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Details on Person KSRP binds AU-rich element in 3' UTR of mRNA

Class:Id	Reaction:450592
_displayName	KSRP binds AU-rich element in 3' UTR of mRNA
_doRelease	TRUE
_timestamp	2023-12-10 08:25:46
authored	[InstanceEdit:451187] May, B, 2009-12-29
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450588] May, B, 2009-12-16
edited	[InstanceEdit:451187] May, B, 2009-12-29
input	[EntityWithAccessionedSequence:450485] KSRP [cytosol] [Homo sapiens] [OtherEntity:450386] mRNA Transcript Targeted by KSRP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:451125] The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets [LiteratureReference:517775] Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes [LiteratureReference:517706] Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements [LiteratureReference:517774] IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR [LiteratureReference:9856076] Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling
modified	[InstanceEdit:451138] May, B, 2009-12-30 [InstanceEdit:517669] May, B, 2010-02-19 [InstanceEdit:766133] May, B, 2010-05-21 [InstanceEdit:789692] D'Eustachio, P, 2010-05-23 [InstanceEdit:847705] May, B, 2010-05-30 [InstanceEdit:882028] May, B, 2010-06-29 [InstanceEdit:927717] May, B, 2010-08-06 [InstanceEdit:5251727] May, B, 2014-02-05 [InstanceEdit:6792722] May, Bruce, 2015-08-26 [InstanceEdit:8864140] May, Bruce, 2016-03-12 [InstanceEdit:8865034] May, Bruce, 2016-03-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9856082] May, Bruce, 2023-12-10
name	KSRP binds AU-rich element in 3' UTR of mRNA
output	[Complex:450608] KSRP:mRNA Complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:75098] mRNP complex dissociates from cytosolic face of NPC [Homo sapiens] [BlackBoxEvent:75097] Transport of the export-competent mRNP complex through the NPC [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:882027] Wilusz, J, 2010-06-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105263] R-HSA-450592.5
summation	[Summation:451221] KSRP (KHSRP) binds AU-rich regions of target RNAs via its fo...
(hasEvent)	[Pathway:450604] KSRP (KHSRP) binds and destabilizes mRNA [Homo sapiens]
(precedingEvent)	[Reaction:450422] KSRP recruits RNA degradation activities [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9864031] Update Tracker - [Reaction:450592] KSRP binds AU-rich element in 3' UTR of mRNA - v88:[add_removeLiteratureReference, modifyText]
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