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Details on Person Active p38 MAPK phosphorylates MAPKAPK2 or 3

Class:IdReaction:450222
_displayNameActive p38 MAPK phosphorylates MAPKAPK2 or 3
_doReleaseTRUE
_timestamp2013-08-23 21:19:05
authored[InstanceEdit:450323] Shamovsky, V, 2009-12-16
catalystActivity[CatalystActivity:450303] protein serine/threonine kinase activity of p-p38 MAPK: MAPKAPK2,3 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:450323] Shamovsky, V, 2009-12-16
edited[InstanceEdit:532463] Shamovsky, V, 2010-02-27
input[Complex:450213] p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
literatureReference[LiteratureReference:442930] Catalysis and function of the p38 alpha.MK2a signaling complex
[LiteratureReference:442929] Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
[LiteratureReference:187736] Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2
[LiteratureReference:442952] Molecular basis of MAPK-activated protein kinase 2:p38 assembly
[LiteratureReference:3779425] Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase
[LiteratureReference:3779435] 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region
[LiteratureReference:3779424] A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
modified[InstanceEdit:500511] Shamovsky, V, 2010-02-04
[InstanceEdit:525804] Shamovsky, V, 2010-02-22
[InstanceEdit:532471] Shamovsky, V, 2010-02-28
[InstanceEdit:532636] Gillespie, ME, 2010-03-02
[InstanceEdit:1008271] Shamovsky, V, 2010-11-10
[InstanceEdit:3779428] Orlic-Milacic, M, 2013-06-27
[InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActive p38 MAPK phosphorylates MAPKAPK2 or 3
output[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[Complex:450254] p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2010-12-14
reviewed[InstanceEdit:532466] Gillespie, ME, 2010-02-27
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104877] R-HSA-450222.2
summation[Summation:444067] Human p38 MAPK alpha forms a complex with MK2 even when the ...
(hasEvent)[Pathway:450302] activated TAK1 mediates p38 MAPK activation [Homo sapiens]
[Pathway:2559580] Oxidative Stress Induced Senescence [Homo sapiens]
(inferredFrom)[Reaction:442913] Active p38 MAPK phosphorylates MAPKAPK2 or 3 [Gallus gallus]
(precedingEvent)[Reaction:450257] Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 [Homo sapiens]
[Reaction:3229102] p-MAPKAPK3 phosphorylates BMI1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786980] Update Tracker - [Reaction:450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - v46:[addLiteratureReference, modifyText]
[_UpdateTracker:9790192] Update Tracker - [Reaction:450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - v35:[modifyText]
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