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Details on Person Addition of a third mannose to the N-glycan precursor by ALG2

Class:Id	Reaction:449718
_displayName	Addition of a third mannose to the N-glycan precursor by ALG2
_doRelease	TRUE
_timestamp	2010-12-02 14:41:58
authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:449719] alpha-1,6-mannosyltransferase activity of ALG2 [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:449736] Jassal, B, 2009-12-07
edited	[InstanceEdit:449736] Jassal, B, 2009-12-07
figure	[Figure:975565] /figures/5_GlcNAc2Man3PPDol.png
inferredFrom	[Reaction:449748] Addition of a third mannose to the N-glycan precursor by Alg2 [Saccharomyces cerevisiae]
input	[SimpleEntity:449737] (GlcNAc)2 (Man)2 (PP-Dol)1 [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:162860] GDP-Man [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:449330] A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis [LiteratureReference:449740] In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis [LiteratureReference:449741] Biochemical characterization and membrane topology of Alg2 from Saccharomyces cerevisiae as a bifunctional alpha1,3- and 1,6-mannosyltransferase involved in lipid-linked oligosaccharide biosynthesis
modified	[InstanceEdit:449893] Jassal, B, 2009-12-09 [InstanceEdit:749517] Jassal, B, 2010-05-19 [InstanceEdit:916859] Jassal, B, 2010-07-29 [InstanceEdit:936937] Jassal, B, 2010-08-24 [InstanceEdit:975558] Jassal, B, 2010-09-29 [InstanceEdit:1022125] Jassal, B, 2010-11-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Addition of a third mannose to the N-glycan precursor by ALG2
output	[SimpleEntity:449243] (GlcNAc)2 (Man)3 (PP-Dol)1 [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:446208] Addition of a second mannose to the N-glycan precursor by ALG2 [Homo sapiens] [Reaction:446218] Addition of the first mannose to the N-glycan precursor by ALG1 [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:749519] Gagneux, P, 2010-04-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105938] R-HSA-449718.2
summation	[Summation:449708] A third mannose is added to the N-glycan precursor by ALG2 u...
(hasEvent)	[Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein [Homo sapiens]
(precedingEvent)	[Reaction:446187] ALG11 transfers the fourth and fifth Man to the N-glycan precursor [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782488] Update Tracker - [Reaction:449718] Addition of a third mannose to the N-glycan precursor by ALG2 - v59:[modifyText] [_UpdateTracker:9789856] Update Tracker - [Reaction:449718] Addition of a third mannose to the N-glycan precursor by ALG2 - v37:[modifyText]
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