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Details on Person Diagram of Influenza Infection

Class:Id	PathwayDiagram:450901
_displayName	Diagram of Influenza Infection
_timestamp	2026-02-20 06:40:02
created	[InstanceEdit:450899] Gillespie, ME, 2009-12-22
height	2067
modified	[InstanceEdit:1679954] Wu, G, 2011-10-20 [InstanceEdit:1910009] Gillespie, ME, 2011-11-01 [InstanceEdit:1960438] Gillespie, ME, 2011-11-03 [InstanceEdit:5605196] Gillespie, Marc E, 2014-07-04 [InstanceEdit:5606955] Gillespie, Marc E, 2014-07-07 [InstanceEdit:6792739] Matthews, Lisa, 2015-08-26 [InstanceEdit:8855192] Wu, G, 2016-02-02 [InstanceEdit:8856871] Gillespie, Marc E, 2016-02-12 [InstanceEdit:8861980] Gillespie, Marc E, 2016-02-22 [InstanceEdit:8961596] Gillespie, Marc E, 2017-02-02 [InstanceEdit:9006611] Gillespie, Marc E, 2017-05-17 [InstanceEdit:9006612] Gillespie, Marc E, 2017-05-17 [InstanceEdit:9615455] Orlic-Milacic, Marija, 2018-08-07 [InstanceEdit:9634280] Gillespie, Marc E, 2019-01-08 [InstanceEdit:9672970] Gillespie, Marc E, 2020-01-03 [InstanceEdit:9672990] Gillespie, Marc E, 2020-01-03 [InstanceEdit:9672991] Gillespie, Marc E, 2020-01-03 [InstanceEdit:9672992] Gillespie, Marc E, 2020-01-03 [InstanceEdit:9672993] Gillespie, Marc E, 2020-01-03 [InstanceEdit:9672994] Gillespie, Marc E, 2020-01-03 [InstanceEdit:9672997] Gillespie, Marc E, 2020-01-03 [InstanceEdit:9675124] Gillespie, Marc E, 2020-01-31 [InstanceEdit:9677227] Gillespie, Marc E, 2020-02-28 [InstanceEdit:9699029] Matthews, Lisa, 2020-09-09 [InstanceEdit:9757635] D'Eustachio, Peter, 2021-11-03 [InstanceEdit:9758276] D'Eustachio, Peter, 2021-11-09 [InstanceEdit:9836719] Stephan, Ralf, 2023-06-01 [InstanceEdit:9956907] Stephan, Ralf, 2025-06-16 [InstanceEdit:9971131] Shamovsky, Veronica, 2025-11-04 [InstanceEdit:9971184] Shamovsky, Veronica, 2025-11-04 [InstanceEdit:9982877] Shamovsky, Veronica, 2026-02-20
representedPathway	[Pathway:168255] Influenza Infection [Homo sapiens]
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lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>vRNP:M1:NEP:NP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="68" reactomeId="165529" position="1869 1250" bounds="1849 1239 40 22" textPosition="1849 1239"> <Properties> <displayName>XPO1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="69" reactomeId="29372" position="1666 1161" bounds="1644 1148 45 27" textPosition="1657 1150"> <Properties> <displayName>Pi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="70" reactomeId="192667" position="1714 1286" bounds="1672 1268 84 36" textPosition="1672 1268" bgColor="204 255 255" fgColor="0 0 0" lineColor="236 0 0" hideComponents="true"> <Properties> <displayName>vRNP Export Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="71" reactomeId="165538" position="1633 1105" bounds="1593 1087 81 36" textPosition="1593 1087" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" hideComponents="true"> <Properties> <displayName>Crm1:Ran GTPase:GDP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="72" reactomeId="195764" position="2361 552" bounds="2330 541 63 22" textPosition="2330 541"> <Properties> <displayName>Lipid Raft</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableProtein id="73" reactomeId="195782" position="1731 264" bounds="1718 253 26 22" textPosition="1718 253" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" /> <org.gk.render.RenderableComplex id="74" reactomeId="195725" position="2389 474" bounds="2329 451 120 47" textPosition="2334 448" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Glycosylated, palmitylated and folded HA trimer</displayName> </Properties> 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36" textPosition="2165 246" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableComplex id="79" reactomeId="195755" position="2636 268" bounds="2588 229 96 78" textPosition="2588 229" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableComplex id="80" reactomeId="195727" position="2384 696" bounds="2342 685 84 22" textPosition="2342 685" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableComplex id="81" reactomeId="195724" position="2386 626" bounds="2344 608 84 36" textPosition="2344 608" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableProtein id="82" reactomeId="203497" position="2745 1000" bounds="2730 989 31 22" textPosition="2733 989" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0"> <Properties> <displayName>NA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="83" reactomeId="195819" position="2549 470" bounds="2495 451 108 39" textPosition="2494 454" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableComplex id="84" reactomeId="195723" position="2178 470" bounds="2130 431 96 78" textPosition="2130 431" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Glycosylated, palmitylated and folded HA trimer:Lipid Raft Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="85" reactomeId="195787" position="2337 927" bounds="2289 902 96 50" textPosition="2289 902" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Glycosylated and folded HA trimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="86" reactomeId="195797" position="2515 1075" bounds="2473 1064 84 22" textPosition="2473 1064" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>M2 Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="87" reactomeId="195775" position="2343 998" bounds="2301 980 84 36" textPosition="2301 980" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Glycosylated NA Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="88" reactomeId="169073" position="1765 324" bounds="1752 313 26 22" textPosition="1752 313" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" /> <org.gk.render.RenderableComplex id="89" reactomeId="195761" position="2234 696" bounds="2192 678 84 36" textPosition="2192 678" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>palmitylated M2 Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="90" reactomeId="195740" position="2300 570" bounds="2288 559 24 22" textPosition="2288 559"> <Properties> <displayName>NP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="91" reactomeId="195790" position="2800 949" bounds="2784 938 32 22" textPosition="2787 938" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0"> <Properties> <displayName>HA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="92" reactomeId="195815" position="2512 1000" bounds="2470 982 84 36" textPosition="2470 982" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0"> <Properties> <displayName>Glycosylated NA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="93" reactomeId="195906" position="2678 885" bounds="2651 874 55 22" textPosition="2658 874"> <Properties> <displayName>CANX</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="94" reactomeId="195756" position="2728 1073" bounds="2715 1062 26 22" textPosition="2715 1062" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0"> <Properties> <displayName>M2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="95" reactomeId="195766" position="2358 264" bounds="2317 253 83 22" textPosition="2317 253" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>NP:Lipid Raft</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="96" reactomeId="195736" position="2180 629" bounds="2129 604 102 50" textPosition="2129 604" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableComplex id="97" reactomeId="195737" position="2174 545" bounds="2133 534 83 22" textPosition="2133 534" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableComplex id="98" reactomeId="195803" position="2341 858" bounds="2293 833 96 50" textPosition="2293 833" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableComplex id="99" reactomeId="195794" position="2250 823" bounds="2208 812 84 22" textPosition="2208 812" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableComplex id="100" reactomeId="195796" position="2150 799" bounds="2108 781 84 36" textPosition="2108 781" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableCompartment id="101" reactomeId="20699" position="2339 548" bounds="2052 364 575 369" textPosition="2062 696" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>Golgi membrane</displayName> </Properties> <Components> <Component id="72" /> <Component id="74" /> <Component id="80" /> <Component id="81" /> <Component id="83" /> <Component id="84" /> <Component id="89" /> <Component id="90" /> <Component id="96" /> <Component id="97" /> <Component id="197" /> <Component id="200" /> <Component id="201" /> <Component id="202" /> <Component id="204" /> <Component id="194" /> <Component id="207" /> <Component id="194" /> <Component id="207" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="102" reactomeId="12045" position="2446 944" bounds="2038 758 817 372" textPosition="2058 1091" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>endoplasmic reticulum membrane</displayName> </Properties> <Components> <Component id="98" /> <Component id="99" /> <Component id="206" /> <Component id="75" /> <Component id="77" /> <Component id="82" /> <Component id="85" /> <Component id="86" /> <Component id="87" /> <Component id="91" /> <Component id="92" /> <Component id="93" /> <Component id="94" /> <Component id="193" /> <Component id="195" /> <Component id="198" /> <Component id="199" /> <Component id="205" /> <Component id="100" /> <Component id="203" /> <Component id="217" /> <Component id="192" /> <Component id="125" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="103" reactomeId="24337" position="718 1227" bounds="548 773 340 908" textPosition="560 1642" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>endocytic vesicle membrane</displayName> </Properties> <Components> <Component id="6" /> <Component id="9" /> <Component id="163" /> <Component id="165" /> <Component id="166" /> <Component id="7" /> <Component id="8" /> <Component id="10" /> <Component id="11" /> <Component id="12" /> <Component id="13" /> <Component id="14" /> <Component id="16" /> <Component id="164" /> <Component id="167" /> <Component id="168" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="104" reactomeId="195947" position="1866 628" bounds="1818 617 97 22" textPosition="1818 617" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Segment 1 RNP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="105" reactomeId="195752" position="1679 266" bounds="1667 255 24 22" textPosition="1667 255" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" /> <org.gk.render.RenderableComplex id="106" reactomeId="195738" position="1598 263" bounds="1550 231 96 64" textPosition="1550 231" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableComplex id="107" reactomeId="195949" position="1494 606" bounds="1446 595 97 22" textPosition="1446 595" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Segment 8 RNP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="108" reactomeId="195951" position="1682 750" bounds="1634 739 97 22" textPosition="1634 739" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Segment 5 RNP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="109" reactomeId="195925" position="1461 266" bounds="1422 241 79 50" textPosition="1422 241" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Intracellular assembly complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="110" reactomeId="195946" position="1886 540" bounds="1871 529 30 22" textPosition="1871 529" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0"> <Properties> <displayName>PB2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="111" reactomeId="195939" position="1551 657" bounds="1503 646 97 22" textPosition="1503 646" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Segment 7 RNP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="112" reactomeId="195942" position="1781 784" bounds="1733 773 97 22" textPosition="1733 773" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Segment 4 RNP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="113" reactomeId="196496" position="1733 489" bounds="1700 464 66 50" textPosition="1700 464" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>RNP pre-assembly complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="114" reactomeId="192845" position="1984 535" bounds="1954 524 60 22" textPosition="1954 524" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0"> <Properties> <displayName>NEP/NS2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="115" reactomeId="195943" position="1616 708" bounds="1568 697 97 22" textPosition="1568 697" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Segment 6 RNP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="116" reactomeId="195728" position="1853 265" bounds="1802 247 102 36" textPosition="1802 247" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Gycosylated NA Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="117" reactomeId="195948" position="1999 473" bounds="1988 462 23 22" textPosition="1988 462" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" /> <org.gk.render.RenderableComplex id="118" reactomeId="195952" position="1848 738" bounds="1800 727 97 22" textPosition="1800 727" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Segment 3 RNP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="119" reactomeId="195950" position="1893 687" bounds="1845 676 97 22" textPosition="1845 676" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Segment 2 RNP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="120" reactomeId="195940" position="2003 429" bounds="1988 418 30 22" textPosition="1988 418" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" /> <org.gk.render.RenderableComplex id="121" reactomeId="195945" position="1271 260" bounds="1219 235 104 50" textPosition="1219 235" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableEntity id="122" reactomeId="169703" position="863 266" bounds="741 245 245 43" textPosition="750 248" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>Host Derived Lipid Bilayer Membrane Rich In Sphingolipids And Cholesterol</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableProtein id="123" reactomeId="195915" position="1190 206" bounds="1172 195 36 22" textPosition="1177 195" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" /> <org.gk.render.RenderableComplex id="124" reactomeId="195941" position="1271 111" bounds="1221 93 100 36" textPosition="1231 93" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true" /> <org.gk.render.RenderableComplex id="125" reactomeId="2168084" position="2041 784" bounds="1993 773 96 22" textPosition="1999 773" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Viral Proteins</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="126" reactomeId="157689" position="2356 1217" bounds="2302 1199 109 36" textPosition="2309 1199" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="127" reactomeId="6792605" position="1656 1534" bounds="1615 1523 82 22" textPosition="1629 1523"> <Properties> <displayName>HSPA1A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="128" reactomeId="192720" position="2723 1707" bounds="2686 1689 74 36" textPosition="2686 1689" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableComplex id="129" reactomeId="192682" position="2357 1665" bounds="2338 1654 38 22" textPosition="2338 1654" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>cRNP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="130" reactomeId="192720" position="2380 1767" bounds="2343 1749 74 36" textPosition="2343 1749" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableComplex id="131" reactomeId="192720" position="2199 1574" bounds="2162 1556 74 36" textPosition="2162 1556" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableComplex id="132" reactomeId="192720" position="2058 1731" bounds="2021 1713 74 36" textPosition="2021 1713" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>Viral Polymerase</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="133" reactomeId="193302" position="2223 1413" bounds="2178 1388 90 50" textPosition="2178 1388" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableComplex id="134" reactomeId="193302" position="2470 1605" bounds="2425 1580 90 50" textPosition="2425 1580" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>vRNA (Genomic):NP Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="135" reactomeId="188832" position="2567 1703" bounds="2555 1692 24 22" textPosition="2555 1692" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" isForDisease="true" /> <org.gk.render.RenderableProtein id="136" reactomeId="188832" position="2463 1911" bounds="2451 1900 24 22" textPosition="2451 1900" bgColor="204 255 204" fgColor="0 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hideComponents="true"> <Properties> <displayName>ISGylated NS1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="142" reactomeId="1176073" position="1525 1466" bounds="1493 1454 64 25" textPosition="1497 1455"> <Properties> <displayName>Importin</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="143" reactomeId="1176060" position="1338 1118" bounds="1305 1103 66 31" textPosition="1310 1107" /> <org.gk.render.RenderableComplex id="144" reactomeId="169143" position="1501 1061" bounds="1467 1043 68 36" textPosition="1480 1043" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>NS1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="145" reactomeId="169145" position="1424 1467" bounds="1381 1449 87 36" textPosition="1386 1449" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NS1 Homodimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="146" reactomeId="1176067" position="1438 1339" bounds="1385 1319 107 40" textPosition="1386 1323" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>NS1 homodimer:Importin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="147" reactomeId="169075" position="1553 879" bounds="1501 859 105 40" textPosition="1501 863" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>NS1:viral dsRNA Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="148" reactomeId="6790580" position="1631 1041" bounds="1573 1023 117 36" textPosition="1572 1023" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>Influenza A dsRNA intermediate form</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableComplex id="149" reactomeId="169142" position="1427 900" bounds="1364 882 126 36" textPosition="1373 882" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NS1 Homodimer:PKR Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="150" reactomeId="168699" position="1397 1067" bounds="1365 1055 65 24" textPosition="1369 1056"> <Properties> <displayName>EIF2AK2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="151" reactomeId="169102" position="1352 1716" bounds="1301 1696 103 40" textPosition="1317 1700" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NS1:PAB II Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="152" reactomeId="72008" position="1301 1537" bounds="1273 1526 57 22" textPosition="1274 1526"> <Properties> <displayName>PABPN1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="153" reactomeId="169104" position="1517 1533" bounds="1493 1522 49 22" textPosition="1496 1522"> <Properties> <displayName>CPSF4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="154" reactomeId="169074" position="1477 1719" bounds="1429 1700 97 38" textPosition="1444 1702" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CPSF:NS1 Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="155" reactomeId="6791037" position="1106 262" bounds="1026 245 161 35" textPosition="1032 244" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Large latent complex of TGFB1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="156" reactomeId="170852" position="1107 140" bounds="1059 128 97 24" textPosition="1060 130" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Dimeric TGFB1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="157" reactomeId="49745" position="1188 603" bounds="1156 592 65 22" textPosition="1158 592"> <Properties> <displayName>SLC25A6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="158" reactomeId="5146789" position="1200 560" bounds="1172 549 57 22" textPosition="1175 549" /> <org.gk.render.RenderableComplex id="159" reactomeId="169235" position="1068 607" bounds="1024 589 89 36" textPosition="1024 589" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PB1-F2: ANT 3 Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="160" reactomeId="17906" position="1131 665" bounds="1006 532 251 266" textPosition="1010 762" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>mitochondrial outer membrane</displayName> </Properties> <Components> <Component id="161" /> <Component id="158" /> <Component id="225" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="161" reactomeId="70616" position="1129 671" bounds="1046 593 166 156" textPosition="1049 695" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>mitochondrial inner membrane</displayName> </Properties> <Components> <Component id="157" /> <Component id="159" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="244" reactomeId="9677228" position="2729 1819" bounds="2695 1808 69 22" textPosition="2696 1808" bgColor="204 255 255" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>NP:PARP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="245" reactomeId="9757634" position="2294 1828" bounds="2262 1813 64 31" textPosition="2278 1817"> <Properties> <displayName>NTP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="247" reactomeId="9757634" position="2581 1886" bounds="2549 1871 64 31" textPosition="2565 1875" /> <org.gk.render.ProcessNode id="248" reactomeId="9833482" position="1425 805" bounds="1371 779 108 53" textPosition="1372 783"> <Properties> <displayName>PKR-mediated signaling</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableProtein id="253" reactomeId="1031698" position="1282 1036" bounds="1262 1025 40 23" textPosition="1262 1025"> <Properties> <displayName>GBP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="254" reactomeId="9955201" position="1302 899" bounds="1269 888 67 23" textPosition="1269 889" bgColor="204 255 255" isForDisease="true" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>GBP1:NS1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="259" reactomeId="9953170" position="1300 835" bounds="1237 809 127 53" textPosition="1248 813"> <Properties> <displayName>GBP-mediated host defense</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableProtein id="265" reactomeId="5218901" position="1144 1011" bounds="1125 1000 39 23" textPosition="1125 1000"> <Properties> <displayName>MLKL</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="266" reactomeId="9686346" position="1176 880" bounds="1143 869 66 23" textPosition="1143 870" bgColor="204 255 255" isForDisease="true" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>NS1:MLKL</displayName> </Properties> </org.gk.render.RenderableComplex> </Nodes> <Edges> <org.gk.render.RenderableReaction id="162" reactomeId="168272" points="429 408, 443 472, 501 542" position="443 472" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="2" points="505 289" /> <Input id="1" points="350 345" /> </Inputs> <Outputs> <Output id="3" /> </Outputs> <Properties> <displayName>Binding of the influenza virion to the host cell</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="163" reactomeId="168285" points="527 598, 554 709, 561 762" position="554 709" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="3" /> </Inputs> <Outputs> <Output id="5" points="537 761" /> <Output id="6" points="620 805" /> </Outputs> <Activators> <Activator id="4" points="503 679" /> </Activators> <Properties> <displayName>Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="164" reactomeId="168306" points="649 1137, 648 1164, 648 1185" position="648 1164" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="7" /> </Inputs> <Outputs> <Output id="8" /> </Outputs> <Properties> <displayName>Concerted hemagglutinin pore formation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="165" reactomeId="168312" points="647 971, 647 1007, 648 1039" position="647 1007" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="9" /> </Inputs> <Outputs> <Output id="7" /> </Outputs> <Properties> <displayName>Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="166" reactomeId="168324" points="644 848, 645 875, 646 901" position="645 875" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="6" /> </Inputs> <Outputs> <Output id="9" /> </Outputs> <Properties> <displayName>Conformation change in hemagglutinin freeing the fusion peptide of HA2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="167" reactomeId="168299" points="697 1518, 707 1530, 737 1527" position="707 1530" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="13" /> </Inputs> <Outputs> <Output id="10" stoichiometry="165" points="648 1597" /> <Output id="15" points="804 1692" /> <Output id="14" points="767 1515" /> <Output id="16" stoichiometry="3000" points="620 1534" /> <Output id="11" points="777 1563" /> </Outputs> <Properties> <displayName>Ribonucleoprotein release from M1 proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="168" reactomeId="168313" points="667 1324, 643 1377, 646 1391" position="643 1377" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="12" points="702 1312" /> <Input id="8" points="660 1297" /> </Inputs> <Outputs> <Output id="13" /> </Outputs> <Catalysts> <Catalyst id="8" points="646 1297" /> </Catalysts> <Properties> <displayName>Virion-associated M2 protein mediated ion infusion</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="169" reactomeId="168297" points="814 1769, 815 1799, 816 1848" position="815 1799" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="19" points="757 1769" /> <Input id="15" points="814 1748" /> </Inputs> <Outputs> <Output id="24" /> </Outputs> <Properties> <displayName>Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="170" reactomeId="168310" points="1306 1874, 1335 1874, 1359 1873" position="1335 1874" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="17" points="1387 1904" /> <Output id="22" points="1428 1871" /> <Output id="25" points="1372 1849" /> </Outputs> <Properties> <displayName>Release of the RNP into the host cell nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="171" reactomeId="168337" points="1082 1875, 1133 1874, 1213 1874" position="1133 1874" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="23" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> <Activators> <Activator id="18" points="1133 1815" /> </Activators> <Properties> <displayName>Docking and transport of the RNP:Karyopherin complex through the nuclear pore</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="172" reactomeId="168317" points="916 1876, 945 1875, 989 1876" position="945 1875" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="24" points="866 1876" /> <Input id="20" points="931 1843" /> </Inputs> <Outputs> <Output id="23" /> </Outputs> <Properties> <displayName>Recruitment of Karyopherin Beta to form a Trimeric Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="173" reactomeId="192912" points="2018 1427, 2102 1423, 2175 1416" position="2102 1423" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="29" stoichiometry="24" points="2019 1502" /> <Input id="28" points="1979 1394" /> </Inputs> <Outputs> <Output id="133" /> </Outputs> <Properties> <displayName>NP binds vRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="174" reactomeId="192830" points="1946 1699, 1970 1701, 2018 1718" position="1970 1701" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="30" points="1911 1723" /> <Input id="31" points="1914 1699" /> <Input id="33" points="1911 1672" /> </Inputs> <Outputs> <Output id="132" /> </Outputs> <Activators> <Activator id="32" points="1956 1761" /> <Activator id="34" points="1978 1619" /> </Activators> <Properties> <displayName>Viral Polymerase Assembly</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="175" reactomeId="192925" points="2629 1277, 2628 1250, 2627 1213" position="2628 1250" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="36" points="2665 1317" /> <Input id="46" points="2598 1303" /> </Inputs> <Outputs> <Output id="45" points="2680 1178" /> <Output id="41" points="2584 1180" /> </Outputs> <Catalysts> <Catalyst id="126" points="2414 1223" /> </Catalysts> <Properties> <displayName>Export of Spliced Viral mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="176" reactomeId="168301" points="2252 1726, 2274 1619, 2288 1558" position="2274 1619" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="245" points="2287 1810" /> <Input id="49" points="2198 1825" /> </Inputs> <Outputs> <Output id="133" points="2234 1441" /> <Output id="47" points="2352 1367" /> <Output id="131" points="2239 1567" /> </Outputs> <Catalysts> <Catalyst id="131" points="2229 1595" /> </Catalysts> <Properties> <displayName>Elongation, Polyadenylation and Termination</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="177" reactomeId="168280" points="2138 1696, 2136 1729, 2137 1769" position="2136 1729" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="43" /> </Inputs> <Outputs> <Output id="49" points="2170 1825" /> <Output id="48" points="2099 1808" /> </Outputs> <Catalysts> <Catalyst id="132" points="2098 1730" /> </Catalysts> <Properties> <displayName>Priming and Initiation of Transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="178" reactomeId="168326" points="2173 1508, 2119 1576, 2134 1640" position="2119 1576" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="39" points="2151 1499" /> <Input id="131" points="2191 1553" /> <Input id="133" points="2209 1441" /> </Inputs> <Outputs> <Output id="43" /> </Outputs> <Activators> <Activator id="29" points="2035 1523" /> <Activator id="40" points="1997 1551" /> </Activators> <Properties> <displayName>Assembly of an Active Transcription Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="179" reactomeId="192781" points="2636 1426, 2636 1394, 2635 1369" position="2636 1394" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="44" points="2676 1462" /> <Input id="38" points="2602 1464" /> </Inputs> <Outputs> <Output id="36" points="2660 1345" /> <Output id="46" points="2594 1331" /> </Outputs> <Properties> <displayName>Viral mRNA Splicing (M, NS segments)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="180" reactomeId="192627" points="2318 1317, 2101 1221, 2019 1186" position="2101 1221" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="47" /> </Inputs> <Outputs> <Output id="37" /> </Outputs> <Catalysts> <Catalyst id="126" points="2299 1217" /> </Catalysts> <Properties> <displayName>Viral mRNA Export</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="181" reactomeId="192624" points="2498 1703, 2445 1700, 2400 1691" position="2445 1700" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="51" points="2482 1791" /> <Input id="135" stoichiometry="24" points="2552 1703" /> <Input id="247" points="2573 1868" /> </Inputs> <Outputs> <Output id="129" points="2375 1679" /> <Output id="130" points="2384 1746" /> <Output id="134" points="2449 1633" /> </Outputs> <Catalysts> <Catalyst id="130" points="2420 1765, 2447 1765" /> </Catalysts> <Properties> <displayName>cRNA Extension</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="182" reactomeId="192832" points="2386 1889, 2420 1862, 2455 1836" position="2420 1862" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="245" points="2317 1847" /> <Input id="35" points="2252 1934" /> <Input id="130" points="2380 1788" /> </Inputs> <Outputs> <Output id="51" /> </Outputs> <Catalysts> <Catalyst id="130" points="2387 1788" /> </Catalysts> <Activators> <Activator id="136" points="2453 1897" /> </Activators> <Properties> <displayName>Initiation of cRNA Synthesis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="183" reactomeId="192851" points="2632 1832, 2628 1773, 2624 1692" position="2628 1773" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="53" points="2738 1861" /> <Input id="135" stoichiometry="24" points="2572 1717" /> <Input id="247" points="2595 1868" /> </Inputs> <Outputs> <Output id="52" points="2625 1618" /> <Output id="50" points="2777 1609" /> <Output id="134" points="2514 1633" /> <Output id="128" points="2683 1701" /> </Outputs> <Catalysts> <Catalyst id="128" points="2715 1728, 2695 1772" /> </Catalysts> <Properties> <displayName>vRNA Extension</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="184" reactomeId="192916" points="2797 1708, 2798 1776, 2793 1852" position="2798 1776" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="50" points="2798 1614" /> <Input id="128" points="2763 1707" /> </Inputs> <Outputs> <Output id="53" /> </Outputs> <Catalysts> <Catalyst id="128" points="2729 1728, 2745 1773" /> </Catalysts> <Activators> <Activator id="244" points="2746 1805" /> </Activators> <Properties> <displayName>Initiation of vRNA Synthesis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="185" reactomeId="192704" points="1752 1019, 1752 965, 1754 859" position="1752 965" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="54" points="1802 1040" /> <Input id="58" points="1752 1104" /> </Inputs> <Outputs> <Output id="57" /> </Outputs> <Catalysts> <Catalyst id="55" points="1777 964" /> </Catalysts> <Properties> <displayName>Synthesis of PB1-F2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="186" reactomeId="192841" points="1919 1023, 1920 967, 1924 937" position="1920 967" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="54" points="1895 1037" /> <Input id="37" points="1992 1152" /> </Inputs> <Outputs> <Output id="125" points="2032 798" /> <Output id="59" points="1924 867" /> </Outputs> <Catalysts> <Catalyst id="55" points="1871 964" /> </Catalysts> <Activators> <Activator id="61" points="1966 935" /> <Activator id="56" points="1962 965" /> <Activator id="60" points="1963 993" /> </Activators> <Properties> <displayName>Viral Protein Synthesis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="187" reactomeId="192677" points="1760 1696, 1753 1661, 1751 1639" position="1753 1661" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="35" points="2156 1947, 1913 1936" /> <Input id="33" stoichiometry="8" points="1882 1666" /> <Input id="31" stoichiometry="8" points="1878 1699" /> <Input id="30" stoichiometry="8" points="1879 1732" /> </Inputs> <Outputs> <Output id="64" /> </Outputs> <Activators> <Activator id="139" points="1719 1695" /> </Activators> <Properties> <displayName>Newly synthesized vRNP for export</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="188" reactomeId="192746" points="1750 1562, 1750 1533, 1747 1499" position="1750 1533" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="66" stoichiometry="8" points="1682 1589" /> <Input id="64" points="1750 1594" /> </Inputs> <Outputs> <Output id="62" /> </Outputs> <Inhibitors> <Inhibitor id="127" points="1700 1533" /> </Inhibitors> <Properties> <displayName>Binding of M1 to vRNP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="189" reactomeId="168893" points="1843 1390, 1845 1360, 1848 1337" position="1845 1360" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="62" points="1765 1457" /> <Input id="63" stoichiometry="8" points="1883 1424" /> </Inputs> <Outputs> <Output id="65" /> </Outputs> <Properties> <displayName>Binding of NEP/NS2 to vRNP:M1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="190" reactomeId="168857" points="1830 1285, 1792 1285, 1759 1285" position="1792 1285" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="68" points="1856 1264" /> <Input id="65" points="1844 1309" /> </Inputs> <Outputs> <Output id="70" /> </Outputs> <Properties> <displayName>Binding of vRNP:M1:NEP complex to CRM1 export receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="191" reactomeId="168880" points="1609 1257, 1609 1218, 1608 1193" position="1609 1218" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="138" points="1588 1292" /> <Input id="70" points="1669 1274" /> </Inputs> <Outputs> <Output id="67" points="1561 1164" /> <Output id="69" points="1641 1173" /> <Output id="71" points="1627 1126" /> </Outputs> <Activators> <Activator id="137" points="1567 1215" /> </Activators> <Properties> <displayName>vRNP Export through the nuclear pore</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="192" reactomeId="195733" points="2741 1149, 2740 1128, 2730 1087" position="2740 1128" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Outputs> <Output id="94" /> </Outputs> <Properties> <displayName>M2 protein synthesis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="193" reactomeId="188544" points="2712 1073, 2627 1074, 2560 1074" position="2627 1074" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="94" stoichiometry="4" /> </Inputs> <Outputs> <Output id="86" /> </Outputs> <Properties> <displayName>Assembly of M2 tetramers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="194" reactomeId="195739" points="2339 694, 2302 694, 2279 694" position="2302 694" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="80" /> </Inputs> <Outputs> <Output id="89" /> </Outputs> <Properties> <displayName>Palmitoylation of cysteine residues on M2 in the cis-golgi network</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="195" reactomeId="168875" points="2459 946, 2414 946, 2388 938" position="2414 946" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="77" stoichiometry="3" /> </Inputs> <Outputs> <Output id="85" /> </Outputs> <Properties> <displayName>Trimerization of HA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="196" reactomeId="168894" points="1768 310, 1775 289, 1747 271" position="1775 289" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="88" /> </Inputs> <Outputs> <Output id="73" /> </Outputs> <Properties> <displayName>Accumulation of M1 at the inner leaflet of the lipid bilayer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="197" reactomeId="195730" points="2076 517, 2077 438, 2259 349" position="2077 438" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="89" points="2189 695, 2082 693" /> <Input id="84" points="2127 492" /> <Input id="96" points="2156 601" /> <Input id="97" points="2135 531" /> </Inputs> <Outputs> <Output id="76" points="2434 282" /> <Output id="78" points="2218 285" /> <Output id="95" points="2345 278" /> <Output id="79" points="2585 278" /> </Outputs> <Properties> <displayName>Transport of processed viral proteins to the cell membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="198" reactomeId="169847" points="2467 999, 2432 999, 2388 998" position="2432 999" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="92" stoichiometry="4" /> </Inputs> <Outputs> <Output id="87" /> </Outputs> <Properties> <displayName>Assembly of NA tetramers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="199" reactomeId="169919" points="2727 999, 2635 998, 2557 999" position="2635 998" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="82" /> </Inputs> <Outputs> <Output id="92" /> </Outputs> <Properties> <displayName>Glycosylation of NA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="200" reactomeId="168882" points="2272 544, 2251 544, 2219 544" position="2251 544" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="72" points="2327 549" /> <Input id="90" points="2288 556" /> </Inputs> <Outputs> <Output id="97" /> </Outputs> <Properties> <displayName>Association of NP into rafts</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="201" reactomeId="168862" points="2287 471, 2257 472, 2229 471" position="2257 472" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="72" points="2350 538" /> <Input id="74" points="2326 472" /> </Inputs> <Outputs> <Output id="84" /> </Outputs> <Properties> <displayName>Association of HA into rafts</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="202" reactomeId="168858" points="2492 472, 2475 473, 2452 473" position="2475 473" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="83" /> </Inputs> <Outputs> <Output id="74" /> </Outputs> <Properties> <displayName>Palmitoylation of cysteine residues on HA in the cis-Golgi network</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="203" reactomeId="195734" points="2804 1152, 2797 1127, 2749 1014" position="2797 1127" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Outputs> <Output id="82" /> </Outputs> <Properties> <displayName>Neuraminidase (NA) synthesis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="204" reactomeId="195726" points="2287 627, 2257 628, 2234 628" position="2257 628" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="72" points="2350 566" /> <Input id="81" points="2341 626" /> </Inputs> <Outputs> <Output id="96" /> </Outputs> <Properties> <displayName>Association of NA into rafts</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="205" reactomeId="169921" points="2781 948, 2660 947, 2557 947" position="2660 947" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="91" /> </Inputs> <Outputs> <Output id="77" /> </Outputs> <Activators> <Activator id="93" points="2674 899" /> <Activator id="75" points="2698 931" /> </Activators> <Properties> <displayName>Glycosylation and Folding of HA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="206" reactomeId="168869" points="2245 955, 2247 908, 2243 861" position="2247 908" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="85" points="2286 941" /> <Input id="86" points="2470 1073, 2307 1070" /> <Input id="87" points="2301 977" /> </Inputs> <Outputs> <Output id="98" points="2290 859" /> <Output id="99" points="2247 837" /> <Output id="100" points="2177 820" /> </Outputs> <Properties> <displayName>Budding of vesicle with the HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum into the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="207" reactomeId="168871" points="2373 772, 2538 771, 2536 628, 2486 629" position="2536 628" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="98" points="2350 830" /> <Input id="99" points="2276 809" /> <Input id="100" points="2195 793" /> </Inputs> <Outputs> <Output id="80" points="2400 682" /> <Output id="81" points="2431 627" /> <Output id="83" points="2541 493" /> </Outputs> <Properties> <displayName>Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="208" reactomeId="168895" points="1714 629, 1721 567, 1729 517" position="1721 567" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="111" points="1603 648" /> <Input id="112" points="1776 770" /> <Input id="104" points="1815 628" /> <Input id="115" points="1629 694" /> <Input id="107" points="1546 611" /> <Input id="108" points="1684 736" /> <Input id="118" points="1834 724" /> <Input id="119" points="1859 673" /> </Inputs> <Outputs> <Output id="113" /> </Outputs> <Properties> <displayName>RNP association</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="209" reactomeId="195926" points="1754 400, 1673 391, 1456 378, 1459 294" position="1456 378" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="114" stoichiometry="157" points="1965 521" /> <Input id="78" stoichiometry="60" points="2162 276" /> <Input id="113" points="1738 461" /> <Input id="106" stoichiometry="500" points="1634 298" /> <Input id="105" stoichiometry="976" points="1685 280" /> <Input id="116" stoichiometry="100" points="1839 286" /> <Input id="117" stoichiometry="37" points="1985 469" /> <Input id="120" stoichiometry="37" points="1985 427" /> <Input id="110" stoichiometry="37" points="1875 526" /> <Input id="88" stoichiometry="2992" points="1763 338" /> </Inputs> <Outputs> <Output id="109" /> </Outputs> <Properties> <displayName>Association with M1 at cell membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="210" reactomeId="168860" points="1358 345, 1321 309, 1296 288" position="1321 309" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="122" points="921 291, 1004 318" /> <Input id="109" points="1428 294" /> <Input id="2" points="529 289, 583 341" /> </Inputs> <Outputs> <Output id="121" /> </Outputs> <Properties> <displayName>Membrane fusion</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="211" reactomeId="168870" points="1271 232, 1271 204, 1271 132" position="1271 204" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="121" /> </Inputs> <Outputs> <Output id="124" /> </Outputs> <Catalysts> <Catalyst id="123" points="1211 205" /> </Catalysts> <Properties> <displayName>Neuraminidase enzymatic release from sialic acid</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="212" points="2549 1464, 2388 1367" position="2468 1415" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="38" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="213" points="2519 1322, 2417 1335" position="2468 1328" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="46" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="214" points="2647 1456, 2407 1367" position="2527 1411" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="44" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="215" points="2631 1332, 2417 1340" position="2524 1336" lineWidth="1.0" lineColor="255 0 0"> <Inputs> <Input id="36" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="216" points="1807 1128, 1956 1161" position="1881 1144" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="58" /> </Inputs> <Outputs> <Output id="37" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="217" reactomeId="168884" points="2819 1152, 2833 1127, 2802 963" position="2833 1127" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Outputs> <Output id="91" /> </Outputs> <Properties> <displayName>Hemagglutinin (HA) protein synthesis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="218" reactomeId="1176059" points="1429 1181, 1431 1222, 1436 1316" position="1431 1222" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="143" points="1360 1140" /> <Input id="144" points="1490 1082" /> </Inputs> <Outputs> <Output id="146" /> </Outputs> <Catalysts> <Catalyst id="137" points="1466 1218" /> </Catalysts> <Inhibitors> <Inhibitor id="141" points="1339 1193" /> </Inhibitors> <Properties> <displayName>Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="219" reactomeId="6791035" points="1439 1362, 1442 1387, 1442 1416" position="1442 1387" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="146" /> </Inputs> <Outputs> <Output id="142" points="1504 1448" /> <Output id="145" points="1430 1446" /> </Outputs> <Properties> <displayName>Release of NS1 homodimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="220" reactomeId="168891" points="1554 996, 1553 949, 1553 902" position="1553 949" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="148" points="1600 1020" /> <Input id="144" points="1515 1040" /> </Inputs> <Outputs> <Output id="147" /> </Outputs> <Properties> <displayName>Binding of NS1 to dsRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="221" reactomeId="168896" points="1428 1003, 1428 967, 1427 921" position="1428 967" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="150" points="1402 1052" /> <Input id="144" points="1478 1040" /> </Inputs> <Outputs> <Output id="149" /> </Outputs> <Properties> <displayName>NS1 binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="222" reactomeId="168859" points="1474 1576, 1478 1630, 1477 1697" position="1478 1630" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="153" points="1506 1547" /> <Input id="145" points="1432 1488" /> </Inputs> <Outputs> <Output id="154" /> </Outputs> <Properties> <displayName>Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="223" reactomeId="168883" points="1349 1568, 1351 1636, 1351 1693" position="1351 1636" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="152" points="1318 1551" /> <Input id="145" points="1410 1488" /> </Inputs> <Outputs> <Output id="151" /> </Outputs> <Properties> <displayName>Binding of NS1 to poly(A)-binding protein II (PABII)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="224" reactomeId="168865" points="1106 242, 1106 207, 1106 155" position="1106 207" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="155" /> </Inputs> <Outputs> <Output id="156" /> </Outputs> <Catalysts> <Catalyst id="123" points="1169 206" /> </Catalysts> <Properties> <displayName>NA activation of TGF-beta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="225" reactomeId="168878" points="1146 565, 1073 564, 1070 586" position="1073 564" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="157" points="1175 589" /> <Input id="158" points="1169 562" /> </Inputs> <Outputs> <Output id="159" /> </Outputs> <Properties> <displayName>PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="251" interactionType="Activate" points="1426 879, 1425 835" position="1425 857" lineWidth="2.0"> <Inputs> <Input id="149" /> </Inputs> <Outputs> <Output id="248" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="252" reactomeId="9955152" points="1303 977, 1303 941, 1302 914" position="1303 941" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="253" points="1286 1022" /> <Input id="144" points="1464 1046" /> </Inputs> <Outputs> <Output id="254" /> </Outputs> <Properties> <displayName>NS1 binds GBP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="263" interactionType="Inhibit" points="1301 885, 1300 865" position="1300 875" lineWidth="2.0"> <Inputs> <Input id="254" /> </Inputs> <Outputs> <Output id="259" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="264" reactomeId="9686343" points="1175 982, 1176 946, 1176 895" position="1176 946" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="265" points="1156 997" /> <Input id="144" points="1464 1052" /> </Inputs> <Outputs> <Output id="266" /> </Outputs> <Properties> <displayName>NS1 binds MLKL</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Influenza Infection (450901)