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Details on Person Toll-like receptor 3 (TLR3) as was shown for mammals is expr...
| Class:Id | Summation:450220 |
|---|---|
| _displayName | Toll-like receptor 3 (TLR3) as was shown for mammals is expr... |
| _timestamp | 2024-02-28 21:37:23 |
| created | [InstanceEdit:450323] Shamovsky, V, 2009-12-16 |
| literatureReference | [LiteratureReference:177890] Transcriptional signaling by double-stranded RNA: role of TLR3 [LiteratureReference:177877] Toll-like receptor 3: a link between toll-like receptor, interferon and viruses |
| modified | [InstanceEdit:500571] Shamovsky, V, 2010-02-04 [InstanceEdit:500595] Shamovsky, V, 2010-02-04 [InstanceEdit:500599] Shamovsky, V, 2010-02-04 [InstanceEdit:9839808] Shamovsky, Veronica, 2023-07-10 [InstanceEdit:9863277] Shamovsky, Veronica, 2024-02-28 [InstanceEdit:9863314] Shamovsky, Veronica, 2024-02-28 |
| text | Toll-like receptor 3 (TLR3) as was shown for mammals is expressed in various tissues and cells, including myeloid dendritic cells, macrophages, respiratory and intestinal epithelium, neurons and microglial cells to induce antiviral and inflammatory responses of the innate immunity in combating viral infections. TLR3 recognizes dsRNA in the endosome and that triggers the receptor dimerization. TLR3 recruits the adaptor TRIF (TICAM1), leading to the activation of NF-kappa-B and the production of type I interferons (IFNs). dsRNA-stimulated phosphorylation of two specific TLR3 tyrosine residues (Tyr759 and Tyr858) is essential for initiating TLR3 signaling pathways. |
| (summation) | [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade [Homo sapiens] |
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