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Details on Person The IL-10 receptor is composed of at least two subunits, bot...

Class:IdSummation:449775
_displayNameThe IL-10 receptor is composed of at least two subunits, bot...
_timestamp2016-09-05 11:17:05
created[InstanceEdit:449839] Jupe, S, 2009-12-07
literatureReference[LiteratureReference:449776] Expression cloning and characterization of a human IL-10 receptor
[LiteratureReference:6783825] Characterization of interleukin-10 receptors on human and mouse cells
[LiteratureReference:6783747] Interleukin-10 and the interleukin-10 receptor
[LiteratureReference:6783856] Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation
modified[InstanceEdit:449857] Jupe, S, 2009-12-07
[InstanceEdit:6783794] Jupe, Steve, 2015-06-17
[InstanceEdit:6783804] Jupe, Steve, 2015-06-17
[InstanceEdit:6784364] Jupe, Steve, 2015-06-19
[InstanceEdit:6786759] Jupe, Steve, 2015-07-10
[InstanceEdit:8878400] Jupe, Steve, 2016-07-04
[InstanceEdit:8937645] Jupe, Steve, 2016-09-05
textThe IL-10 receptor is composed of at least two subunits, both members of the interferon receptor (IFNR) family (Liu et al. 1994). Interferon-10 receptor alpha chain (IL10RA) is the ligand-binding subunit, binding IL-10 with high affinity (Kd 35-200 pM) (Tan et al. 1993). IL10RA is constitutively associated with JAK1 (Moore et al. 2001, Usacheva et al. 2002). This association is dependent on a membrane-proximal part of the receptor (amino acids 269-274) which contain a region designated the box 2B motif, characterized by a core of four hydrophobic residues flanked by a serine and charged residues (Usacheva et al. 2002).
(summation)[Reaction:449803] IL10 dimer binds IL10RA:JAK1 [Homo sapiens]
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