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Details on Person K63polyUb [cytosol]

Class:Id	Polymer:450152
_displayName	K63polyUb [cytosol]
_timestamp	2019-11-18 23:01:33
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450149] Jupe, S, 2009-12-16
crossReference	[DatabaseIdentifier:9667283] ChEBI:36080
minUnitCount	3
modified	[InstanceEdit:3080598] D'Eustachio, P, 2013-02-07 [InstanceEdit:3095904] D'Eustachio, P, 2013-02-08 [InstanceEdit:9667994] D'Eustachio, Peter, 2019-11-18
name	K63polyUb K63-polyubiquitin Lys-63 polyubiquitin
repeatedUnit	[DefinedSet:450143] K63-Ub [cytosol] [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1108147] R-HSA-450152.2
(hasComponent)	[Complex:847073] K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] [Homo sapiens] [Complex:936946] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] [Homo sapiens] [Complex:936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] [Homo sapiens] [Complex:936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] [Homo sapiens] [Complex:937008] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] [Homo sapiens] [Complex:937060] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] [Homo sapiens] [Complex:975099] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] [Homo sapiens] [Complex:975171] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] [Homo sapiens] [Complex:8948017] UBE2N:UBE2V1:K63polyUb [cytosol] [Homo sapiens] [Complex:9645445] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] [Homo sapiens] List all 11 refering instances
(hasMember)	[DefinedSet:5689096] PolyUb [cytosol] [Homo sapiens]
(input)	[Reaction:168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex [Homo sapiens] [Reaction:177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex [Homo sapiens] [Reaction:202453] Auto-ubiquitination of TRAF6 [Homo sapiens] [BlackBoxEvent:202534] Ubiquitination of NEMO by TRAF6 [Homo sapiens] [Reaction:688137] RIP2 is K63 polyubiquitinated [Homo sapiens] [Reaction:741386] RIP2 induces K63-linked ubiquitination of NEMO [Homo sapiens] [Reaction:918224] DDX58 is K63 polyubiquitinated [Homo sapiens] [Reaction:936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex [Homo sapiens] [Reaction:936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex [Homo sapiens] [Reaction:937050] Pellino ubiquitinates hp-IRAK1 [Homo sapiens] List all 34 refering instances
(modification)	[GroupModifiedResidue:706472] ubiquitinylated lysine (K63polyUb [cytosol]) at 209 [GroupModifiedResidue:741409] ubiquitinylated lysine (K63polyUb [cytosol]) at 285 [GroupModifiedResidue:3080561] ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position [GroupModifiedResidue:3080566] ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position [GroupModifiedResidue:3080570] ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position [GroupModifiedResidue:3080587] ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position [GroupModifiedResidue:3080588] ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 321 [GroupModifiedResidue:3080589] ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position [GroupModifiedResidue:3080590] ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 325 [GroupModifiedResidue:3080591] ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 124 List all 63 refering instances
(output)	[Polymerisation:450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation [Homo sapiens] [Reaction:688136] TNFAIP3 (A20) deubiquitinates RIP2 [Homo sapiens] [Reaction:741411] CYLD deubiquitinates NEMO [Homo sapiens] [Reaction:936381] OTUD5 deubiquitinates TRAF3 [Homo sapiens] [Polymerisation:936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains [Homo sapiens] [Reaction:5690856] TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 [Homo sapiens] [Reaction:5691439] BRISC complex deubiquitinates NLRP3 [Homo sapiens] [Reaction:5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [Homo sapiens] [Reaction:6781779] USP13 deubiquitinates BECN1,USP10 [Homo sapiens] [Reaction:6781814] USP19 deubiquitinates RNF123 [Homo sapiens] List all 16 refering instances
(updatedInstance)	[_UpdateTracker:9869568] Update Tracker - [Polymer:450152] K63polyUb [cytosol] - v34:[updateContainedRepeatedUnit] [_UpdateTracker:9874942] Update Tracker - [Polymer:450152] K63polyUb [cytosol] - v44:[addName, updateContainedRepeatedUnit]
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No pathways have been reviewed or authored by K63polyUb [cytosol] (450152)