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Details on Person Phosphorylated MKK3/MKK6 migrates to nucleus

Class:Id	Reaction:450296
_displayName	Phosphorylated MKK3/MKK6 migrates to nucleus
_doRelease	TRUE
_timestamp	2017-02-22 17:24:50
authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
input	[DefinedSet:167984] p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:442922] Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2 [LiteratureReference:442901] Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
modified	[InstanceEdit:500585] Shamovsky, V, 2010-02-04 [InstanceEdit:532471] Shamovsky, V, 2010-02-28 [InstanceEdit:532636] Gillespie, ME, 2010-03-02 [InstanceEdit:975771] Shamovsky, V, 2010-10-04 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1018394] Shamovsky, V, 2010-11-16 [InstanceEdit:3779420] Orlic-Milacic, M, 2013-06-27 [InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:8979205] Orlic-Milacic, Marija, 2017-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated MKK3/MKK6 migrates to nucleus
output	[DefinedSet:450343] p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:450346] activated human TAK1 phosphorylates MKK3/MKK6 [Homo sapiens] [Reaction:847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex [Homo sapiens] [Reaction:936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 [Homo sapiens] [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex [Homo sapiens] [Reaction:3228469] MAP3K5 phosphorylates MKK3 and MKK6 [Homo sapiens] [Reaction:3225851] ROS oxidize thioredoxin and activate MAP3K5 [Homo sapiens]
releaseDate	2010-12-14
requiredInputComponent	[Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] [Homo sapiens]
reviewed	[InstanceEdit:532466] Gillespie, ME, 2010-02-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104083] R-HSA-450296.3
summation	[Summation:444070] The p38 activators MKK3 (MAP2K3) and MKK6 (MAP2K6) were pres...
(hasEvent)	[Pathway:450302] activated TAK1 mediates p38 MAPK activation [Homo sapiens] [Pathway:2559580] Oxidative Stress Induced Senescence [Homo sapiens]
(inferredFrom)	[Reaction:442938] activated MAPK3/MAPK6 migrates to nucleus [Gallus gallus]
(precedingEvent)	[Reaction:450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 [Homo sapiens] [Reaction:3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 [Homo sapiens] [Reaction:8877691] MAP2K6 phosphorylates PIP4K2B [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780108] Update Tracker - [Reaction:450296] Phosphorylated MKK3/MKK6 migrates to nucleus - v64:[modifyText]
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