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Details on Person HuR binds mRNAs in the nucleus

Class:Id	Reaction:450494
_displayName	HuR binds mRNAs in the nucleus
_doRelease	TRUE
_timestamp	2016-03-19 07:24:44
authored	[InstanceEdit:451187] May, B, 2009-12-29
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:450588] May, B, 2009-12-16
edited	[InstanceEdit:451187] May, B, 2009-12-29
input	[OtherEntity:450613] mRNA Transcript Targeted by HuR with Unknown Phosphorylation [nucleoplasm] [EntityWithAccessionedSequence:450601] ELAVL1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:451168] Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences [LiteratureReference:451098] Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element [LiteratureReference:451189] Identification of a target RNA motif for RNA-binding protein HuR [LiteratureReference:451110] Protein ligands to HuR modulate its interaction with target mRNAs in vivo [LiteratureReference:451206] A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR
modified	[InstanceEdit:451138] May, B, 2009-12-30 [InstanceEdit:517669] May, B, 2010-02-19 [InstanceEdit:766133] May, B, 2010-05-21 [InstanceEdit:789692] D'Eustachio, P, 2010-05-23 [InstanceEdit:847705] May, B, 2010-05-30 [InstanceEdit:882028] May, B, 2010-06-29 [InstanceEdit:927717] May, B, 2010-08-06 [InstanceEdit:5251727] May, B, 2014-02-05 [InstanceEdit:6792722] May, Bruce, 2015-08-26 [InstanceEdit:8865034] May, Bruce, 2016-03-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HuR binds mRNAs in the nucleus
output	[Complex:450395] HuR with Unknown Phosphorylation: mRNA Complex [nucleoplasm] [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:882027] Wilusz, J, 2010-06-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104633] R-HSA-450494.4
summation	[Summation:451170] HuR binds AU-rich elements of mRNAs. Bound HuR can form olig...
(hasEvent)	[Pathway:450520] HuR (ELAVL1) binds and stabilizes mRNA [Homo sapiens]
(precedingEvent)	[Reaction:450387] HuR binds the CRM1 nuclear export machinery [Homo sapiens]
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No pathways have been reviewed or authored by HuR binds mRNAs in the nucleus (450494)