ME, 2013-02-14 [InstanceEdit:3149473] Gillespie, ME, 2013-02-14 [InstanceEdit:3149557] Gillespie, ME, 2013-02-15 [InstanceEdit:3159228] Gillespie, ME, 2013-02-19 [InstanceEdit:3159233] Gillespie, ME, 2013-02-19 [InstanceEdit:3211407] Gillespie, ME, 2013-03-06 [InstanceEdit:3211804] Gillespie, ME, 2013-03-08 [InstanceEdit:3211854] Gillespie, ME, 2013-03-08 [InstanceEdit:3595189] Gillespie, ME, 2013-05-21 [InstanceEdit:3604388] Matthews, L, 2013-05-23 [InstanceEdit:3621682] Gillespie, ME, 2013-05-23 [InstanceEdit:3621683] Gillespie, ME, 2013-05-23 [InstanceEdit:3629333] Gillespie, ME, 2013-05-24 [InstanceEdit:5147983] Gillespie, ME, 2013-11-18 [InstanceEdit:5606987] Matthews, Lisa, 2014-07-08 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:8855622] D'Eustachio, Peter, 2016-02-04 [InstanceEdit:8864244] Jupe, Steve, 2016-03-14 [InstanceEdit:8866365] D'Eustachio, Peter, 2016-03-30 [InstanceEdit:8951689] Jupe, Steve, 2016-12-08 [InstanceEdit:8960002] Orlic-Milacic, Marija, 2017-02-01 [InstanceEdit:9607292] Gillespie, Marc E, 2018-05-01 [InstanceEdit:9608474] D'Eustachio, Peter, 2018-05-15 [InstanceEdit:9613504] Gillespie, Marc E, 2018-07-13 [InstanceEdit:9615441] Matthews, Lisa, 2018-08-06 [InstanceEdit:9616911] D'Eustachio, Peter, 2018-08-15 [InstanceEdit:9638000] D'Eustachio, Peter, 2019-02-22 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9690700] Jassal, Bijay, 2020-06-04 [InstanceEdit:9693553] Jassal, Bijay, 2020-07-02 [InstanceEdit:9693558] Jassal, Bijay, 2020-07-02 [InstanceEdit:9696614] Jassal, Bijay, 2020-07-23 [InstanceEdit:9697047] Jassal, Bijay, 2020-08-05 [InstanceEdit:9697052] Jassal, Bijay, 2020-08-05 [InstanceEdit:9699031] Matthews, Lisa, 2020-09-09 [InstanceEdit:9724275] Stephan, Ralf, 2021-03-23 [InstanceEdit:9731578] Stephan, Ralf, 2021-05-21 [InstanceEdit:9757638] D'Eustachio, Peter, 2021-11-03 [InstanceEdit:9757642] D'Eustachio, Peter, 2021-11-03 [InstanceEdit:9767902] Matthews, Lisa, 2022-03-02 [InstanceEdit:9827780] May, Bruce, 2023-02-04
representedPathway	[Pathway:162587] HIV Life Cycle [Homo sapiens]
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0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 closed pre-initiation complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="66" reactomeId="167137" position="2010 1855" bounds="1951 1837 118 36" textPosition="1955 1838" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 open pre-initiation complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="67" reactomeId="113582" position="2034 1901" bounds="2012 1886 44 30" textPosition="2018 1890" /> <org.gk.render.RenderableComplex id="68" reactomeId="109634" position="1910 1968" bounds="1876 1957 68 22" textPosition="1891 1958" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableChemical id="69" reactomeId="113550" position="1987 1934" bounds="1974 1919 26 30" textPosition="1978 1923"> <Properties> <displayName>Pi</displayName> 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position="2427 1977" bounds="2403 1966 48 22" textPosition="2404 1966" /> <org.gk.render.RenderableComplex id="74" reactomeId="71307" position="2184 2138" bounds="2119 2113 130 50" textPosition="2122 2114" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="75" reactomeId="109626" position="2575 2194" bounds="2550 2183 51 22" textPosition="2557 2184" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="76" reactomeId="109629" position="2428 2068" bounds="2410 2057 36 22" textPosition="2410 2058" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TFIIA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="77" reactomeId="167094" position="2496 2020" bounds="2436 2002 120 36" textPosition="2443 2003" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 promoter:TFIID complex</displayName> </Properties> 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complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="81" reactomeId="167106" position="2425 1896" bounds="2365 1864 120 64" textPosition="2372 1865" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 initiation complex with phosphodiester-PPi intermediate</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="82" reactomeId="113541" position="3005 1853" bounds="2988 1838 35 30" textPosition="2993 1842" /> <org.gk.render.RenderableComplex id="84" reactomeId="167100" position="2535 1667" bounds="2470 1635 130 64" textPosition="2473 1636" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 transcription complex containing 9 nucleotide long transcript</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="85" reactomeId="167124" position="2862 1617" bounds="2797 1585 130 64" textPosition="2800 1586" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 transcription complex containing 4 nucleotide long transcript</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="86" reactomeId="167119" position="3043 1725" bounds="2978 1693 130 64" textPosition="2981 1694" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 transcription complex containing 3 nucleotide long transcript</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="87" reactomeId="167132" position="2008 1672" bounds="1943 1640 130 64" textPosition="1946 1641" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 transcription complex containing 11 nucleotide long transcript</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="88" reactomeId="167120" position="1679 1672" bounds="1614 1647 130 50" textPosition="1617 1648" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 transcription complex containing transcript to +30</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="89" reactomeId="167102" position="1492 1673" bounds="1427 1641 130 64" textPosition="1430 1642" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 transcription complex containing extruded transcript to +30</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="90" reactomeId="167107" position="1266 1872" bounds="1211 1847 111 50" textPosition="1212 1848" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>RNA Pol II with phosphorylated CTD: CE complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="91" reactomeId="77060" position="1337 2048" bounds="1308 2033 58 31" textPosition="1315 2038"> <Properties> <displayName>RNMT</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="93" reactomeId="72081" position="1337 1795" bounds="1296 1783 82 25" textPosition="1312 1785"> <Properties> <displayName>RNGTT</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="94" reactomeId="167139" position="1265 2169" bounds="1214 2151 102 36" textPosition="1221 2152" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>CE:Pol II CTD:Spt5 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="95" reactomeId="167123" position="1261 1985" bounds="1196 1953 130 64" textPosition="1204 1954" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>RNA Pol II with phosphorylated CTD: CE complex with activated GT</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="96" reactomeId="167127" position="1261 1674" bounds="1199 1619 125 110" textPosition="1199 1638" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="97" reactomeId="167070" position="1705 1243" bounds="1640 1211 130 64" textPosition="1640 1212" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>RNA Pol II (hypophosphorylated) complex bound to DSIF protein</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="98" reactomeId="167080" position="1293 1222" bounds="1228 1190 130 64" textPosition="1230 1191" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="99" reactomeId="167078" position="1944 1245" bounds="1879 1227 130 36" textPosition="1884 1228" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>DSIF:NELF:early elongation complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="100" reactomeId="112420" position="1551 1276" bounds="1505 1265 92 22" textPosition="1508 1266" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>DSIF complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="101" reactomeId="112432" position="1765 1177" bounds="1714 1166 102 22" textPosition="1720 1167" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NELF complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="102" reactomeId="167086" position="1544 1169" bounds="1479 1137 130 64" textPosition="1479 1138" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>RNA Pol II (hypophosphorylated):capped pre-mRNA complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="103" reactomeId="113416" position="1381 1162" bounds="1335 1151 92 22" textPosition="1357 1151"> <Properties> <displayName>CTDP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="104" reactomeId="167184" position="3374 1191" bounds="3309 1159 130 64" textPosition="3314 1160" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 Tat-containing processive elongation complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="105" reactomeId="167185" position="3236 1023" bounds="3171 998 130 50" textPosition="3174 999" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>HIV-1 elongation complex containing Tat</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="106" reactomeId="167193" position="3561 1421" bounds="3496 1396 130 50" textPosition="3499 1397" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Tat-containing elongation complex prior to separation</displayName> </Properties> 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hideComponents="true"> <Properties> <displayName>Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="114" reactomeId="165542" position="2037 993" bounds="1993 982 89 22" textPosition="1994 982" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" isForDisease="true" /> <org.gk.render.RenderableRNA id="116" reactomeId="165533" position="2215 989" bounds="2158 970 115 38" textPosition="2174 978" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0"> <Properties> <displayName>HIV-1 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableComplex id="117" reactomeId="180873" position="1597 1032" bounds="1532 1007 130 50" textPosition="1531 1008" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Rev multimer-bound HIV-1 mRNA:CRM1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> 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textPosition="684 618"> <Properties> <displayName>NMT2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="305" reactomeId="76194" position="815 535" bounds="779 520 72 30" textPosition="788 524"> <Properties> <displayName>CoA-SH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="306" reactomeId="113595" position="546 566" bounds="514 554 64 24" textPosition="534 555"> <Properties> <displayName>Ub</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="308" reactomeId="184398" position="741 349" bounds="709 338 64 22" textPosition="713 339" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESCRT-I</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="310" reactomeId="184174" position="818 687" bounds="768 672 100 30" textPosition="787 676"> <Properties> 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bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>Golgi membrane</displayName> </Properties> <Components> <Component id="773" /> <Component id="776" /> <Component id="786" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="335" reactomeId="175182" position="932 1282" bounds="874 1264 116 36" textPosition="878 1264"> <Properties> <displayName>PR (Protease) (P04585) protein</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="336" reactomeId="3008840" position="507 2188" bounds="485 2177 44 22" textPosition="487 2177"> <Properties> <displayName>PSIP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="337" reactomeId="3004619" position="500 2235" bounds="474 2224 53 22" textPosition="474 2224"> <Properties> <displayName>HMGA1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="338" 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textPosition="2155 758"> <Properties> <displayName>Spliced Env mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableProtein id="580" reactomeId="189343" position="1959 700" bounds="1910 675 99 50" textPosition="1918 675"> <Properties> <displayName>Envelope glycoprotein gp160</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="771" reactomeId="189843" position="1958 588" bounds="1915 570 87 36" textPosition="1915 571" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Trimeric ENV precursor</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="773" reactomeId="3149446" position="1959 469" bounds="1916 451 87 36" textPosition="1916 452" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="776" reactomeId="189281" position="1965 382" bounds="1910 364 110 36" textPosition="1913 365" bgColor="204 255 255" 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id="1000" reactomeId="173256" position="1722 394" bounds="1673 376 98 36" textPosition="1678 376"> <Properties> <displayName>VIF (P69723) protein</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1001" reactomeId="173193" position="1650 354" bounds="1625 342 50 25" textPosition="1634 344"> <Properties> <displayName>VPR</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntity id="1006" reactomeId="173782" position="1485 444" bounds="1434 433 102 22" textPosition="1441 433"> <Properties> <displayName>tRNA-Lysine3</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableProtein id="1008" reactomeId="173123" position="1608 408" bounds="1567 397 83 22" textPosition="1592 397" /> <org.gk.render.RenderableComplex id="1027" reactomeId="109634" position="2564 974" bounds="2530 963 68 22" textPosition="2545 964" bgColor="204 255 255" hideComponents="true" /> 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22" textPosition="2793 2070" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="1270" reactomeId="65888" position="2680 2170" bounds="2656 2159 48 22" textPosition="2657 2159" /> <org.gk.render.RenderableComplex id="1272" reactomeId="109629" position="2678 2068" bounds="2657 2057 43 22" textPosition="2660 2058" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="1273" reactomeId="109634" position="1621 2353" bounds="1602 2342 39 22" textPosition="1603 2343" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TFIIH</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1275" reactomeId="109634" position="2651 2098" bounds="2632 2087 39 22" textPosition="2633 2088" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="1277" reactomeId="109633" position="1568 1924" bounds="1550 1913 36 22" textPosition="1550 1914" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="1279" reactomeId="109626" position="2783 2047" bounds="2758 2036 51 22" textPosition="2765 2037" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="1286" reactomeId="109626" position="1568 2366" bounds="1543 2355 51 22" textPosition="1550 2356" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="1288" reactomeId="109629" position="1650 2328" bounds="1629 2318 42 20" textPosition="1632 2317" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="1290" reactomeId="65888" position="1644 2223" bounds="1620 2212 48 22" textPosition="1621 2212" /> <org.gk.render.RenderableChemical id="1291" reactomeId="8866361" position="936 1459" bounds="906 1444 60 30" textPosition="916 1448"> <Properties> <displayName>dNTP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1292" reactomeId="157171" position="1386 1567" bounds="1324 1535 125 64" textPosition="1324 1536" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Pol II transcription complex containing extruded transcript to +30</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1494" reactomeId="9608475" position="703 2321" bounds="639 2283 128 76" textPosition="639 2296" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1523" reactomeId="2161522" position="1059 1450" bounds="989 1423 141 54" textPosition="1007 1435"> <Properties> <displayName>Abacavir ADME</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableChemicalDrug id="1542" reactomeId="2162091" position="979 1529" bounds="927 1507 105 44" textPosition="939 1511" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0"> <Properties> <displayName>carbovir triphosphate</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableComplex id="1548" reactomeId="9684421" position="726 112" bounds="668 94 117 36" textPosition="668 95" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>Protease:Protease inhibitors</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1551" reactomeId="9680894" position="702 1529" bounds="667 1518 71 22" textPosition="667 1519" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>RTC:NRTIs</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1572" reactomeId="9684426" position="725 24" bounds="667 13 116 22" textPosition="667 13" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>Protease inhibitors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1648" reactomeId="9681061" position="597 1452" bounds="565 1441 65 22" textPosition="576 1441" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>NRTIs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="1650" reactomeId="171279" position="311 245" bounds="287 234 49 23" textPosition="291 235"> <Properties> <displayName>CCR5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="1651" reactomeId="9724272" position="311 182" bounds="278 166 66 32" textPosition="280 165" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>CCR5 inhibitors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1652" reactomeId="9724280" position="445 242" bounds="413 218 65 49" textPosition="413 218" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>CCR5 inhibitors:CCR5</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1688" reactomeId="9731558" position="917 2563" bounds="891 2552 53 22" textPosition="896 2552" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDrug="true" isForDisease="true"> <Properties> <displayName>INSTIs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1689" reactomeId="9731560" position="1010 2723" bounds="943 2704 134 38" textPosition="944 2707" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDrug="true" isForDisease="true" hideComponents="true"> <Properties> <displayName>IN bound to sticky 3' ends in PIC:INSTIs</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1690" reactomeId="9757634" position="1825 1317" bounds="1793 1302 64 31" textPosition="1809 1307" /> <org.gk.render.RenderableChemical id="1692" reactomeId="9757634" position="1947 1564" bounds="1915 1549 64 31" textPosition="1931 1554"> <Properties> <displayName>NTP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1694" reactomeId="9757634" position="2386 1728" bounds="2354 1713 64 31" textPosition="2370 1718" /> <org.gk.render.RenderableChemical id="1697" reactomeId="9757634" position="2079 1794" bounds="2047 1779 64 31" textPosition="2063 1784" /> <org.gk.render.RenderableChemical id="1700" reactomeId="9757634" position="2815 1717" bounds="2783 1702 64 31" textPosition="2799 1707" /> <org.gk.render.RenderableChemical id="1703" reactomeId="9757634" position="3116 1620" bounds="3084 1605 64 31" textPosition="3100 1610" /> <org.gk.render.RenderableChemical id="1705" reactomeId="9757634" position="2811 1837" bounds="2779 1822 64 31" textPosition="2795 1827" /> <org.gk.render.RenderableChemical id="1707" reactomeId="9757634" position="3633 1309" bounds="3601 1294 64 31" textPosition="3617 1299" /> <org.gk.render.RenderableChemical id="1710" reactomeId="9757634" position="3428 1028" bounds="3396 1013 64 31" textPosition="3412 1018" /> <org.gk.render.RenderableChemical id="1713" reactomeId="29358" position="2160 1296" bounds="2136 1281 48 30" textPosition="2140 1285" /> <org.gk.render.RenderableChemical id="1714" reactomeId="113582" position="2291 1313" bounds="2267 1298 48 30" textPosition="2271 1302" /> <org.gk.render.RenderableChemical id="1718" reactomeId="29358" position="1908 1200" bounds="1884 1185 48 30" textPosition="1888 1189" /> <org.gk.render.RenderableChemical id="1719" reactomeId="113582" position="2235 1210" bounds="2211 1195 48 30" textPosition="2215 1199" /> <org.gk.render.RenderableChemical id="1720" reactomeId="29358" position="1440 1737" bounds="1416 1722 48 30" textPosition="1420 1726" /> <org.gk.render.RenderableChemical id="1721" reactomeId="113582" position="1335 1748" bounds="1311 1733 48 30" textPosition="1315 1737" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="204" reactomeId="173771" points="776 1184, 813 1184, 853 1183" position="813 1184" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Dissociation"> <Inputs> <Input id="11" /> </Inputs> <Outputs> <Output id="5" points="727 1316" /> <Output id="9" points="912 1193" /> <Output id="8" points="893 1169" /> <Output id="335" points="917 1261" /> </Outputs> <Properties> <displayName>Formation of RTC (Reverse Transcription Complex)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="205" reactomeId="164527" points="783 1384, 784 1407, 784 1436" position="784 1407" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="5" points="740 1360" /> <Input id="13" points="861 1353" /> </Inputs> <Outputs> <Output id="4" /> </Outputs> <Properties> <displayName>Annealing of 3'-end of unwound transfer RNA primer with genomic RNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="206" reactomeId="182876" points="944 2197, 944 2220, 810 2188" position="944 2220" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="3" /> </Inputs> <Outputs> <Output id="10" /> </Outputs> <Activators> <Activator id="12" points="1174 2228" /> <Activator id="6" points="1168 2336" /> </Activators> <Properties> <displayName>Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="207" reactomeId="164508" points="152 797, 118 808, 168 833" position="118 808" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="16" /> </Inputs> <Outputs> <Output id="18" /> </Outputs> <Properties> <displayName>N and C terminal heptad repeat helices of gp41 form six-helix bundle</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="208" reactomeId="164500" points="183 541, 128 562, 163 575" position="128 562" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="19" /> </Inputs> <Outputs> <Output id="14" /> </Outputs> <Properties> <displayName>Conformational changes in gp120 exposes gp41</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="209" reactomeId="164509" points="162 237, 162 271, 197 286" position="162 271" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="22" points="212 247" /> <Input id="17" points="170 173" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> <Properties> <displayName>Binding of gp120 of ENV oligomer to the host CD4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="210" reactomeId="164524" points="284 878, 322 891, 323 913" position="322 891" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Dissociation"> <Inputs> <Input id="18" /> </Inputs> <Outputs> <Output id="20" points="289 920" /> <Output id="24" points="367 1031" /> </Outputs> <Properties> <displayName>Fusion of viral membrane with host cell membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="211" reactomeId="164510" points="203 328, 163 350, 193 372" position="163 350" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> <Properties> <displayName>Conformational change in gp120 of Env oligomer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="212" reactomeId="164507" points="146 462, 145 486, 176 495" position="145 486" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="15" points="195 418" /> <Input id="25" points="170 459" /> </Inputs> <Outputs> <Output id="19" /> </Outputs> <Properties> <displayName>CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="213" reactomeId="164521" points="182 699, 134 728, 164 741" position="134 728" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="23" /> </Inputs> <Outputs> <Output id="16" /> </Outputs> <Properties> <displayName>Insertion of gp41 fusion peptide into the target membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="214" reactomeId="164515" points="172 620, 123 641, 164 655" position="123 641" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="14" /> </Inputs> <Outputs> <Output id="23" /> </Outputs> <Properties> <displayName>Fusogenic activation of gp41</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="215" reactomeId="173642" points="373 1073, 373 1099, 451 1098" position="373 1099" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Dissociation"> <Inputs> <Input id="24" /> </Inputs> <Outputs> <Output id="28" points="535 1098" /> <Output id="26" points="500 1138" /> <Output id="1236" points="510 1058" /> </Outputs> <Properties> <displayName>Disintegration of matrix layer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="216" reactomeId="173111" points="584 1157, 614 1157, 655 1158" position="614 1157" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Dissociation"> <Inputs> <Input id="26" /> </Inputs> <Outputs> <Output id="27" points="701 1131" /> <Output id="11" points="678 1167" /> </Outputs> <Properties> <displayName>Disassembly of viral capsid</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="217" reactomeId="164528" points="611 1742, 641 1743, 679 1743" position="641 1743" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="34" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> <Catalysts> <Catalyst id="34" points="611 1718, 642 1706" /> </Catalysts> <Properties> <displayName>RNase H-mediated cleavage of the template strand</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="218" reactomeId="182859" points="473 1599, 446 1599, 409 1600" position="446 1599" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="30" /> </Inputs> <Outputs> <Output id="31" /> </Outputs> <Catalysts> <Catalyst id="36" points="446 1557" /> </Catalysts> <Properties> <displayName>RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="219" reactomeId="182795" points="815 1740, 847 1739, 877 1740" position="847 1739" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="38" /> </Inputs> <Outputs> <Output id="32" /> </Outputs> <Catalysts> <Catalyst id="38" points="797 1723, 846 1709" /> </Catalysts> <Properties> <displayName>RNase H-mediated degradation of the template strand</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="220" reactomeId="164520" points="405 1747, 439 1747, 468 1745" position="439 1747" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="29" /> </Inputs> <Outputs> <Output id="34" /> </Outputs> <Catalysts> <Catalyst id="29" points="405 1727, 438 1717" /> </Catalysts> <Properties> <displayName>Minus strand DNA synthesis resumes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="221" reactomeId="164503" points="339 1630, 338 1671, 337 1712" position="338 1671" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="31" /> </Inputs> <Outputs> <Output id="29" /> </Outputs> <Properties> <displayName>First strand transfer mediated by Repeated (R) sequence</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="222" reactomeId="164504" points="859 1503, 860 1529, 860 1553" position="860 1529" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="1291" points="909 1477" /> <Input id="4" points="817 1481" /> </Inputs> <Outputs> <Output id="37" points="901 1569" /> <Output id="33" points="835 1566" /> </Outputs> <Catalysts> <Catalyst id="4" points="796 1481, 808 1498" /> </Catalysts> <Inhibitors> <Inhibitor id="1542" points="924 1529" /> <Inhibitor id="1551" points="741 1529" /> </Inhibitors> <Properties> <displayName>Synthesis of minus strand strong stop DNA (-sssDNA)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="223" reactomeId="164519" points="709 1594, 655 1595, 618 1596" position="655 1595" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="33" /> </Inputs> <Outputs> <Output id="30" /> </Outputs> <Catalysts> <Catalyst id="33" points="709 1576, 652 1559" /> </Catalysts> <Properties> <displayName>RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="224" reactomeId="164513" points="944 1764, 942 1800, 943 1826" position="942 1800" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="32" /> </Inputs> <Outputs> <Output id="39" /> </Outputs> <Catalysts> <Catalyst id="32" points="935 1764, 916 1800" /> </Catalysts> <Properties> <displayName>3' PPT-primed initiation of plus-strand DNA synthesis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="225" reactomeId="173769" points="943 1868, 943 1892, 943 1918" position="943 1892" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="39" /> </Inputs> <Outputs> <Output id="40" /> </Outputs> <Catalysts> <Catalyst id="39" points="932 1868, 914 1892" /> </Catalysts> <Properties> <displayName>RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="226" reactomeId="164512" points="943 1960, 943 1982, 945 2007" position="943 1982" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="40" /> </Inputs> <Outputs> <Output id="41" /> </Outputs> <Properties> <displayName>Second strand transfer by annealing complementary PBS sequences</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="227" reactomeId="164505" points="945 2067, 944 2101, 944 2127" position="944 2101" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="41" /> </Inputs> <Outputs> <Output id="3" /> </Outputs> <Catalysts> <Catalyst id="41" points="936 2067, 923 2101" /> </Catalysts> <Properties> <displayName>Synthesis of full-length duplex viral DNA with a discontinuous plus strand</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="228" reactomeId="173115" points="703 2362, 704 2380, 704 2404" position="704 2380" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="1494" /> </Inputs> <Outputs> <Output id="42" points="708 2460" /> <Output id="49" points="735 2412" /> <Output id="156" points="667 2410" /> </Outputs> <Properties> <displayName>Formation of Pre-Integration Complex (PIC)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="229" reactomeId="164514" points="759 2484, 788 2483, 834 2483" position="788 2483" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="42" /> </Inputs> <Outputs> <Output id="51" /> </Outputs> <Properties> <displayName>Integrase binds viral DNA ends</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="230" reactomeId="162590" points="1121 2479, 1626 2466, 2018 2454" position="1626 2466" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="47" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> <Activators> <Activator id="1237" points="1625 2497" /> </Activators> <Properties> <displayName>Import of PIC to the Host Nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="231" reactomeId="164522" points="949 2481, 980 2481, 1009 2481" position="980 2481" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="51" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> <Properties> <displayName>Terminal (3' end) cleavage of viral DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="232" reactomeId="175117" points="2124 2482, 2158 2505, 2219 2511" position="2158 2505" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="44" /> </Inputs> <Outputs> <Output id="50" points="2202 2557" /> <Output id="48" points="2252 2503" /> <Output id="338" stoichiometry="2" points="2358 2626" /> </Outputs> <Properties> <displayName>1-LTR circle formation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="233" reactomeId="164523" points="2172 2266, 2200 2263, 2236 2263" position="2200 2263" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="56" /> </Inputs> <Outputs> <Output id="55" /> </Outputs> <Catalysts> <Catalyst id="56" points="2172 2289, 2200 2298" /> </Catalysts> <Properties> <displayName>Transesterification to connect viral DNA 3' ends to host DNA 5' ends</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="234" reactomeId="175108" points="2013 2370, 2012 2339, 2012 2306" position="2012 2339" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="44" points="2065 2423" /> <Input id="53" points="1960 2402" /> </Inputs> <Outputs> <Output id="56" points="2045 2293" /> <Output id="132" points="1973 2288" /> </Outputs> <Properties> <displayName>Target DNA binding</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="235" reactomeId="164506" points="2381 2266, 2416 2267, 2450 2265" position="2416 2267" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="55" /> </Inputs> <Outputs> <Output id="54" points="2462 2207" /> <Output id="338" stoichiometry="2" points="2383 2626" /> </Outputs> <Properties> <displayName>Gap repair completes provirus integration</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="236" reactomeId="175174" points="1870 2582, 1909 2582, 1949 2581" position="1909 2582" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="60" points="1849 2583" /> <Input id="44" points="2045 2482" /> </Inputs> <Outputs> <Output id="61" points="1978 2589" /> <Output id="138" points="1999 2564" /> </Outputs> <Properties> <displayName>Association of Ku heterodimer with viral DNA ends</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="237" reactomeId="175177" points="1337 2566, 1337 2590, 1337 2616" position="1337 2590" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="58" points="1367 2556" /> <Input id="155" points="1320 2560" /> </Inputs> <Outputs> <Output id="57" /> </Outputs> <Properties> <displayName>Association of XRCC4:DNA ligase IV complex with viral DNA ends</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="238" reactomeId="175258" points="1406 2650, 1448 2650, 1496 2650" position="1448 2650" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="57" /> </Inputs> <Outputs> <Output id="59" points="1567 2675" /> <Output id="60" points="1760 2594" /> <Output id="338" stoichiometry="2" points="2319 2647" /> <Output id="58" points="1404 2556" /> </Outputs> <Catalysts> <Catalyst id="57" points="1406 2670, 1447 2684" /> </Catalysts> <Properties> <displayName>2-LTR formation due to circularization of viral DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="239" reactomeId="175250" points="2162 2445, 2483 2413, 2553 2416" position="2483 2413" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="44" /> </Inputs> <Outputs> <Output id="62" points="2712 2433" /> <Output id="838" points="2692 2499" /> <Output id="840" stoichiometry="2" points="2641 2337" /> </Outputs> <Properties> <displayName>Suicidal integration leading to smaller circles of viral DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="240" reactomeId="164845" points="2162 2441, 2501 2390, 2629 2390" position="2501 2390" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="44" /> </Inputs> <Outputs> <Output id="63" points="2710 2381" /> <Output id="838" points="2709 2499" /> <Output id="840" stoichiometry="2" points="2653 2337" /> </Outputs> <Properties> <displayName>Suicidal integration leading to inverted circle formation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="241" reactomeId="167097" points="1893 1890, 1921 1891, 1949 1890" position="1921 1891" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="64" points="1878 1906" /> <Input id="65" points="1851 1876" /> </Inputs> <Outputs> <Output id="66" points="1978 1876" /> <Output id="67" points="2009 1898" /> <Output id="69" points="1974 1916" /> </Outputs> <Catalysts> <Catalyst id="68" points="1911 1954" /> </Catalysts> <Properties> <displayName>HIV Promoter Opening: First Transition</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="242" reactomeId="167095" points="2173 2025, 2131 2025, 2080 2025" position="2131 2025" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="71" points="2201 2023" /> <Input id="74" points="2181 2110" /> </Inputs> <Outputs> <Output id="72" /> </Outputs> <Properties> <displayName>Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the HIV-1promoter:TFIID:TFIIA:TFIIB complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="243" reactomeId="167110" points="1909 2043, 1864 2042, 1829 2043" position="1864 2042" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="72" points="1949 2035" /> <Input id="1266" points="1960 2075" /> </Inputs> <Outputs> <Output id="78" /> </Outputs> <Properties> <displayName>Binding of TFIIE to the growing HIV-1 preinitiation complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="244" reactomeId="167108" points="2497 2162, 2496 2079, 2496 2041" position="2496 2079" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="54" points="2476 2179" /> <Input id="75" points="2547 2183" /> </Inputs> <Outputs> <Output id="77" /> </Outputs> <Properties> <displayName>Recognition and Binding of Core HIV-1 Promoter Elements by TFIID</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="245" reactomeId="167135" points="1808 1998, 1806 1930, 1807 1876" position="1806 1930" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="78" points="1786 2015" /> <Input id="68" points="1873 1978" /> </Inputs> <Outputs> <Output id="65" /> </Outputs> <Properties> <displayName>Formation of the HIV-1 closed pre-initiation complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="246" reactomeId="167099" points="2395 2020, 2361 2021, 2312 2021" position="2361 2021" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="76" points="2420 2054" /> <Input id="77" points="2433 2020" /> <Input id="73" points="2418 1991" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> <Properties> <displayName>Binding of TFIIA and TFIIB to the HIV-1 promoter:TFIID complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="247" reactomeId="167118" points="2115 1856, 2138 1856, 2170 1856" position="2138 1856" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="66" points="2072 1855" /> <Input id="1697" stoichiometry="2" points="2088 1813" /> </Inputs> <Outputs> <Output id="80" /> </Outputs> <Properties> <displayName>NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="248" reactomeId="167134" points="2488 1897, 2515 1898, 2569 1896" position="2515 1898" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="81" /> </Inputs> <Outputs> <Output id="79" points="2647 1897" /> <Output id="189" points="2542 1841" /> </Outputs> <Properties> <displayName>Newly formed phosphodiester bond stabilized and PPi released</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="249" reactomeId="167130" points="2275 1855, 2305 1855, 2362 1875" position="2305 1855" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="80" /> </Inputs> <Outputs> <Output id="81" /> </Outputs> <Properties> <displayName>Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="250" reactomeId="167136" points="2761 1653, 2709 1651, 2676 1651" position="2709 1651" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="85" points="2794 1640" /> <Input id="1700" stoichiometry="5" points="2801 1699" /> </Inputs> <Outputs> <Output id="84" points="2603 1659" /> <Output id="139" points="2593 1610" /> <Output id="140" points="2601 1586" /> <Output id="142" points="2623 1555" /> <Output id="161" stoichiometry="5" points="2634 1697" /> </Outputs> <Catalysts> <Catalyst id="145" points="2709 1529" /> </Catalysts> <Properties> <displayName>Addition of nucleotides 5 through 9 on the growing HIV-1 transcript</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="251" reactomeId="167115" points="1883 1670, 1828 1669, 1782 1670" position="1828 1669" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="87" points="1940 1670" /> <Input id="1692" points="1937 1583" /> </Inputs> <Outputs> <Output id="88" points="1747 1670" /> <Output id="160" points="1767 1623" /> </Outputs> <Catalysts> <Catalyst id="148" points="1827 1710" /> </Catalysts> <Properties> <displayName>Addition of nucleotides between position +11 and +30 on HIV-1 transcript</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="252" reactomeId="167117" points="2350 1668, 2293 1668, 2232 1668" position="2293 1668" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="84" points="2467 1667" /> <Input id="1694" stoichiometry="2" points="2376 1710" /> </Inputs> <Outputs> <Output id="87" points="2076 1670" /> <Output id="159" stoichiometry="2" points="2195 1718" /> </Outputs> <Catalysts> <Catalyst id="146" points="2289 1622" /> </Catalysts> <Properties> <displayName>Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="253" reactomeId="167121" points="2865 1896, 2934 1894, 3041 1892" position="2934 1894" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="79" points="2777 1897" /> <Input id="1705" points="2825 1856" /> </Inputs> <Outputs> <Output id="86" points="3042 1760" /> <Output id="82" points="3018 1871" /> </Outputs> <Catalysts> <Catalyst id="144" points="2931 1969" /> </Catalysts> <Properties> <displayName>Addition of the third nucleotide on the nascent HIV-1 transcript</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="254" reactomeId="167113" points="3049 1636, 3000 1621, 2968 1621" position="3000 1621" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="86" points="3045 1690" /> <Input id="1703" points="3081 1627" /> </Inputs> <Outputs> <Output id="85" points="2930 1619" /> <Output id="141" points="2923 1565" /> <Output id="188" points="2945 1661" /> </Outputs> <Catalysts> <Catalyst id="147" points="3073 1552" /> </Catalysts> <Properties> <displayName>Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="255" reactomeId="167111" points="1611 1672, 1582 1672, 1560 1672" position="1582 1672" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="88" /> </Inputs> <Outputs> <Output id="89" /> </Outputs> <Properties> <displayName>Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="256" reactomeId="167153" points="1260 2070, 1260 2115, 1263 2148" position="1260 2115" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="91" points="1305 2056" /> <Input id="95" points="1260 2020" /> <Input id="339" points="1233 2064" /> </Inputs> <Outputs> <Output id="94" /> </Outputs> <Properties> <displayName>SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="257" reactomeId="167128" points="1259 1778, 1258 1814, 1262 1844" position="1258 1814" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="93" points="1293 1786" /> <Input id="96" points="1259 1732" /> </Inputs> <Outputs> <Output id="90" /> </Outputs> <Properties> <displayName>RNA Polymerase II CTD (phosphorylated) binds to CE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="258" reactomeId="167098" points="1405 1678, 1385 1674, 1356 1674" position="1385 1674" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="89" points="1424 1676" /> <Input id="1720" stoichiometry="13" points="1431 1719" /> </Inputs> <Outputs> <Output id="1721" stoichiometry="13" points="1339 1730" /> <Output id="96" points="1327 1674" /> </Outputs> <Catalysts> <Catalyst id="1292" points="1385 1602" /> </Catalysts> <Properties> <displayName>Phosphorylation (Ser5) of RNA pol II CTD</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="259" reactomeId="167133" points="1262 1900, 1259 1926, 1259 1950" position="1259 1926" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="90" /> </Inputs> <Outputs> <Output id="95" /> </Outputs> <Properties> <displayName>Activation of GT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="260" reactomeId="167083" points="1576 1238, 1606 1237, 1637 1239" position="1606 1237" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="100" points="1558 1262" /> <Input id="102" points="1558 1204" /> </Inputs> <Outputs> <Output id="97" /> </Outputs> <Properties> <displayName>DSIF complex binds to RNA Pol II (hypophosphorylated)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="261" reactomeId="167085" points="1798 1243, 1825 1243, 1853 1243" position="1825 1243" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="97" points="1773 1243" /> <Input id="101" points="1770 1191" /> <Input id="1690" points="1819 1299" /> </Inputs> <Outputs> <Output id="99" points="1876 1243" /> <Output id="1690" points="1830 1299" /> </Outputs> <Properties> <displayName>Formation of DSIF:NELF:HIV-1 early elongation complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="262" reactomeId="167072" points="1390 1219, 1428 1218, 1463 1219" position="1428 1218" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="98" points="1361 1219" /> <Input id="103" points="1382 1176" /> <Input id="143" points="1412 1251" /> </Inputs> <Outputs> <Output id="102" points="1492 1204" /> <Output id="143" points="1430 1251" /> </Outputs> <Catalysts> <Catalyst id="103" points="1401 1176, 1432 1189" /> </Catalysts> <Properties> <displayName>Hypophosphorylation of RNA Pol II CTD by FCP1P protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="263" reactomeId="167192" points="3555 1276, 3558 1328, 3560 1359" position="3558 1328" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="104" points="3442 1221" /> <Input id="1707" points="3598 1295" /> </Inputs> <Outputs> <Output id="106" points="3560 1393" /> <Output id="1707" points="3610 1328" /> </Outputs> <Properties> <displayName>Pol II elongation complex moves on the HIV-1 template as transcript elongates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="264" reactomeId="167181" points="3370 1072, 3371 1100, 3372 1127" position="3371 1100" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="105" points="3304 1046" /> <Input id="1710" points="3407 1047" /> </Inputs> <Outputs> <Output id="104" points="3373 1156" /> <Output id="158" points="3273 1152" /> </Outputs> <Properties> <displayName>Addition of nucleotides leads to HIV-1 transcript elongation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="265" reactomeId="167197" points="3561 1449, 3561 1483, 3561 1517" position="3561 1483" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="106" /> </Inputs> <Outputs> <Output id="107" /> </Outputs> <Properties> <displayName>Separation of elongating HIV-1 transcript from template</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="266" reactomeId="167087" points="2013 1499, 2079 1499, 2121 1499" position="2079 1499" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="99" points="1948 1266" /> <Input id="1692" points="1962 1546" /> </Inputs> <Outputs> <Output id="109" /> </Outputs> <Properties> <displayName>Limited elongation of the HIV-1 transcript</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="267" reactomeId="167147" points="2257 1497, 2299 1496, 2337 1496" position="2299 1496" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="109" /> </Inputs> <Outputs> <Output id="108" /> </Outputs> <Properties> <displayName>Separation of abortive HIV-1 transcript from template</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="268" reactomeId="165055" points="1641 597, 1687 597, 1741 595" position="1687 597" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="119" /> </Inputs> <Outputs> <Output id="120" points="1766 616" /> <Output id="122" points="1758 574" /> </Outputs> <Catalysts> <Catalyst id="127" points="1401 778" /> </Catalysts> <Activators> <Activator id="111" points="1620 863" /> <Activator id="123" points="1710 667" /> </Activators> <Properties> <displayName>Hydrolysis of Ran:GTP to Ran:GDP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="269" reactomeId="180885" points="1754 1032, 1715 1031, 1665 1031" position="1715 1031" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="112" points="1799 1068" /> <Input id="130" points="1791 1029" /> </Inputs> <Outputs> <Output id="117" /> </Outputs> <Properties> <displayName>Rev multimer-bound HIV mRNA associates with Crm1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="270" reactomeId="165027" points="2180 1059, 2124 1061" position="2124 1061" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="116" points="2205 1003" /> <Input id="340" points="2204 1071" /> </Inputs> <Outputs> <Output id="125" /> </Outputs> <Properties> <displayName>Rev molecules assemble onto the RRE RNA sequence through their ARM sequence</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="271" reactomeId="165043" points="1330 918, 1289 919, 1245 905" position="1289 919" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="126" points="1346 906" /> <Input id="113" points="1345 932" /> </Inputs> <Outputs> <Output id="131" /> </Outputs> <Properties> <displayName>Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="272" reactomeId="165047" points="1245 866, 1285 853, 1319 852" position="1285 853" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="131" /> </Inputs> <Outputs> <Output id="126" points="1338 862" /> <Output id="127" points="1339 834" /> </Outputs> <Properties> <displayName>Translocation of nuclear RNA transport complex to cytoplasm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="273" reactomeId="165028" points="1432 636, 1442 619, 1465 580" position="1442 619" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="128" /> </Inputs> <Outputs> <Output id="118" points="1572 547" /> <Output id="129" points="1511 545" /> <Output id="341" points="1438 550" /> <Output id="119" points="1571 593" /> <Output id="110" points="1205 672" /> <Output id="111" points="1612 863" /> </Outputs> <Properties> <displayName>Release of the HIV mRNA and Crm1 from Rev in the cytoplasm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="274" reactomeId="180739" points="1421 748, 1421 727, 1420 692" position="1421 727" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="127" points="1388 778" /> <Input id="111" points="1601 863" /> </Inputs> <Outputs> <Output id="128" /> </Outputs> <Properties> <displayName>Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="275" reactomeId="165033" points="2000 1024, 1957 1024, 1927 1024" position="1957 1024" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="114" points="2023 1007" /> <Input id="125" points="2030 1043" /> </Inputs> <Outputs> <Output id="130" /> </Outputs> <Properties> <displayName>Multimerization of Rev</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="276" reactomeId="165034" points="1525 965, 1486 963, 1436 961" position="1486 963" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="117" points="1570 1004" /> <Input id="121" points="1550 959" /> </Inputs> <Outputs> <Output id="113" /> </Outputs> <Properties> <displayName>Rev multimer-bound HIV mRNA:CRM1 complex associates with Ran:GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="277" reactomeId="167196" points="3107 1024, 3133 1024, 3168 1023" position="3133 1024" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="170" points="2904 1040" /> <Input id="166" points="2895 974" /> <Input id="174" points="2887 1007" /> <Input id="168" points="2877 1082" /> <Input id="169" points="2981 1159" /> <Input id="176" points="3038 976" /> </Inputs> <Outputs> <Output id="105" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="278" reactomeId="167234" points="2100 1363, 2130 1364, 2162 1363" position="2130 1364" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="420" points="2075 1337" /> <Input id="164" points="2084 1381" /> </Inputs> <Outputs> <Output id="165" /> </Outputs> <Properties> <displayName>Association of Tat with P-TEFb(Cyclin T1:Cdk9)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="279" reactomeId="170706" points="2510 1299, 2549 1299, 2588 1299" position="2549 1299" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="167" points="2462 1296" /> <Input id="177" points="2501 1316" /> </Inputs> <Outputs> <Output id="173" points="2628 1269" /> <Output id="197" points="2602 1314" /> </Outputs> <Catalysts> <Catalyst id="167" points="2462 1280, 2550 1261" /> </Catalysts> <Properties> <displayName>Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="280" reactomeId="170704" points="2771 1227, 2800 1226, 2835 1227" position="2800 1226" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="173" points="2754 1225" /> <Input id="163" points="2761 1278" /> </Inputs> <Outputs> <Output id="169" points="2865 1222" /> <Output id="175" points="2848 1275" /> </Outputs> <Catalysts> <Catalyst id="173" points="2754 1204, 2800 1193" /> </Catalysts> <Properties> <displayName>Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="281" reactomeId="167191" points="2200 1256, 2221 1249, 2273 1258" position="2221 1249" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="99" points="2012 1247" /> <Input id="165" points="2220 1342" /> <Input id="1713" stoichiometry="11" points="2175 1278" /> </Inputs> <Outputs> <Output id="1714" stoichiometry="11" points="2286 1295" /> <Output id="167" points="2326 1274" /> <Output id="171" points="2300 1225" /> </Outputs> <Catalysts> <Catalyst id="165" points="2224 1342" /> </Catalysts> <Properties> <displayName>Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="282" reactomeId="167284" points="3419 1717, 3477 1733, 3520 1744" position="3477 1733" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="179" /> </Inputs> <Outputs> <Output id="180" /> </Outputs> <Properties> <displayName>7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="283" reactomeId="167288" points="3520 1774, 3462 1788, 3373 1722" position="3462 1788" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="180" /> </Inputs> <Outputs> <Output id="179" /> </Outputs> <Properties> <displayName>TFIIS-mediated recovery of HIV-1 elongation from arrest</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="284" reactomeId="167084" points="2011 1211, 2057 1199, 2195 1154" position="2057 1199" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="99" points="1979 1224" /> <Input id="181" points="1970 1180" /> <Input id="1718" stoichiometry="11" points="1935 1202" /> </Inputs> <Outputs> <Output id="1719" stoichiometry="11" points="2224 1192" /> <Output id="182" points="2334 1110" /> <Output id="171" points="2272 1180" /> </Outputs> <Catalysts> <Catalyst id="181" points="2020 1164, 2056 1164" /> </Catalysts> <Properties> <displayName>Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="285" reactomeId="167077" points="2587 1031, 2587 1066, 2587 1100" position="2587 1066" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="166" points="2810 974" /> <Input id="170" points="2796 1041" /> <Input id="174" points="2802 1008" /> <Input id="168" points="2788 1082" /> <Input id="182" points="2470 1069" /> <Input id="1027" points="2568 988" /> </Inputs> <Outputs> <Output id="183" /> </Outputs> <Properties> <displayName>Recruitment of elongation factors to form HIV-1 elongation complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="286" reactomeId="167282" points="3353 1722, 3367 1814, 3357 1843" position="3367 1814" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="179" /> </Inputs> <Outputs> <Output id="184" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="287" reactomeId="167292" points="3339 1843, 3327 1815, 3347 1722" position="3327 1815" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="184" /> </Inputs> <Outputs> <Output id="179" /> </Outputs> <Properties> <displayName>Resumption of elongation of HIV-1 transcript after recovery from pausing</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="288" reactomeId="167148" points="3404 1385, 3427 1335, 3385 1226" position="3427 1335" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="104" /> </Outputs> <Properties> <displayName>TFIIS-mediated recovery of elongation from arrest</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="289" reactomeId="167090" points="3364 1226, 3333 1336, 3369 1385" position="3333 1336" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="104" /> </Inputs> <Outputs> <Output id="185" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="290" reactomeId="167076" points="3351 1226, 3272 1338, 3244 1381" position="3272 1338" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="104" /> </Inputs> <Outputs> <Output id="186" /> </Outputs> <Properties> <displayName>2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="291" reactomeId="167150" points="3231 1381, 3241 1325, 3342 1226" position="3241 1325" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="186" /> </Inputs> <Outputs> <Output id="104" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="292" reactomeId="167484" points="1948 1853, 1905 1853, 1871 1853" position="1905 1853" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="66" /> </Inputs> <Outputs> <Output id="65" /> </Outputs> <Properties> <displayName>Fall Back to Closed Pre-initiation Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="293" reactomeId="167477" points="2711 1923, 2710 2003, 2713 2122" position="2710 2003" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="79" /> </Inputs> <Outputs> <Output id="74" points="2252 2136" /> <Output id="187" points="2744 2141" /> <Output id="1268" points="2790 2087" /> <Output id="1270" points="2687 2156" /> <Output id="1272" points="2685 2082" /> <Output id="1275" points="2674 2105" /> <Output id="1279" points="2772 2061" /> </Outputs> <Properties> <displayName>Abortive HIV-1 initiation after formation of the first phosphodiester bond</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="294" reactomeId="167474" points="1484 2282, 1517 2282, 1548 2282" position="1517 2282" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="190" /> </Inputs> <Outputs> <Output id="70" points="1573 2238" /> <Output id="191" points="1688 2295" /> <Output id="74" points="2116 2152" /> <Output id="1273" points="1609 2339" /> <Output id="1286" points="1565 2352" /> <Output id="1288" points="1626 2318" /> <Output id="1290" points="1626 2237" /> </Outputs> <Properties> <displayName>Abortive HIV-1 Initiation Before Second Transition</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="295" reactomeId="167481" points="3588 1788, 3589 1815, 3589 1843" position="3589 1815" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="180" /> </Inputs> <Outputs> <Output id="192" /> </Outputs> <Properties> <displayName>Abortive termination of HIV-1 elongation after arrest</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="296" reactomeId="167478" points="1940 1266, 1923 1341, 1897 1459" position="1923 1341" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="99" /> </Inputs> <Outputs> <Output id="193" /> </Outputs> <Properties> <displayName>Abortive termination of HIV-1 early transcription elongation by DSIF:NELF</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="297" reactomeId="167468" points="1523 1970, 1547 1970, 1575 1971" position="1547 1970" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="194" /> </Inputs> <Outputs> <Output id="195" points="1618 1950" /> <Output id="68" points="1873 1968" /> <Output id="74" points="2116 2137, 1675 2135" /> <Output id="1277" points="1569 1938" /> </Outputs> <Properties> <displayName>Abortive HIV-1 Initiation After Second Transition</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="298" reactomeId="167459" points="3391 1452, 3392 1482, 3392 1534" position="3392 1482" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="196" /> </Outputs> <Properties> <displayName>Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="299" reactomeId="180687" points="1820 945, 1738 946, 1692 946" position="1738 946" lineWidth="1.0" lineColor="255 0 0"> <Inputs> <Input id="198" points="1822 954" /> <Input id="199" points="1826 933" /> </Inputs> <Outputs> <Output id="200" points="1672 964" /> <Output id="121" points="1621 945" /> </Outputs> <Catalysts> <Catalyst id="201" points="1736 924" /> </Catalysts> <Properties> <displayName>Conversion of Ran-GDP to Ran-GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="300" reactomeId="167089" points="1292 1126, 1290 1159, 1291 1187" position="1290 1159" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="202" points="1261 1101" /> <Input id="203" points="1347 1086" /> </Inputs> <Outputs> <Output id="98" /> </Outputs> <Properties> <displayName>Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="301" reactomeId="187213" points="1056 704, 900 722, 763 722" position="900 722" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="110" /> </Inputs> <Outputs> <Output id="464" /> </Outputs> <Properties> <displayName>Synthesis of GAG polyprotein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="312" reactomeId="184269" points="584 422, 585 405, 585 382" position="585 405" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="396" /> </Inputs> <Outputs> <Output id="1144" /> </Outputs> <Catalysts> <Catalyst id="308" points="710 363" /> </Catalysts> <Properties> <displayName>Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="313" reactomeId="184323" points="585 532, 585 512, 583 478" position="585 512" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="306" points="559 548" /> <Input id="394" points="629 537" /> </Inputs> <Outputs> <Output id="396" /> </Outputs> <Properties> <displayName>Monoubiquitination of N-myristoyl GAG polyprotein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="314" reactomeId="184392" points="751 657, 750 629, 751 593" position="750 629" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="464" points="715 702" /> <Input id="310" points="784 669" /> </Inputs> <Outputs> <Output id="394" points="714 566" /> <Output id="305" points="798 553" /> </Outputs> <Catalysts> <Catalyst id="304" points="732 629" /> </Catalysts> <Properties> <displayName>N-myristoylation of GAG polyprotein by NMT2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="328" reactomeId="162914" points="863 640, 863 614, 862 585" position="863 614" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="310" points="832 669" /> <Input id="367" points="894 669" /> </Inputs> <Outputs> <Output id="357" points="1234 524" /> <Output id="305" points="829 553" /> </Outputs> <Catalysts> <Catalyst id="342" points="884 614" /> </Catalysts> <Properties> <displayName>Myristoylation of Nef</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="506" reactomeId="3139027" points="949 147, 862 147, 222 150" position="862 147" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="507" /> </Inputs> <Outputs> <Output id="17" /> </Outputs> <Catalysts> <Catalyst id="508" points="861 114" /> </Catalysts> <Inhibitors> <Inhibitor id="1548" points="788 127" /> </Inhibitors> <Properties> <displayName>Maturation of HIV Virion</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="518" reactomeId="174488" points="1129 676, 1129 649, 1129 617" position="1129 649" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="110" /> </Inputs> <Outputs> <Output id="519" /> </Outputs> <Properties> <displayName>Synthesis of GAGPOL polyprotein by ribosomal frameshifting</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="574" reactomeId="189305" points="1130 561, 1131 489, 1131 280" position="1131 489" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="519" /> </Inputs> <Outputs> <Output id="575" /> </Outputs> <Catalysts> <Catalyst id="576" points="1096 491" /> </Catalysts> <Properties> <displayName>Transport of GAGPOL precursor to plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="577" reactomeId="187211" points="2215 975, 2216 886, 2212 790" position="2216 886" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="116" /> </Inputs> <Outputs> <Output id="578" /> </Outputs> <Properties> <displayName>Splicing of HIV RNA transcript</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="579" reactomeId="174494" points="2143 766, 2081 765, 2005 728" position="2081 765" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="578" /> </Inputs> <Outputs> <Output id="580" /> </Outputs> <Properties> <displayName>Synthesis of ENV polyprotein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="581" reactomeId="174493" points="2002 672, 2037 655, 2039 699, 2012 699" position="2037 655" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="580" /> </Inputs> <Outputs> <Output id="580" /> </Outputs> <Properties> <displayName>Glycosylation of ENV polyprotein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="770" reactomeId="171291" points="1958 672, 1958 633, 1958 609" position="1958 633" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="580" stoichiometry="3" /> </Inputs> <Outputs> <Output id="771" /> </Outputs> <Properties> <displayName>Folding and Oligomerization of ENV glycoprotein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="772" reactomeId="174491" points="1958 567, 1958 521, 1958 490" position="1958 521" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="771" /> </Inputs> <Outputs> <Output id="773" /> </Outputs> <Properties> <displayName>Transport of trimeric ENV precursor to Golgi apparatus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="774" reactomeId="171288" points="1959 448, 1959 426, 1962 403" position="1959 426" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="773" /> </Inputs> <Outputs> <Output id="776" /> </Outputs> <Catalysts> <Catalyst id="1234" points="1904 427" /> </Catalysts> <Properties> <displayName>Cleavage of the viral Env gp160 precursor polyprotein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="781" reactomeId="173647" points="1963 361, 1962 330, 1964 270" position="1962 330" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="776" /> </Inputs> <Outputs> <Output id="782" /> </Outputs> <Properties> <displayName>Transport of trimeric gp41:gp120 to plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="783" reactomeId="3149433" points="2192 748, 2159 697, 2120 645" position="2159 697" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="578" /> </Inputs> <Outputs> <Output id="784" /> </Outputs> <Properties> <displayName>Synthesis of VPU protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="785" reactomeId="3149440" points="2112 617, 2111 519, 2112 413" position="2111 519" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="784" /> </Inputs> <Outputs> <Output id="786" /> </Outputs> <Properties> <displayName>Transport of VPU to Golgi apparatus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="829" reactomeId="3149432" points="2113 367, 2114 326, 2115 268" position="2114 326" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="786" /> </Inputs> <Outputs> <Output id="830" /> </Outputs> <Properties> <displayName>Transport of VPU to Plasma Membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="889" reactomeId="3149434" points="584 326, 582 303, 581 279" position="582 303" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="1144" /> </Inputs> <Outputs> <Output id="1159" /> </Outputs> <Catalysts> <Catalyst id="308" points="706 339" /> </Catalysts> <Properties> <displayName>Transport of GAG to the Plasma Membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="991" reactomeId="3149454" points="1367 346, 1366 297, 1367 266" position="1366 297" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="1000" points="1670 387" /> <Input id="575" points="1179 269" /> <Input id="782" points="1907 257" /> <Input id="830" points="2068 268, 1914 301" /> <Input id="357" points="1309 486" /> <Input id="341" points="1418 508" /> <Input id="1159" points="645 258" /> <Input id="999" points="1566 431" /> <Input id="1001" points="1622 353" /> <Input id="1008" points="1564 397" /> <Input id="1006" points="1471 430" /> </Inputs> <Outputs> <Output id="992" /> </Outputs> <Properties> <displayName>Packaging of HIV virion on the host cell plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1127" reactomeId="3159232" points="987 351, 988 327, 988 274" position="988 327" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="308" points="776 349" /> <Input id="1131" points="920 369" /> <Input id="1129" points="953 396" /> <Input id="1130" points="1023 388" /> <Input id="1128" points="1010 352" /> </Inputs> <Outputs> <Output id="1196" /> </Outputs> <Properties> <displayName>Recruitment Of HIV Virion Budding Machinery</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1229" reactomeId="3159227" points="1316 224, 1111 156, 1057 151" position="1111 156" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="992" /> </Inputs> <Outputs> <Output id="507" /> </Outputs> <Activators> <Activator id="1196" points="1011 232" /> </Activators> <Properties> <displayName>HIV Virion Budding</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1493" reactomeId="8951690" points="698 2227, 699 2254, 700 2280" position="699 2254" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Transition"> <Inputs> <Input id="337" points="530 2233" /> <Input id="45" points="609 2183" /> <Input id="336" points="532 2192" /> <Input id="10" points="720 2192" /> </Inputs> <Outputs> <Output id="1494" /> </Outputs> <Properties> <displayName>Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1495" reactomeId="9613498" points="2708 1839, 2671 1818, 2644 1831" position="2671 1818" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="79" points="2710 1875" /> <Input id="1705" points="2776 1837" /> </Inputs> <Outputs> <Output id="79" points="2691 1875" /> <Output id="189" points="2557 1824" /> </Outputs> <Catalysts> <Catalyst id="157" points="2728 1788" /> </Catalysts> <Properties> <displayName>Unwinding of DNA for the nascent HIV-1 transcript</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1496" reactomeId="9613490" points="2894 1744, 2893 1777, 2946 1776" position="2893 1777" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="86" points="2975 1733" /> <Input id="1700" points="2850 1727" /> </Inputs> <Outputs> <Output id="82" points="2993 1835" /> <Output id="86" points="2982 1760" /> </Outputs> <Catalysts> <Catalyst id="157" points="2777 1772" /> </Catalysts> <Properties> <displayName>Unwinding of DNA for the nascent HIV-1 transcript: Second Transition</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1543" interactionType="Activate" points="1030 1480, 1001 1504" position="1015 1492" lineWidth="2.0"> <Inputs> <Input id="1523" /> </Inputs> <Outputs> <Output id="1542" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1571" reactomeId="9697043" points="782 70, 782 71, 750 91" position="782 71" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="508" points="817 77" /> <Input id="1572" points="738 41" /> </Inputs> <Outputs> <Output id="1548" /> </Outputs> <Properties> <displayName>Protease binds protease inhibitors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1647" reactomeId="9697051" points="648 1485, 648 1485, 688 1515" position="648 1485" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="4" points="686 1477" /> <Input id="1648" points="614 1469" /> </Inputs> <Outputs> <Output id="1551" /> </Outputs> <Properties> <displayName>RTC binds NRTIs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1649" reactomeId="9724270" points="372 223, 372 223, 410 233" position="372 223" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1650" points="339 236" /> <Input id="1651" points="334 204" /> </Inputs> <Outputs> <Output id="1652" /> </Outputs> <Properties> <displayName>CCR5 inhibitors bind to CCR5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1687" reactomeId="9731500" points="1008 2594, 1008 2621, 1009 2701" position="1008 2621" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="47" points="1052 2508" /> <Input id="1688" points="950 2572" /> </Inputs> <Outputs> <Output id="1689" /> </Outputs> <Properties> <displayName>IN bound to sticky 3' ends in PIC binds INSTIs</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of HIV Life Cycle (451240)