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Details on Person IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane]

Class:Id	Complex:450120
_displayName	IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane]
_timestamp	2017-07-13 16:41:16
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:450128] Jupe, S, 2009-12-14
hasComponent	[Complex:445758] IL1R1:IL1:IL1RAP [plasma membrane] [Homo sapiens] [Complex:445755] IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:197595] IL1R1 [plasma membrane] [Homo sapiens] [DefinedSet:445744] IL1B,Myr82K-Myr83K-IL1A [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:445745] IL1RAP-1 [plasma membrane] [Homo sapiens] [Complex:193932] MYD88 dimer [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:446679] Jupe, S, 2009-11-16 [InstanceEdit:622266] Jupe, S, 2010-04-22 [InstanceEdit:9012434] Duenas, Corina, 2017-07-13
name	IL1R1:IL1:IL1RAP:MYD88 dimer IL1:IL1R1:IL1RAP:MYD88 homodimer
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1110156] R-HSA-450120.2
(hasComponent)	[Complex:446637] IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] [Homo sapiens]
(input)	[Reaction:446648] IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 [Homo sapiens] [FailedReaction:5602583] IRAK4 deficiency blocks the formation of MyD88-IRAK4 Myddosome in IL1R pathway [Homo sapiens] [FailedReaction:5602684] Defective IRAK4 does not form complex with MyD88 within TLR7/8 complex [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:5602377] loss_of_function of MyD88 S34Y [cytosol] [EntityFunctionalStatus:5602710] loss_of_function of MyD88 L93P [cytosol] [EntityFunctionalStatus:9658480] loss_of_function of IL1R1:IL1:IL1RAP:MYD88 variant [plasma membrane]
(output)	[Reaction:446894] TRAF6 binding leads to IRAK1:TRAF6 release [Homo sapiens] [Reaction:450133] IL1R1:IL1:IL1RAP binds MYD88 homodimer [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9892674] Update Tracker - [Complex:450120] IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] - v54:[updateContainedComponent] [_UpdateTracker:9897772] Update Tracker - [Complex:450120] IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] - v62:[addName, updateContainedComponent] [_UpdateTracker:9903672] Update Tracker - [Complex:450120] IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] - v80:[updateContainedComponent]
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No pathways have been reviewed or authored by IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (450120)