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Details on Person Protein Kinase B/Akt phosphorylates BRF1

Class:Id	Reaction:450490
_displayName	Protein Kinase B/Akt phosphorylates BRF1
_doRelease	TRUE
_timestamp	2014-02-05 02:41:49
authored	[InstanceEdit:451187] May, B, 2009-12-29
catalystActivity	[CatalystActivity:450501] protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643421] protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol] BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450588] May, B, 2009-12-16
edited	[InstanceEdit:451187] May, B, 2009-12-29
input	[Complex:450589] BRF1:mRNA Complex [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:450409] BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites [LiteratureReference:450413] The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B [LiteratureReference:450565] Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover
modified	[InstanceEdit:451138] May, B, 2009-12-30 [InstanceEdit:766133] May, B, 2010-05-21 [InstanceEdit:847705] May, B, 2010-05-30 [InstanceEdit:882028] May, B, 2010-06-29 [InstanceEdit:927717] May, B, 2010-08-06 [InstanceEdit:5251727] May, B, 2014-02-05 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Protein Kinase B/Akt phosphorylates BRF1
output	[Complex:450378] Phosphorylated BRF1 (Ser92, Ser203):mRNA Complex [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:450517] Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA [Homo sapiens] [Reaction:75098] mRNP complex dissociates from cytosolic face of NPC [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:882027] Wilusz, J, 2010-06-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105689] R-HSA-450490.3
summation	[Summation:450509] BRF1 is phosphorylated at Serine92 and Serine203 by Protein ...
(hasEvent)	[Pathway:450385] Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA [Homo sapiens]
(precedingEvent)	[Reaction:450406] p-S92,203-BRF1 binds 14-3-3 [Homo sapiens]
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