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Details on Person Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex

Class:Id	BlackBoxEvent:450259
_displayName	Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex
_doRelease	TRUE
_timestamp	2017-12-01 23:33:55
authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
input	[Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:202511] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
modified	[InstanceEdit:500474] Shamovsky, V, 2010-02-04 [InstanceEdit:532471] Shamovsky, V, 2010-02-28 [InstanceEdit:532638] Gillespie, ME, 2010-03-02 [InstanceEdit:532723] Caudy, M, 2010-03-02 [InstanceEdit:2457719] Shamovsky, V, 2012-08-28 [InstanceEdit:5255454] D'Eustachio, Peter, 2014-02-06 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8979781] Shamovsky, Veronica, 2017-02-27 [InstanceEdit:9014312] Shamovsky, Veronica, 2017-07-28 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex
output	[Complex:450309] viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:177694] Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 [Homo sapiens] [Reaction:168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) [Homo sapiens]
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2010-12-14
requiredInputComponent	[EntityWithAccessionedSequence:174100] UBE2E1 [cytosol] [Homo sapiens] [Complex:202463] UBE2N:UBE2V1 [cytosol] [Homo sapiens]
reviewed	[InstanceEdit:532637] Gillespie, ME, 2010-03-02 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8907589] R-HSA-450259.3
summation	[Summation:450304] TRAF6 possesses ubiquitin ligase activity and undergoes K-63...
(hasEvent)	[Pathway:9014325] TICAM1,TRAF6-dependent induction of TAK1 complex [Homo sapiens]
(inferredFrom)	[BlackBoxEvent:433981] Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 [Gallus gallus]
(precedingEvent)	[Polymerisation:9628444] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation [Homo sapiens]
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No pathways have been reviewed or authored by Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex (450259)