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Details on Person MK2 phosphorylates BRF1

Class:IdReaction:450474
_displayNameMK2 phosphorylates BRF1
_doReleaseTRUE
_timestamp2014-02-05 02:41:07
authored[InstanceEdit:451187] May, B, 2009-12-29
catalystActivity[CatalystActivity:429015] protein serine/threonine kinase activity of p-S272,T222,T334-MAPKAPK2 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:450588] May, B, 2009-12-16
edited[InstanceEdit:451187] May, B, 2009-12-29
input[Complex:450589] BRF1:mRNA Complex [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:450621] The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2
modified[InstanceEdit:451138] May, B, 2009-12-30
[InstanceEdit:517669] May, B, 2010-02-19
[InstanceEdit:766133] May, B, 2010-05-21
[InstanceEdit:789692] D'Eustachio, P, 2010-05-23
[InstanceEdit:847705] May, B, 2010-05-30
[InstanceEdit:882028] May, B, 2010-06-29
[InstanceEdit:927717] May, B, 2010-08-06
[InstanceEdit:5251727] May, B, 2014-02-05
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMK2 phosphorylates BRF1
output[Complex:450502] Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA Complex [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2010-09-21
reviewed[InstanceEdit:882027] Wilusz, J, 2010-06-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105481] R-HSA-450474.2
summation[Summation:451108] MAPK-activated protein kinase 2 (MK2) phosphorylates BRF1 at...
(hasEvent)[Pathway:450385] Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA [Homo sapiens]
(precedingEvent)[Reaction:482788] p-S54,92,203-BRF1 binds 14-3-3 [Homo sapiens]
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