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Details on Person Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation

Class:Id	Polymerisation:450358
_displayName	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
_doRelease	TRUE
_timestamp	2016-11-08 12:45:19
authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
catalystActivity	[CatalystActivity:450295] ubiquitin-protein transferase activity of K63-linked polyUb TRAF6 complexes [endosome membrane]
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
input	[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains
modified	[InstanceEdit:452128] Shamovsky, V, 2010-01-15 [InstanceEdit:500474] Shamovsky, V, 2010-02-04 [InstanceEdit:532471] Shamovsky, V, 2010-02-28 [InstanceEdit:532681] Gillespie, ME, 2010-03-02 [InstanceEdit:975191] Shamovsky, V, 2010-09-22 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:2248848] Shamovsky, V, 2012-05-15 [InstanceEdit:8947979] Shamovsky, Veronica, 2016-11-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
output	[Polymer:450152] K63polyUb [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane [Homo sapiens] [Reaction:975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments [Homo sapiens] [BlackBoxEvent:936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex [Homo sapiens] [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 [Homo sapiens]
releaseDate	2010-12-14
requiredInputComponent	[EntityWithAccessionedSequence:174100] UBE2E1 [cytosol] [Homo sapiens] [Complex:202463] UBE2N:UBE2V1 [cytosol] [Homo sapiens]
reviewed	[InstanceEdit:532638] Gillespie, ME, 2010-03-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104294] R-HSA-450358.3
summation	[Summation:450260] Polyubiquitinated TRAF6 (as E3 ubiquitin ligase) generates f...
(hasEvent)	[Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex [Homo sapiens] [Pathway:975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation [Homo sapiens]
(inferredFrom)	[BlackBoxEvent:433936] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 [Gallus gallus] [BlackBoxEvent:573294] Activated TRAF6 synthesizes free K63 linked pUb chains [Gallus gallus]
(precedingEvent)	[Reaction:975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790120] Update Tracker - [Polymerisation:450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - v35:[modifyText]
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