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Details on Person Diagram of Intrinsic Pathway for Apoptosis and Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
| Class:Id | PathwayDiagram:450953 |
|---|---|
| _displayName | Diagram of Intrinsic Pathway for Apoptosis and Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function |
| _timestamp | 2021-02-24 22:23:01 |
| created | [InstanceEdit:450946] Matthews, L, 2009-12-23 |
| height | 1718 |
| modified | [InstanceEdit:1679954] Wu, G, 2011-10-20 [InstanceEdit:1866237] Rothfels, K, 2011-10-31 [InstanceEdit:2193078] Wu, G, 2012-04-11 [InstanceEdit:3076322] D'Eustachio, P, 2013-02-06 [InstanceEdit:3142702] Orlic-Milacic, M, 2013-02-13 [InstanceEdit:3142706] Orlic-Milacic, M, 2013-02-13 [InstanceEdit:3143413] Orlic-Milacic, M, 2013-02-13 [InstanceEdit:3144193] Orlic-Milacic, M, 2013-02-13 [InstanceEdit:3145028] Orlic-Milacic, M, 2013-02-13 [InstanceEdit:3145741] Orlic-Milacic, M, 2013-02-14 [InstanceEdit:3145742] Orlic-Milacic, M, 2013-02-14 [InstanceEdit:3145743] Orlic-Milacic, M, 2013-02-14 [InstanceEdit:4217521] Orlic-Milacic, M, 2013-08-15 [InstanceEdit:4331346] Orlic-Milacic, M, 2013-08-16 [InstanceEdit:6791280] Orlic-Milacic, Marija, 2015-08-20 [InstanceEdit:6809579] Shamovsky, Veronica, 2015-11-11 [InstanceEdit:6809580] Shamovsky, Veronica, 2015-11-12 [InstanceEdit:6810440] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:6810445] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:8858368] Orlic-Milacic, Marija, 2016-02-18 [InstanceEdit:8940203] Orlic-Milacic, Marija, 2016-09-23 [InstanceEdit:9029245] Orlic-Milacic, Marija, 2017-11-14 [InstanceEdit:9029386] Orlic-Milacic, Marija, 2017-11-17 [InstanceEdit:9029410] Orlic-Milacic, Marija, 2017-11-17 [InstanceEdit:9612919] Orlic-Milacic, Marija, 2018-07-03 [InstanceEdit:9612920] Orlic-Milacic, Marija, 2018-07-03 [InstanceEdit:9628211] Shamovsky, Veronica, 2018-11-07 [InstanceEdit:9637920] D'Eustachio, Peter, 2019-02-21 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9645720] Orlic-Milacic, Marija, 2019-05-17 [InstanceEdit:9645775] Orlic-Milacic, Marija, 2019-05-17 [InstanceEdit:9645776] Orlic-Milacic, Marija, 2019-05-17 [InstanceEdit:9648377] Orlic-Milacic, Marija, 2019-06-06 [InstanceEdit:9648378] Orlic-Milacic, Marija, 2019-06-06 [InstanceEdit:9692328] Jassal, Bijay, 2020-06-22 [InstanceEdit:9716661] Shamovsky, Veronica, 2021-02-23 [InstanceEdit:9716662] Shamovsky, Veronica, 2021-02-23 [InstanceEdit:9716782] Orlic-Milacic, Marija, 2021-02-24 |
| representedPathway | [Pathway:109606] Intrinsic Pathway for Apoptosis [Homo sapiens] [Pathway:9645722] Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function [Homo sapiens] |
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<org.gk.render.RenderableProtein id="2428" reactomeId="140525" position="242 686" bounds="205 675 75 22" textPosition="205 675"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.21333333333333335" relativeY="0.0" label="P" trackId="0" reactomeId="140205" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2431" reactomeId="3145027" position="914 679" bounds="877 668 75 22" textPosition="877 668"> <Properties> <displayName>p-BCL2L11</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.21333333333333335" relativeY="0.0" label="P" trackId="0" reactomeId="140205" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2432" reactomeId="3145026" position="906 715" bounds="882 704 49 22" textPosition="883 704"> <Properties> <displayName>p-BMF</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.32653061224489793" relativeY="0.0" label="P" trackId="0" reactomeId="140210" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="2456" reactomeId="7660" position="464 357" bounds="249 68 431 578" textPosition="268 554" bgColor="250 240 240" lineColor="255 153 102" insets="260 79 410 557"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="136" /> <Component id="137" /> <Component id="2470" /> <Component id="2475" /> <Component id="2461" /> <Component id="2483" /> <Component id="2487" /> <Component id="2490" /> <Component id="2491" /> <Component id="2493" /> <Component id="2494" /> <Component id="2465" /> <Component id="134" /> <Component id="142" /> <Component id="140" /> <Component id="2506" /> <Component id="2505" /> <Component id="2787" /> <Component id="2786" /> <Component id="2791" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableGene id="2461" reactomeId="4331320" position="348 345" bounds="311 307 74 51" textPosition="313 334"> <Properties> <displayName>BBC3 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2465" reactomeId="4331345" position="564 241" bounds="501 202 126 78" textPosition="505 203" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="2470" reactomeId="4331342" position="383 521" bounds="338 483 90 51" textPosition="340 510"> <Properties> <displayName>PMAIP1 Gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2475" reactomeId="4331332" position="569 601" bounds="510 576 119 50" textPosition="513 577" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S15,S20-TP53 Tetramer:PMAIP1 Gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2483" reactomeId="4331325" position="552 399" bounds="494 381 116 36" textPosition="494 382" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>E2F1:TFDP1:BBC3 Gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2487" reactomeId="4331338" position="560 455" bounds="495 437 131 36" textPosition="495 438" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>E2F1:TFDP1:PMAIP1 Gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2496" reactomeId="6804299" position="2282 546" bounds="2221 528 123 36" textPosition="2234 529" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CASP3(1-277) dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2497" reactomeId="113592" position="2367 515" bounds="2347 500 40 30" textPosition="2351 504" /> <org.gk.render.RenderableChemical id="2498" reactomeId="29370" position="2465 568" bounds="2444 553 42 30" textPosition="2449 557" /> <org.gk.render.RenderableComplex id="2499" reactomeId="350870" position="2427 461" bounds="2390 450 75 22" textPosition="2391 451" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Caspase-3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2500" reactomeId="6804324" position="2606 526" bounds="2545 508 123 36" textPosition="2558 509" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CASP7(2-303) dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2501" reactomeId="113592" position="2696 553" bounds="2676 538 40 30" textPosition="2680 542" /> <org.gk.render.RenderableComplex id="2505" reactomeId="6799788" position="339 258" bounds="279 226 121 64" textPosition="281 227" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2506" reactomeId="3222171" position="407 605" bounds="352 587 111 36" textPosition="351 588" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S15,S20-TP53 Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="2531" reactomeId="9029242" position="1917 576" bounds="1854 558 126 36" textPosition="1857 558"> <Properties> <displayName>Activated BAX,BAK oligomers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2787" reactomeId="6790035" position="393 148" bounds="330 130 127 36" textPosition="331 130"> <Properties> <displayName>BCL2 gene, BCL2L1 gene</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2788" reactomeId="879209" position="997 398" bounds="950 387 94 22" textPosition="952 387"> <Properties> <displayName>Bcl-2/Bcl-X(L)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="2791" reactomeId="1112525" position="590 111" bounds="526 93 129 36" textPosition="539 94" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y705-STAT3 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2792" reactomeId="113592" position="227 912" bounds="207 897 40 30" textPosition="211 901" /> <org.gk.render.RenderableChemical id="2793" reactomeId="29370" position="219 1034" bounds="198 1019 42 30" textPosition="203 1023" /> <org.gk.render.RenderableChemical id="2812" reactomeId="113592" position="226 754" bounds="206 739 40 30" textPosition="210 743" /> <org.gk.render.RenderableChemical id="2813" reactomeId="29370" position="220 654" bounds="199 639 42 30" textPosition="204 643" /> <org.gk.render.RenderableChemical id="2814" reactomeId="113592" position="2121 901" bounds="2099 888 45 26" textPosition="2106 890" /> <org.gk.render.RenderableComplex id="2815" reactomeId="9627055" position="2053 873" bounds="2015 862 76 22" textPosition="2016 863" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>APAF1:ADP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2816" reactomeId="6804555" position="2291 875" bounds="2236 864 110 22" textPosition="2238 865" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>APAF1:ATP:CYCS</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2817" reactomeId="29370" position="2221 907" bounds="2200 892 42 30" textPosition="2205 896" /> <org.gk.render.RenderableComplex id="2818" reactomeId="6804619" position="2522 877" bounds="2465 859 114 36" textPosition="2467 860" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>APAF1:ATP:CYCS heptamer:CASP9</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2819" reactomeId="6805447" position="2466 813" bounds="2441 802 50 22" textPosition="2441 802"> <Properties> <displayName>CARD8</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2820" reactomeId="1237171" position="2488 941" bounds="2470 930 36 22" textPosition="2471 930"> <Properties> <displayName>APIP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2821" reactomeId="6805514" position="2097 957" bounds="2077 946 41 22" textPosition="2077 946"> <Properties> <displayName>AVEN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2822" reactomeId="6804630" position="2818 874" bounds="2755 856 127 36" textPosition="2755 857" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>APAF1:CYCS:ATP:CASP9(1-416)dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2823" reactomeId="50849" position="2207 615" bounds="2189 604 36 22" textPosition="2190 604"> <Properties> <displayName>XIAP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2824" reactomeId="9627054" position="2300 198" bounds="2254 187 92 22" textPosition="2256 188" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>DIABLO dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2825" reactomeId="9627066" position="2525 231" bounds="2468 220 115 22" textPosition="2470 221" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>XIAP:apoptosome</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2826" reactomeId="9627391" position="2867 166" bounds="2805 155 124 22" textPosition="2808 156" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>DIABLO dimer:XIAP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2874" reactomeId="6804605" position="2524 1025" bounds="2468 1007 113 36" textPosition="2470 1008" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>APAF1:CYCS:ATP:APIP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2876" reactomeId="6805523" position="2051 1027" bounds="2010 1016 83 22" textPosition="2011 1017" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>APAF1:AVEN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2878" reactomeId="6805422" position="2562 785" bounds="2521 774 83 22" textPosition="2521 775" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CASP9:CARD</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2928" reactomeId="113592" position="2605 982" bounds="2585 967 40 30" textPosition="2589 971"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="2949" reactomeId="9628212" position="2760 945" bounds="2699 920 123 50" textPosition="2699 921" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>APAF1:ATP:CYCS heptamer:p-T125-CASP9</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2951" reactomeId="29370" position="2681 985" bounds="2665 970 33 31" textPosition="2665 975" /> <org.gk.render.RenderableEntitySet id="2972" reactomeId="6804662" position="2965 971" bounds="2924 960 82 22" textPosition="2924 960"> <Properties> <displayName>Apoptosome</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="2975" reactomeId="6804636" position="3032 1005" bounds="3012 994 41 22" textPosition="3012 994"> <Properties> <displayName>UACA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2976" reactomeId="6804657" position="3010 1099" bounds="2952 1088 117 22" textPosition="2952 1089" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>UACA:apoptosome</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2978" reactomeId="6805816" position="1940 1114" bounds="1918 1103 45 22" textPosition="1918 1103" /> <org.gk.render.RenderableProtein id="2979" reactomeId="6805825" position="2079 1116" bounds="2057 1105 45 22" textPosition="2057 1105"> <Properties> <displayName>SEPT4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2982" reactomeId="9627347" position="2114 700" bounds="2071 689 87 22" textPosition="2073 690" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SEPT4 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2983" reactomeId="9627441" position="2298 698" bounds="2237 686 123 25" textPosition="2242 690" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SEPT4 dimer:XIAP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="3058" reactomeId="1268261" position="2645 1066" bounds="2583 1055 124 22" textPosition="2583 1055"> <Properties> <displayName>p-T,Y MAPK dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="3209" reactomeId="9645669" position="2403 1204" bounds="2335 1193 137 23" textPosition="2376 1194"> <Properties> <displayName>p14ARF</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="3210" reactomeId="9645693" position="2144 1381" bounds="2095 1370 98 22" textPosition="2095 1371" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="3240" reactomeId="9645711" position="1616 1382" bounds="1567 1371 98 22" textPosition="1567 1372" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p14ARF:C1QBP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="3241" reactomeId="9645765" position="2075 1236" bounds="2014 1222 123 28" textPosition="2016 1229" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>C1QBP homotrimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="3372" reactomeId="9692432" position="1203 285" bounds="1142 275 123 21" textPosition="1150 275" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>BCL2 antagonists</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="3373" reactomeId="9692353" position="1133 404" bounds="1083 387 101 34" textPosition="1096 386" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>BCL2:BCL2 antagonists</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="3374" reactomeId="9710347" position="2025 753" bounds="1975 735 101 36" textPosition="1975 736" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GSDMD(1-275):cardiolipin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="3375" reactomeId="9710344" position="2002 709" bounds="1944 698 117 22" textPosition="1946 699" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GSDME:cardiolipin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="3674" reactomeId="5620971" position="2184 756" bounds="2141 736 87 41" textPosition="2147 742"> <Properties> <displayName>Pyroptosis</displayName> </Properties> </org.gk.render.ProcessNode> </Nodes> <Edges> <org.gk.render.RenderableReaction id="79" reactomeId="139898" points="567 1058, 602 1079, 625 1017" position="602 1079" lineWidth="1.0"> <Inputs> <Input id="80" /> </Inputs> <Outputs> <Output id="81" /> </Outputs> <Catalysts> <Catalyst id="2366" points="602 1128" /> </Catalysts> <Properties> <displayName>Caspase-8 activates BID by cleavage</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="83" reactomeId="139893" points="538 1030, 500 1003, 586 1003" position="500 1003" lineWidth="1.0"> <Inputs> <Input id="80" /> </Inputs> <Outputs> <Output id="81" /> </Outputs> <Catalysts> <Catalyst id="84" points="432 1003" /> </Catalysts> <Properties> <displayName>Granzyme-B activates BID by cleavage</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="85" reactomeId="141367" points="675 1003, 700 1003, 696 1305" position="700 1003" lineWidth="1.0"> <Inputs> <Input id="81" /> </Inputs> <Outputs> <Output id="86" /> </Outputs> <Catalysts> <Catalyst id="87" points="738 974" /> </Catalysts> <Properties> <displayName>Myristoylation of tBID by NMT1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="88" reactomeId="139920" points="756 1316, 778 1316, 867 1315" position="778 1316" lineWidth="1.0"> <Inputs> <Input id="86" /> </Inputs> <Outputs> <Output id="89" /> </Outputs> <Properties> <displayName>Translocation of tBID to mitochondria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="124" reactomeId="139899" points="557 1618, 558 1617, 604 1617" position="558 1617" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2394" points="640 1544" /> <Input id="2372" points="515 1580" /> </Inputs> <Outputs> <Output id="126" /> </Outputs> <Properties> <displayName>Sequestration of BAD protein by 14-3-3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="127" reactomeId="139906" points="758 1617, 778 1617, 777 1557" position="778 1617" lineWidth="1.0"> <Inputs> <Input id="126" points="736 1617" /> <Input id="2407" points="750 1597" /> </Inputs> <Outputs> <Output id="121" points="777 1513" /> <Output id="2408" points="808 1554" /> <Output id="2394" points="697 1544" /> </Outputs> <Catalysts> <Catalyst id="128" points="778 1665" /> </Catalysts> <Properties> <displayName>Activation of BAD by calcineurin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="129" reactomeId="139905" points="798 1498, 833 1497, 887 1497" position="833 1497" lineWidth="1.0"> <Inputs> <Input id="121" /> </Inputs> <Outputs> <Output id="130" /> </Outputs> <Properties> <displayName>Translocation of activated BAD protein to mitochondria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="131" reactomeId="139897" points="868 1451, 866 1409, 866 1353" position="866 1409" lineWidth="1.0"> <Inputs> <Input id="130" points="897 1483" /> <Input id="132" points="900 1447" /> </Inputs> <Outputs> <Output id="89" points="909 1329" /> <Output id="133" points="903 1355" /> </Outputs> <Properties> <displayName>BAD displaces tBID from BCL-2 sequestration</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="134" reactomeId="140214" points="437 485, 563 534, 729 518" position="563 534" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2470" /> </Inputs> <Outputs> <Output id="135" /> </Outputs> <Activators> <Activator id="2475" points="566 573" /> </Activators> <Properties> <displayName>TP53 stimulates PMAIP1 (NOXA) expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="136" reactomeId="140217" points="437 485, 559 501, 729 513" position="559 501" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2470" /> </Inputs> <Outputs> <Output id="135" /> </Outputs> <Activators> <Activator id="2487" points="559 476" /> </Activators> <Properties> <displayName>Transactivation of PMAIP1 (NOXA) by E2F1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="138" reactomeId="140216" points="770 530, 829 586, 881 586" position="829 586" lineWidth="1.0"> <Inputs> <Input id="135" /> </Inputs> <Outputs> <Output id="139" /> </Outputs> <Properties> <displayName>Translocation of PMAIP1 (NOXA) to mitochondria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="140" reactomeId="139913" points="394 309, 549 304, 731 320" position="549 304" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2461" /> </Inputs> <Outputs> <Output id="141" /> </Outputs> <Activators> <Activator id="2465" points="554 283" /> </Activators> <Properties> <displayName>TP53 stimulates BBC3 (PUMA) expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="142" reactomeId="140221" points="394 309, 551 341, 731 323" position="551 341" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2461" /> </Inputs> <Outputs> <Output id="141" /> </Outputs> <Activators> <Activator id="2483" points="551 378" /> </Activators> <Properties> <displayName>Transactivation of BBC3 (PUMA) by E2F1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="143" reactomeId="139914" points="762 336, 836 429, 883 429" position="836 429" lineWidth="1.0"> <Inputs> <Input id="141" /> </Inputs> <Outputs> <Output id="144" /> </Outputs> <Properties> <displayName>Translocation of BBC3 (PUMA) protein to mitochondria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="201" reactomeId="139918" points="178 752, 178 731, 177 684" position="178 731" lineWidth="1.0"> <Inputs> <Input id="2812" points="203 753" /> <Input id="202" points="178 773" /> </Inputs> <Outputs> <Output id="2428" points="202 684" /> <Output id="2813" points="196 668" /> <Output id="204" points="177 637" /> </Outputs> <Catalysts> <Catalyst id="2370" points="296 818, 295 730" /> </Catalysts> <Properties> <displayName>Phosphorylation of BIM by JNK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="291" reactomeId="139919" points="283 685, 403 685, 874 679" position="403 685" lineWidth="1.0"> <Inputs> <Input id="2428" /> </Inputs> <Outputs> <Output id="2431" /> </Outputs> <Properties> <displayName>Translocation of BIM to mitochondria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="321" reactomeId="139908" points="180 918, 180 945, 178 976" position="180 945" lineWidth="1.0"> <Inputs> <Input id="2792" points="204 914" /> <Input id="322" points="180 891" /> </Inputs> <Outputs> <Output id="324" points="179 1060" /> <Output id="2427" points="217 976" /> <Output id="2793" points="208 1016" /> </Outputs> <Catalysts> <Catalyst id="2370" points="297 846, 297 943" /> </Catalysts> <Properties> <displayName>Phosphorylation of DLC2 by MAPK8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="381" reactomeId="139909" points="309 977, 336 977, 338 718, 879 715" position="336 977" lineWidth="1.0"> <Inputs> <Input id="2427" /> </Inputs> <Outputs> <Output id="2432" /> </Outputs> <Properties> <displayName>Translocation of BMF to mitochondria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1952" reactomeId="508163" points="1319 409, 1318 409, 1367 409" position="1318 409" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1953" points="1304 454" /> <Input id="1954" points="1276 409" /> </Inputs> <Outputs> <Output id="1955" /> </Outputs> <Properties> <displayName>BH3-only proteins associate with and inactivate anti-apoptotic BCL-2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1956" reactomeId="508162" points="1682 404, 1683 403, 1639 404" position="1683 403" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2352" points="1753 402" /> <Input id="1958" points="1682 462" /> </Inputs> <Outputs> <Output id="1959" /> </Outputs> <Properties> <displayName>BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2016" reactomeId="139917" points="528 826, 636 826, 636 870" position="636 826" lineWidth="1.0"> <Inputs> <Input id="2017" /> </Inputs> <Outputs> <Output id="2018" points="683 870" /> <Output id="81" points="630 989" /> </Outputs> <Properties> <displayName>tBID activates BAX protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2019" reactomeId="114264" points="781 871, 802 871, 895 873" position="802 871" lineWidth="1.0"> <Inputs> <Input id="2018" /> </Inputs> <Outputs> <Output id="2020" /> </Outputs> <Properties> <displayName>Translocation of activated BAX to the mitochondria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2021" reactomeId="114275" points="914 860, 915 799, 916 765" position="915 799" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2020" stoichiometry="2" /> </Inputs> <Outputs> <Output id="2022" /> </Outputs> <Properties> <displayName>Oligomerization of BAX at the mitochondrial membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2051" reactomeId="168849" points="573 934, 574 933, 493 847" position="574 933" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="81" points="620 989" /> <Input id="2052" points="522 937" /> </Inputs> <Outputs> <Output id="2017" /> </Outputs> <Properties> <displayName>tBID binds to inactive BAX protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2053" reactomeId="139895" points="869 1188, 869 1231, 869 1255" position="869 1231" lineWidth="1.0"> <Inputs> <Input id="2054" /> </Inputs> <Outputs> <Output id="89" points="916 1301" /> <Output id="2055" points="915 1253" /> </Outputs> <Properties> <displayName>tBID activates BAK protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2084" reactomeId="114263" points="968 1237, 968 1159, 970 1069, 946 1069" position="968 1159" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2055" stoichiometry="2" /> </Inputs> <Outputs> <Output id="2085" /> </Outputs> <Properties> <displayName>Oligomerization of BAK at the mitochondrial membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2142" reactomeId="168848" points="736 1044, 737 1045, 849 1146" position="737 1045" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="89" points="897 1301, 736 1243" /> <Input id="2143" points="879 985" /> </Inputs> <Outputs> <Output id="2054" /> </Outputs> <Properties> <displayName>tBID binds to inactive BAK protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2144" reactomeId="114284" points="1956 826, 1995 826, 2049 826" position="1995 826" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2145" /> </Inputs> <Outputs> <Output id="2146" /> </Outputs> <Activators> <Activator id="2531" points="1916 600, 1915 799" /> <Activator id="3374" points="2017 774" /> <Activator id="3375" points="1941 712, 1931 713" /> </Activators> <Properties> <displayName>Release of Cytochrome c from mitochondria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2175" reactomeId="114307" points="1975 449, 2002 449, 2035 449" position="2002 449" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2176" /> </Inputs> <Outputs> <Output id="2177" /> </Outputs> <Activators> <Activator id="2531" points="1929 552" /> </Activators> <Properties> <displayName>Release of SMAC (DIABLO) from mitochondria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2178" reactomeId="114254" points="2147 874, 2166 873, 2184 874" position="2166 873" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2814" points="2133 885" /> <Input id="2146" points="2089 841" /> <Input id="2815" points="2094 873" /> </Inputs> <Outputs> <Output id="2816" points="2233 874" /> <Output id="2817" points="2204 889" /> </Outputs> <Properties> <displayName>CYCS binds to APAF1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2181" reactomeId="114256" points="2390 876, 2411 876, 2462 876" position="2411 876" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2816" stoichiometry="7" points="2349 875" /> <Input id="2183" stoichiometry="4" points="2391 796" /> </Inputs> <Outputs> <Output id="2818" /> </Outputs> <Inhibitors> <Inhibitor id="2819" points="2450 827, 2409 854" /> <Inhibitor id="2820" points="2474 927" /> <Inhibitor id="2821" points="2121 957, 2359 957" /> </Inhibitors> <Properties> <displayName>CYCS:APAF1 binds procaspase-9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2185" reactomeId="114259" points="2885 875, 2913 876, 2945 876" position="2913 876" lineWidth="1.0"> <Inputs> <Input id="2822" /> </Inputs> <Outputs> <Output id="2186" points="2965 887" /> <Output id="2187" points="2942 647" /> </Outputs> <Catalysts> <Catalyst id="2822" points="2885 859, 2913 853" /> </Catalysts> <Properties> <displayName>Cleavage of Procaspase‑9 to caspase‑9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2244" reactomeId="114252" points="2367 549, 2397 548, 2426 547" position="2397 548" lineWidth="1.0"> <Inputs> <Input id="2496" points="2347 548" /> <Input id="2497" points="2367 533" /> </Inputs> <Outputs> <Output id="2498" points="2441 556" /> <Output id="2499" points="2426 475" /> </Outputs> <Catalysts> <Catalyst id="2187" points="2879 627, 2409 613, 2409 560" /> </Catalysts> <Inhibitors> <Inhibitor id="2823" points="2228 614, 2391 614, 2391 561" /> </Inhibitors> <Properties> <displayName>Cleavage of Procaspase-3 by the apoptosome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2249" reactomeId="114261" points="2695 526, 2738 526, 2786 527" position="2738 526" lineWidth="1.0"> <Inputs> <Input id="2500" points="2671 526" /> <Input id="2501" points="2695 535" /> </Inputs> <Outputs> <Output id="2252" points="2818 533" /> <Output id="2253" points="2786 487" /> </Outputs> <Catalysts> <Catalyst id="2187" points="2910 612, 2753 543" /> </Catalysts> <Inhibitors> <Inhibitor id="2823" points="2207 629, 2207 644, 2738 643" /> </Inhibitors> <Properties> <displayName>Cleavage of Procaspase-7 by the apoptosome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2310" reactomeId="114306" points="2299 260, 2298 285, 2298 337" position="2298 285" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2824" points="2299 212" /> <Input id="2311" points="2263 260" /> </Inputs> <Outputs> <Output id="2312" /> </Outputs> <Properties> <displayName>SMAC binds XIAP:Caspase-3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2313" reactomeId="114354" points="2385 273, 2414 297, 2443 322" position="2414 297" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2824" points="2312 212" /> <Input id="2314" points="2470 272" /> </Inputs> <Outputs> <Output id="2315" /> </Outputs> <Properties> <displayName>SMAC binds XIAP:Caspase-7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2316" reactomeId="114361" points="2536 199, 2566 199, 2608 199" position="2566 199" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2824" points="2349 198" /> <Input id="2825" points="2528 217" /> </Inputs> <Outputs> <Output id="2318" /> </Outputs> <Properties> <displayName>SMAC binds XIAP within apoptosome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2347" reactomeId="114419" points="2299 379, 2302 418, 2335 420" position="2302 418" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="2312" /> </Inputs> <Outputs> <Output id="2499" points="2402 447" /> <Output id="2826" points="2855 180, 2596 424" /> </Outputs> <Properties> <displayName>Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2349" reactomeId="114392" points="2463 364, 2463 393, 2560 395" position="2463 393" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="2315" /> </Inputs> <Outputs> <Output id="2253" points="2754 459" /> <Output id="2826" points="2852 180" /> </Outputs> <Properties> <displayName>Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2350" reactomeId="114440" points="2675 178, 2675 129, 2944 128" position="2675 129" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="2318" /> </Inputs> <Outputs> <Output id="2187" points="2942 612" /> <Output id="2826" points="2889 152" /> </Outputs> <Properties> <displayName>Dissociation of DIABLO:XIAP from the apoptosome complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2353" reactomeId="114352" points="1036 1337, 1037 1337, 950 1429" position="1037 1337" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="89" points="981 1329" /> <Input id="1954" points="1231 418, 1041 510" /> </Inputs> <Outputs> <Output id="132" /> </Outputs> <Properties> <displayName>Sequestration of tBID by BCL-2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2377" reactomeId="198347" points="560 1501, 505 1502, 504 1524" position="505 1502" lineWidth="1.0"> <Inputs> <Input id="121" points="758 1499" /> <Input id="2378" points="571 1491" /> </Inputs> <Outputs> <Output id="2379" points="469 1525" /> <Output id="2372" points="504 1552" /> </Outputs> <Catalysts> <Catalyst id="2380" points="505 1445" /> </Catalysts> <Properties> <displayName>AKT phosphorylates BAD</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2382" interactionType="Activate" points="394 1426, 456 1427" position="425 1426" lineWidth="2.0"> <Inputs> <Input id="2381" /> </Inputs> <Outputs> <Output id="2380" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.EntitySetAndMemberLink id="2436" points="926 573, 1083 461, 1232 473" position="1083 461" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="139" /> </Inputs> <Outputs> <Output id="1953" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2437" points="927 1490, 1093 1424, 1129 496, 1232 484" position="1111 960" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="130" /> </Inputs> <Outputs> <Output id="1953" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2438" points="929 431, 1232 470" position="1080 450" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="144" /> </Inputs> <Outputs> <Output id="1953" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2439" points="955 669, 990 659, 1092 470, 1232 475" position="1041 564" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2431" /> </Inputs> <Outputs> <Output id="1953" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2440" points="934 713, 1033 705, 1106 477, 1232 477" position="1069 591" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2432" /> </Inputs> <Outputs> <Output id="1953" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2450" points="973 1301, 1166 1258, 1362 590, 1627 510" position="1264 924" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="89" /> </Inputs> <Outputs> <Output id="1958" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="2451" points="1617 484, 1366 479" position="1491 481" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="1958" /> </Inputs> <Outputs> <Output id="1953" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndMemberLink id="2452" points="929 434, 1236 518, 1617 490" position="1236 518" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="144" /> </Inputs> <Outputs> <Output id="1958" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2453" points="927 1493, 1140 1450, 1383 600, 1635 510" position="1261 1025" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="130" /> </Inputs> <Outputs> <Output id="1958" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2454" points="942 583, 1617 493" position="1279 538" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="139" /> </Inputs> <Outputs> <Output id="1958" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2455" points="955 675, 996 671, 1617 502" position="996 671" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2431" /> </Inputs> <Outputs> <Output id="1958" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="2490" reactomeId="4331327" points="412 455, 446 455, 492 455" position="446 455" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="137" points="357 435" /> <Input id="2470" points="437 485" /> </Inputs> <Outputs> <Output id="2487" /> </Outputs> <Properties> <displayName>E2F1 binds PMAIP1 (NOXA) promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2491" reactomeId="4331340" points="434 283, 435 243, 460 237, 498 238" position="460 237" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2505" points="403 273" /> <Input id="2461" points="394 309" /> </Inputs> <Outputs> <Output id="2465" /> </Outputs> <Properties> <displayName>TP53 binds the BBC3 (PUMA) promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2493" reactomeId="4331324" points="410 398, 445 398, 491 398" position="445 398" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="137" points="369 407" /> <Input id="2461" points="394 309" /> </Inputs> <Outputs> <Output id="2483" /> </Outputs> <Properties> <displayName>E2F1 binds BBC3 (PUMA) promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2494" reactomeId="4331331" points="449 562, 478 600, 507 600" position="478 600" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2470" points="437 485" /> <Input id="2506" points="424 584" /> </Inputs> <Outputs> <Output id="2475" /> </Outputs> <Properties> <displayName>TP53 binds the PMAIP1 (NOXA) promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="2532" points="967 742, 1848 587" position="1407 664" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2022" /> </Inputs> <Outputs> <Output id="2531" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2533" points="916 1049, 1878 600" position="1397 824" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2085" /> </Inputs> <Outputs> <Output id="2531" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="2786" reactomeId="6790025" points="463 160, 589 187, 988 251, 996 381" position="589 187" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2787" /> </Inputs> <Outputs> <Output id="2788" /> </Outputs> <Activators> <Activator id="2791" points="589 132" /> </Activators> <Properties> <displayName>Expression of BCL2, BCL2L1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="2789" points="1753 395, 1485 323, 1050 390" position="1485 323" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2352" /> </Inputs> <Outputs> <Output id="2788" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2790" points="1231 398, 1132 343, 1024 381" position="1132 343" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1954" /> </Inputs> <Outputs> <Output id="2788" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="2827" reactomeId="9627106" points="2064 436, 2064 196, 2251 197" position="2064 196" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2177" stoichiometry="2" /> </Inputs> <Outputs> <Output id="2824" /> </Outputs> <Properties> <displayName>SMAC (DIABLO) forms dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2828" reactomeId="9627350" points="2323 164, 2359 164, 2802 165" position="2359 164" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2824" points="2307 184" /> <Input id="2823" stoichiometry="2" points="2186 615, 2144 615, 2141 163" /> </Inputs> <Outputs> <Output id="2826" /> </Outputs> <Properties> <displayName>SMAC (DIABLO) binds XIAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2841" reactomeId="9627104" points="2207 461, 2207 358, 2207 274" position="2207 358" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2499" points="2387 461" /> <Input id="2823" stoichiometry="2" points="2207 601" /> </Inputs> <Outputs> <Output id="2311" /> </Outputs> <Inhibitors> <Inhibitor id="2312" points="2251 358" /> </Inhibitors> <Properties> <displayName>XIAP binds CASP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2846" reactomeId="9627107" points="2525 472, 2525 434, 2525 286" position="2525 434" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2253" points="2746 472" /> <Input id="2823" stoichiometry="2" points="2228 621, 2260 633, 2526 633" /> </Inputs> <Outputs> <Output id="2314" /> </Outputs> <Inhibitors> <Inhibitor id="2824" points="2307 212, 2456 434" /> </Inhibitors> <Properties> <displayName>XIAP binds CASP7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2851" reactomeId="9627078" points="2151 666, 2106 666, 2107 136, 2521 139, 2520 211, 2522 217" position="2106 666" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2823" stoichiometry="2" points="2194 629" /> <Input id="2187" points="2879 643, 2783 667" /> </Inputs> <Outputs> <Output id="2825" /> </Outputs> <Inhibitors> <Inhibitor id="2824" points="2260 212, 2127 246, 2130 608" /> </Inhibitors> <Properties> <displayName>XIAP binds CASP9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2860" reactomeId="9627056" points="2582 876, 2614 876, 2752 874" position="2614 876" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2818" /> </Inputs> <Outputs> <Output id="2822" /> </Outputs> <Properties> <displayName>Procaspase 9 forms dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2873" reactomeId="6804596" points="2522 942, 2523 971, 2523 1004" position="2523 971" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2818" points="2522 898" /> <Input id="2820" points="2509 941" /> </Inputs> <Outputs> <Output id="2874" /> </Outputs> <Properties> <displayName>APAF1:CYCS binds APIP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2875" reactomeId="6805507" points="2051 957, 2052 980, 2051 1013" position="2052 980" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2821" points="2074 957" /> <Input id="2815" points="2052 887" /> </Inputs> <Outputs> <Output id="2876" /> </Outputs> <Properties> <displayName>APAF1 binds AVEN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2877" reactomeId="6805426" points="2463 782, 2487 781, 2518 782" position="2487 781" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2183" points="2441 782" /> <Input id="2819" points="2464 799" /> </Inputs> <Outputs> <Output id="2878" /> </Outputs> <Properties> <displayName>CARD8 binds CASP9(1-416)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2883" reactomeId="9627089" points="2616 945, 2640 946, 2662 946" position="2640 946" lineWidth="1.0"> <Inputs> <Input id="2928" points="2609 964" /> <Input id="2818" points="2546 898" /> </Inputs> <Outputs> <Output id="2949" points="2696 945" /> <Output id="2951" points="2673 967" /> </Outputs> <Catalysts> <Catalyst id="3058" points="2644 1049" /> </Catalysts> <Properties> <displayName>CASP9 is phosphorylated at T125</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2971" reactomeId="6804652" points="3010 1036, 3010 1056, 3010 1085" position="3010 1056" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2972" points="2972 988" /> <Input id="2975" points="3024 1019" /> </Inputs> <Outputs> <Output id="2976" /> </Outputs> <Properties> <displayName>UACA binds apoptosome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="2973" points="3005 623, 3023 622, 3034 970, 3012 970" position="3028 796" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2187" /> </Inputs> <Outputs> <Output id="2972" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2974" points="2847 895, 2947 954" position="2897 924" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2822" /> </Inputs> <Outputs> <Output id="2972" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="2977" reactomeId="6805811" points="1966 1114, 1999 1115, 2054 1115" position="1999 1115" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2978" /> </Inputs> <Outputs> <Output id="2979" /> </Outputs> <Properties> <displayName>Release of SEPT4 from mitochondria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2981" reactomeId="9627369" points="2182 698, 2208 698, 2234 698" position="2208 698" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2982" points="2161 698" /> <Input id="2823" points="2203 629" /> </Inputs> <Outputs> <Output id="2983" /> </Outputs> <Properties> <displayName>SEPT4 binds XIAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3207" reactomeId="9645694" points="2144 1272, 2144 1316, 2144 1367" position="2144 1316" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3209" points="2359 1219" /> <Input id="3241" points="2101 1253" /> </Inputs> <Outputs> <Output id="3210" /> </Outputs> <Properties> <displayName>p14ARF binds C1QBP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3239" reactomeId="9645692" points="2092 1380, 1865 1380, 1668 1381" position="1865 1380" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="3210" /> </Inputs> <Outputs> <Output id="3240" /> </Outputs> <Properties> <displayName>C1QBP promotes translocation of p14ARF to the mitochondrial matrix</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3371" reactomeId="9692376" points="1203 327, 1203 329, 1148 384" position="1203 329" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1954" points="1246 395" /> <Input id="3372" points="1203 302" /> </Inputs> <Outputs> <Output id="3373" /> </Outputs> <Properties> <displayName>BCL2 binds BCL2 antagonists</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="3678" interactionType="Activate" points="2138 741, 2080 721, 2064 718" position="2080 721" lineWidth="2.0"> <Inputs> <Input id="3674" /> </Inputs> <Outputs> <Output id="3375" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="3688" interactionType="Activate" points="2138 754, 2079 753" position="2108 753" lineWidth="2.0"> <Inputs> <Input id="3674" /> </Inputs> <Outputs> <Output id="3374" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of Intrinsic Pathway for Apoptosis and Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function (450953)
