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Details on Person NNT (nicotinamide nucleotide transhydrogenase) associated wi...
| Class:Id | Summation:450983 |
|---|---|
| _displayName | NNT (nicotinamide nucleotide transhydrogenase) associated wi... |
| _timestamp | 2023-11-20 09:50:41 |
| created | [InstanceEdit:450991] D'Eustachio, P, 2009-12-24 |
| modified | [InstanceEdit:451020] D'Eustachio, P, 2009-12-24 [InstanceEdit:9853635] Stephan, Ralf, 2023-11-20 |
| text | NNT (nicotinamide nucleotide transhydrogenase) associated with the inner mitochondrial membrane catalyzes the reaction of mitochondrial NADPH and NAD+ to form NADP+ and NADH. The reaction is coupled to the translocation of a proton across the inner mitochondrial membrane into the mitochondrial matrix (Arkblad et al., 1996; White et al., 2000). The active form of NNT is inferred to be a homodimer based on the known structure of its bovine homolog (Yamaguchi & Hatefi, 1991) and the structure of the ovine homolog (Kampjut & Sazanow, 2019). Mutations in NNT can lead to glucocorticoid deficiency (GCCD4; MIM:614736; reviewed in Francisco et al., 2021). |
| (summation) | [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens] |
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No pathways have been reviewed or authored by NNT (nicotinamide nucleotide transhydrogenase) associated wi... (450983)
