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Details on Person The Interleukin-11 receptor alpha chain (IL11RA) belongs to ...

Class:IdSummation:449807
_displayNameThe Interleukin-11 receptor alpha chain (IL11RA) belongs to ...
_timestamp2017-05-26 10:26:27
created[InstanceEdit:449839] Jupe, S, 2009-12-07
literatureReference[LiteratureReference:449793] Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction
[LiteratureReference:449783] Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions
[LiteratureReference:449965] Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction
modified[InstanceEdit:449857] Jupe, S, 2009-12-07
[InstanceEdit:9007063] Jupe, Steve, 2017-05-26
textThe Interleukin-11 receptor alpha chain (IL11RA) belongs to the IL6 receptor family. Interleukin-11 (IL11) first interacts with IL11RA with a low affinity (Kd = 10 nM) forming an IL11:IL11RA complex which subsequently interacts with Interleukin-6 receptor beta subunit (IL6ST,gp130) forming a high-affinity (Kd = 300–800 pM) and signal-transducing complex (Yin et al. 1993, Hilton et al. 1994).
(summation)[Reaction:449829] IL11 binds IL11RA [Homo sapiens]
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