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Details on Person Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2

Class:Id	Reaction:450031
_displayName	Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
_doRelease	TRUE
_timestamp	2011-09-09 08:59:26
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:450083] Jupe, S, 2009-12-11
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
input	[Complex:450048] IL3:IL3RA [plasma membrane] [Homo sapiens] [Complex:879945] IL3RB:JAK2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:450058] Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors [LiteratureReference:879957] Heterodimerization of the alpha and beta chains of the interleukin-3 (IL-3) receptor is necessary and sufficient for IL-3-induced mitogenesis
modified	[InstanceEdit:512989] Jupe, S, 2010-02-16 [InstanceEdit:879892] Jupe, S, 2010-06-25 [InstanceEdit:913398] Jupe, S, 2010-07-14 [InstanceEdit:927713] Jupe, S, 2010-08-06 [InstanceEdit:941868] Jupe, S, 2010-09-06 [InstanceEdit:1474064] Jupe, S, 2011-08-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
output	[Complex:450064] IL3:IL3RA:IL3RB:JAK2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:450074] Interleukin-3 receptor alpha subunit binds Interleukin-3 [Homo sapiens] [Reaction:879937] The common beta chain IL3RB binds JAK2 [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104814] R-HSA-450031.2
summation	[Summation:450018] The alpha subunit of the IL3 receptor binds IL 3 with low af...
(hasEvent)	[Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling [Homo sapiens]
(precedingEvent)	[Reaction:879907] Tyrosine kinases phosphorylate the receptor [Homo sapiens] [BlackBoxEvent:879942] The receptor is activated [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790148] Update Tracker - [Reaction:450031] Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 - v35:[modifyText]
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