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Details on Person hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2

Class:Id	BlackBoxEvent:450827
_displayName	hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2
_doRelease	TRUE
_timestamp	2024-07-16 19:50:11
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity	[CatalystActivity:450826] protein serine/threonine kinase activity of hp-IRAK1:Pellino, IRAK4:Pellino [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450821] Jupe, S, 2009-12-17
edited	[InstanceEdit:744683] Jupe, S, 2010-05-17
input	[DefinedSet:451413] hp-IRAK1:Pellino, IRAK4:Pellino [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:450812] Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4 [LiteratureReference:450804] Characterization of Pellino2, a substrate of IRAK1 and IRAK4
modified	[InstanceEdit:451421] Jupe, S, 2010-01-05 [InstanceEdit:451558] Jupe, S, 2010-01-05 [InstanceEdit:744684] Jupe, S, 2010-05-17 [InstanceEdit:8948068] Jupe, Steve, 2016-11-10 [InstanceEdit:9020703] Jupe, Steve, 2017-09-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
name	hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2
output	[DefinedSet:451425] hp-IRAK1:p-Pellino, IRAK4:p-Pellino [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
releaseDate	2010-06-15
reviewed	[InstanceEdit:744680] Pinteaux, E, 2010-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105639] R-HSA-450827.5
summation	[Summation:450808] IRAK1 and 4 can phosphorylate Pellino-1 and -2 and probably ...
(hasEvent)	[Pathway:9020702] Interleukin-1 signaling [Homo sapiens]
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No pathways have been reviewed or authored by hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2 (450827)