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Details on Person Activated human JNKs migrate to nucleoplasm

Class:Id	Reaction:450348
_displayName	Activated human JNKs migrate to nucleoplasm
_doRelease	TRUE
_timestamp	2013-08-23 21:19:05
authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
input	[DefinedSet:450226] p-MAPK8,9,10 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:500486] Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK [LiteratureReference:500491] Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP) [LiteratureReference:208214] A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion.
modified	[InstanceEdit:500490] Shamovsky, V, 2010-02-04 [InstanceEdit:532471] Shamovsky, V, 2010-02-28 [InstanceEdit:532636] Gillespie, ME, 2010-03-02 [InstanceEdit:975771] Shamovsky, V, 2010-10-04 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated human JNKs migrate to nucleoplasm
output	[DefinedSet:450253] p-MAPK8,9,10 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:168162] Phosphorylation of human JNKs by activated MKK4/MKK7 [Homo sapiens] [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 [Homo sapiens] [Reaction:2730868] Phosphorylation of MEK7 by MEKK1 [Homo sapiens] [BlackBoxEvent:8980352] TAK1:TAB2:TAB3 complex binds K63-polyUb-TRAF6 [Homo sapiens]
releaseDate	2010-12-14
requiredInputComponent	[Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] [Homo sapiens]
reviewed	[InstanceEdit:532466] Gillespie, ME, 2010-02-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105842] R-HSA-450348.2
summation	[Summation:500492] c-Jun NH2 terminal kinase (JNK) plays a role in conveying si...
(hasEvent)	[Pathway:450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 [Homo sapiens] [Pathway:2559580] Oxidative Stress Induced Senescence [Homo sapiens] [Pathway:2871796] FCERI mediated MAPK activation [Homo sapiens]
(inferredFrom)	[Reaction:437995] Activated JNK migrates to the nucleoplasm [Gallus gallus]
(precedingEvent)	[Reaction:168053] Phosphorylated MAPKs phosphorylate ATF-2 [Homo sapiens] [Reaction:168136] Activated JNKs phosphorylate c-JUN [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790036] Update Tracker - [Reaction:450348] Activated human JNKs migrate to nucleoplasm - v35:[modifyText]
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