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Details on Person MyD88 and Tollip only bind to non-phosphorylated IRAK1 (Wesc...

Class:IdSummation:450124
_displayNameMyD88 and Tollip only bind to non-phosphorylated IRAK1 (Wesc...
_timestamp2017-07-13 16:42:16
created[InstanceEdit:450128] Jupe, S, 2009-12-14
literatureReference[LiteratureReference:450126] IRAK1: a critical signaling mediator of innate immunity
[LiteratureReference:165868] MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
[LiteratureReference:451555] The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4
modified[InstanceEdit:451558] Jupe, S, 2010-01-05
[InstanceEdit:9012434] Duenas, Corina, 2017-07-13
[InstanceEdit:9733355] Wu, Guanming, 2021-06-04
textMyD88 and Tollip only bind to non-phosphorylated IRAK1 (Wesche et al. 1997) so hyper-phosphorylated IRAK1 is predisposed to release from the receptor complex, a key step in this signaling cascade. It is believed that the interaction of IRAK1 with TRAF6 enables the release of IRAK1:TRAF6 from the receptor (Gottipati et al. 2007). Though released from the receptor complex, IRAK1:TRAF6 remains associated with the membrane, perhaps due to subsequent interaction with the TAK1 complex (Dong et al. 2006). Interleukin-1 receptor-associated kinase 3 (IRAK3 or IRAK-M) prevents the dissociation of IRAK1 and IRAK4 from the MYD88 oligomeric signaling complex called the Myddosome (Kobayashi K et al. 2002).
(summation)[Reaction:446894] TRAF6 binding leads to IRAK1:TRAF6 release [Homo sapiens]
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