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Details on Person activated human TAK1 phosphorylates MKK3/MKK6

Class:Id	Reaction:450346
_displayName	activated human TAK1 phosphorylates MKK3/MKK6
_doRelease	TRUE
_timestamp	2011-11-23 11:08:12
authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
catalystActivity	[CatalystActivity:177696] protein serine/threonine kinase activity of Activated TAK complexes [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [DefinedSet:167916] MAP2K3,MAP2K6 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses [LiteratureReference:438028] Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction [LiteratureReference:437996] Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes [LiteratureReference:442893] MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
modified	[InstanceEdit:453115] Shamovsky, V, 2010-01-18 [InstanceEdit:500581] Shamovsky, V, 2010-02-04 [InstanceEdit:532471] Shamovsky, V, 2010-02-28 [InstanceEdit:532636] Gillespie, ME, 2010-03-02 [InstanceEdit:847076] Shamovsky, V, 2010-05-28 [InstanceEdit:937119] Shamovsky, V, 2010-08-25 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1014300] Shamovsky, V, 2010-11-15 [InstanceEdit:1564975] Shamovsky, V, 2011-09-06 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	activated human TAK1 phosphorylates MKK3/MKK6
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [DefinedSet:167984] p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex [Homo sapiens] [Reaction:177692] Activation of recruited TAK1 within the activated TLR3 complex [Homo sapiens] [Reaction:936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 [Homo sapiens] [Reaction:936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex [Homo sapiens] [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex [Homo sapiens] [Reaction:936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:532466] Gillespie, ME, 2010-02-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104714] R-HSA-450346.2
summation	[Summation:450298] Human MKK3 (MAP2K4) and MKK6 (MAP2K6) are two closely relate...
(hasEvent)	[Pathway:450302] activated TAK1 mediates p38 MAPK activation [Homo sapiens]
(inferredFrom)	[Reaction:437984] Phosphorylation of MKK3/MKK6 by activated TAK1 [Gallus gallus]
(precedingEvent)	[Reaction:450296] Phosphorylated MKK3/MKK6 migrates to nucleus [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779837] Update Tracker - [Reaction:450346] activated human TAK1 phosphorylates MKK3/MKK6 - v64:[modifyText] [_UpdateTracker:9789256] Update Tracker - [Reaction:450346] activated human TAK1 phosphorylates MKK3/MKK6 - v38:[addLiteratureReference] [_UpdateTracker:9790096] Update Tracker - [Reaction:450346] activated human TAK1 phosphorylates MKK3/MKK6 - v35:[modifyText]
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