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Details on Person PKCdelta phosphorylates HuR

Class:IdReaction:450533
_displayNamePKCdelta phosphorylates HuR
_doReleaseTRUE
_timestamp2014-02-05 02:41:42
authored[InstanceEdit:451187] May, B, 2009-12-29
catalystActivity[CatalystActivity:450388] diacylglycerol-dependent, calcium-independent serine/threonine kinase activity of PRKCD(1-676) [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9644035] protein kinase C activity of PRKCD(1-676) [nucleoplasm] Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:450588] May, B, 2009-12-16
edited[InstanceEdit:451187] May, B, 2009-12-29
input[EntityWithAccessionedSequence:450601] ELAVL1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:450594] Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
modified[InstanceEdit:451138] May, B, 2009-12-30
[InstanceEdit:766133] May, B, 2010-05-21
[InstanceEdit:847705] May, B, 2010-05-30
[InstanceEdit:882028] May, B, 2010-06-29
[InstanceEdit:927717] May, B, 2010-08-06
[InstanceEdit:5251727] May, B, 2014-02-05
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePKCdelta phosphorylates HuR
output[EntityWithAccessionedSequence:450532] p-S221,S318-ELAVL1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
releaseDate2010-09-21
reviewed[InstanceEdit:882027] Wilusz, J, 2010-06-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105164] R-HSA-450533.3
summation[Summation:451196] Protein kinase C delta (PKCdelta) phosphorylates HuR (ELAVL1...
(hasEvent)[Pathway:450520] HuR (ELAVL1) binds and stabilizes mRNA [Homo sapiens]
(precedingEvent)[Reaction:517705] p-S318,221-HuR binds mRNA [Homo sapiens]
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