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Details on Person hp-IRAK1,hp-IRAK4 bind Pellino1,2,3

Class:Id	Reaction:450690
_displayName	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3
_doRelease	TRUE
_timestamp	2017-09-11 14:13:02
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450687] Jupe, S, 2009-12-17
edited	[InstanceEdit:744683] Jupe, S, 2010-05-17
input	[DefinedSet:450810] p-2S,S376,T,T209,T387-IRAK1, IRAK4 [cytosol] [Homo sapiens] [DefinedSet:450814] Pellino 1,2,3 [cytosol] [Homo sapiens] [DefinedSet:450814] Pellino 1,2,3 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:450692] The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1 [LiteratureReference:450818] Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex [LiteratureReference:450804] Characterization of Pellino2, a substrate of IRAK1 and IRAK4 [LiteratureReference:450820] Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner [LiteratureReference:450816] Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases
modified	[InstanceEdit:450693] Jupe, S, 2009-12-17 [InstanceEdit:450821] Jupe, S, 2009-12-17 [InstanceEdit:451421] Jupe, S, 2010-01-05 [InstanceEdit:622266] Jupe, S, 2010-04-22 [InstanceEdit:744684] Jupe, S, 2010-05-17 [InstanceEdit:8948068] Jupe, Steve, 2016-11-10 [InstanceEdit:9020703] Jupe, Steve, 2017-09-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3
output	[DefinedSet:451413] hp-IRAK1:Pellino, IRAK4:Pellino [cytosol] [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:744680] Pinteaux, E, 2010-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104113] R-HSA-450690.4
summation	[Summation:450811] IRAK1 and 4 interact with Pellino-1 (Jiang et al. 2003), 2 (...
(hasEvent)	[Pathway:9020702] Interleukin-1 signaling [Homo sapiens]
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No pathways have been reviewed or authored by hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (450690)