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Details on Person p-S92,203-BRF1 binds 14-3-3

Class:Id	Reaction:450406
_displayName	p-S92,203-BRF1 binds 14-3-3
_doRelease	TRUE
_timestamp	2014-02-05 02:42:54
authored	[InstanceEdit:451187] May, B, 2009-12-29
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450588] May, B, 2009-12-16
edited	[InstanceEdit:451187] May, B, 2009-12-29
input	[EntityWithAccessionedSequence:48888] YWHAB [cytosol] [Homo sapiens] [Complex:450378] Phosphorylated BRF1 (Ser92, Ser203):mRNA Complex [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:450409] BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites [LiteratureReference:450413] The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B
modified	[InstanceEdit:451138] May, B, 2009-12-30 [InstanceEdit:482789] May, B, 2010-01-28 [InstanceEdit:766133] May, B, 2010-05-21 [InstanceEdit:789692] D'Eustachio, P, 2010-05-23 [InstanceEdit:847705] May, B, 2010-05-30 [InstanceEdit:882028] May, B, 2010-06-29 [InstanceEdit:927717] May, B, 2010-08-06 [InstanceEdit:5251727] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-S92,203-BRF1 binds 14-3-3
output	[Complex:450585] Phosphorylated BRF1 (Ser92, Ser203):mRNA:14-3-3 Complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:450490] Protein Kinase B/Akt phosphorylates BRF1 [Homo sapiens] [Reaction:450517] Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:882027] Wilusz, J, 2010-06-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104194] R-HSA-450406.2
summation	[Summation:451230] Phosphorylated BRF1 interacts with 14-3-3, becomes localized...
(hasEvent)	[Pathway:450385] Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA [Homo sapiens]
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No pathways have been reviewed or authored by p-S92,203-BRF1 binds 14-3-3 (450406)