Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person IDH2 dimer decarboxylates isocitrate

Class:Id	Reaction:450984
_displayName	IDH2 dimer decarboxylates isocitrate
_doRelease	TRUE
_timestamp	2024-04-24 07:25:53
authored	[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
catalystActivity	[CatalystActivity:450976] isocitrate dehydrogenase (NADP+) activity of IDH2 dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643209] isocitrate dehydrogenase (NADP+) activity of IDH2 dimer [mitochondrial matrix] Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:450991] D'Eustachio, P, 2009-12-24
crossReference	[DatabaseIdentifier:9854181] RHEA:19629
input	[SimpleEntity:29938] ISCIT [mitochondrial matrix] [SimpleEntity:113563] NADP+ [mitochondrial matrix]
internalReviewed	[InstanceEdit:9856153] D'Eustachio, Peter, 2023-12-12
isChimeric	FALSE
literatureReference	[LiteratureReference:451000] Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism [LiteratureReference:450998] Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle [LiteratureReference:450968] Di- and triphosphopyridine nucleotide isocitric dehydrogenases in yeast [LiteratureReference:450970] Biosynthesis of tricarboxylic acids by carbon dioxide fixation; enzymatic mechanisms [LiteratureReference:9853650] Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase [LiteratureReference:9853642] IDH2 mutations in patients with D-2-hydroxyglutaric aciduria
modified	[InstanceEdit:451020] D'Eustachio, P, 2009-12-24 [InstanceEdit:451044] D'Eustachio, P, 2009-12-26 [InstanceEdit:451051] D'Eustachio, P, 2009-12-26 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9853494] Stephan, Ralf, 2023-11-16 [InstanceEdit:9853635] Stephan, Ralf, 2023-11-20 [InstanceEdit:9853653] Stephan, Ralf, 2023-11-20 [InstanceEdit:9854201] Stephan, Ralf, 2023-11-23 [InstanceEdit:9855772] Stephan, Ralf, 2023-12-07 [InstanceEdit:9856154] Stephan, Ralf, 2023-12-12 [InstanceEdit:9861237] D'Eustachio, Peter, 2024-02-15 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24
name	IDH2 dimer decarboxylates isocitrate D-threo-isocitrate + NADP(+) => 2-oxoglutarate + CO2 + NADPH
output	[SimpleEntity:113594] 2OG [mitochondrial matrix] [SimpleEntity:29376] CO2 [mitochondrial matrix] [SimpleEntity:113600] NADPH [mitochondrial matrix]
precedingEvent	[Reaction:70971] ACO2 isomerizes citrate [Homo sapiens] [Reaction:70975] CS acetylates OA to citrate [Homo sapiens] [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens] [Reaction:450984] IDH2 dimer decarboxylates isocitrate [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[NegativeRegulation:9855774] Negative regulation by 'AcK-IDH2 dimer [mitochondrial matrix]'
regulationReference	[RegulationReference:9855773] Negative regulation by 'AcK-IDH2 dimer [mitochondrial matrix]' Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells
releaseDate	2008-06-30
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105135] R-HSA-450984.6
structureModified	[InstanceEdit:9853494] Stephan, Ralf, 2023-11-16 [InstanceEdit:9855772] Stephan, Ralf, 2023-12-07
summation	[Summation:450992] Mitochondrial isocitrate dehydrogenase IDH2 catalyzes the ir...
(hasEvent)	[Pathway:71403] Citric acid cycle (TCA cycle) [Homo sapiens]
(precedingEvent)	[Reaction:71401] OGDH dimer decarboxylates 2-OG [Homo sapiens] [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens] [Reaction:1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol [Homo sapiens] [Reaction:1237047] CA4:Zn2+ hydrates CO2 to HCO3- [Homo sapiens] [Reaction:1237069] RHAG transports CO2 from extracellular region to cytosol [Homo sapiens] [Reaction:1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) [Homo sapiens] [Reaction:1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) [Homo sapiens] [Reaction:1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9864187] Update Tracker - [Reaction:450984] IDH2 dimer decarboxylates isocitrate - v88:[addLiteratureReference, addRegulator, modifyText, removeOutput]
[Change default viewing format]

No pathways have been reviewed or authored by IDH2 dimer decarboxylates isocitrate (450984)