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Details on Person HuR:mRNA complex translocates from the nucleus to the cytosol

Class:Id	BlackBoxEvent:450595
_displayName	HuR:mRNA complex translocates from the nucleus to the cytosol
_doRelease	TRUE
_timestamp	2014-02-05 02:40:34
authored	[InstanceEdit:451187] May, B, 2009-12-29
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:450588] May, B, 2009-12-16
edited	[InstanceEdit:451187] May, B, 2009-12-29
input	[Complex:450537] HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:450478] Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression [LiteratureReference:451254] Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs [LiteratureReference:517721] Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression
modified	[InstanceEdit:451138] May, B, 2009-12-30 [InstanceEdit:451255] May, B, 2009-12-30 [InstanceEdit:517669] May, B, 2010-02-19 [InstanceEdit:766133] May, B, 2010-05-21 [InstanceEdit:847705] May, B, 2010-05-30 [InstanceEdit:882028] May, B, 2010-06-29 [InstanceEdit:927717] May, B, 2010-08-06 [InstanceEdit:5251727] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HuR:mRNA complex translocates from the nucleus to the cytosol
output	[EntityWithAccessionedSequence:450619] p-T243-TNFSF13 [cytosol] [Homo sapiens] [DefinedSet:517713] HuR:mRNA Complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:450387] HuR binds the CRM1 nuclear export machinery [Homo sapiens] [Reaction:450494] HuR binds mRNAs in the nucleus [Homo sapiens] [Reaction:517674] p-S158,221-HuR binds mRNA [Homo sapiens] [Reaction:517705] p-S318,221-HuR binds mRNA [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:882027] Wilusz, J, 2010-06-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104090] R-HSA-450595.2
summation	[Summation:451156] mRNA bound to HuR is exported from the nucleus by a mechanis...
(hasEvent)	[Pathway:450520] HuR (ELAVL1) binds and stabilizes mRNA [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:450389] Expression of Proto-oncogene c-fos [Homo sapiens] [BlackBoxEvent:450470] Expression of PTGS2 (COX-2) [Homo sapiens] [BlackBoxEvent:450473] Expression of CD83 Antigen [Homo sapiens] [BlackBoxEvent:517640] Expression of Cyclin D1 [Homo sapiens] [BlackBoxEvent:517752] Expression of Cyclin A2 (Cyclin A) [Homo sapiens]
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No pathways have been reviewed or authored by HuR:mRNA complex translocates from the nucleus to the cytosol (450595)