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Details on Person The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1

Class:IdLiteratureReference:450692
_displayNameThe IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1
_timestamp2009-12-17 11:05:04
author[Person:450689] Ordureau, A
[Person:169200] Smith, H
[Person:450691] Windheim, M
[Person:434107] Peggie, M
[Person:450688] Carrick, E
[Person:76772] Morrice, N
[Person:433958] Cohen, P
created[InstanceEdit:450687] Jupe, S, 2009-12-17
journalBiochem J
modified[InstanceEdit:450693] Jupe, S, 2009-12-17
pages43-52
pubMedIdentifier17997719
titleThe IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1
volume409
year2008
(literatureReference)[Summation:451689] Interleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL...
[Summation:940396] Both IRAK1 and IRAK4 were shown to phosphorylate Pellino iso...
[Summation:940417] Pellino isoforms -1, 2 and 3 have been shown to interact wit...
[Summation:975757] Pellino proteins have been implicated as mediators in mammal...
[Reaction:450690] hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 [Homo sapiens]
[Reaction:451418] Pellino ubiquitinates IRAK1 [Homo sapiens]
[Reaction:937034] IRAK1 phosphorylates Pellino [Homo sapiens]
[Reaction:937050] Pellino ubiquitinates hp-IRAK1 [Homo sapiens]
[Reaction:975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
[Homo sapiens]

[Reaction:975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation [Homo sapiens]
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No pathways have been reviewed or authored by The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1 (450692)