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Details on Person GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P

Class:Id	Reaction:449715
_displayName	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P
_doRelease	TRUE
_timestamp	2024-05-15 14:48:12
authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:532207] L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity of GFPT1,2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:449736] Jassal, B, 2009-12-07
crossReference	[DatabaseIdentifier:9909161] RHEA:13238
edited	[InstanceEdit:449736] Jassal, B, 2009-12-07
input	[SimpleEntity:29512] Fru(6)P [cytosol] [SimpleEntity:29472] L-Gln [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:449721] Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase [LiteratureReference:449716] cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse [LiteratureReference:1236605] Hexosamine biosynthetic pathway mutations cause neuromuscular transmission defect
modified	[InstanceEdit:532210] Jassal, B, 2010-02-26 [InstanceEdit:532517] Jassal, B, 2010-03-01 [InstanceEdit:749517] Jassal, B, 2010-05-19 [InstanceEdit:771704] Jassal, B, 2010-05-21 [InstanceEdit:1022125] Jassal, B, 2010-11-17 [InstanceEdit:4085031] Jassal, Bijay, 2013-08-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9909163] D'Eustachio, Peter, 2024-04-29 [InstanceEdit:9910565] D'Eustachio, Peter, 2024-05-15
name	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P D-fructose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate Formation of glucosamine 6-phosphate from fructose 6-phosphate and glutamine
output	[SimpleEntity:449701] GlcN6P [cytosol] [SimpleEntity:29404] L-Glu [cytosol]
precedingEvent	[Reaction:70471] GPI dimer isomerizes G6P [Homo sapiens] [Reaction:70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P [Homo sapiens] [Reaction:5696021] ADPGK:Mg2+ phosphorylates Glc to G6P [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:749519] Gagneux, P, 2010-04-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105322] R-HSA-449715.3
summation	[Summation:449699] Glucosamine-fructose 6-phosphate aminotransferases 1 and 2 (...
(hasEvent)	[Pathway:446210] Synthesis of UDP-N-acetyl-glucosamine [Homo sapiens]
(normalReaction)	[FailedReaction:4085027] Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P [Homo sapiens]
(precedingEvent)	[Reaction:449734] Acetylation of glucosamine 6-phosphate to GlcNAc6P [Homo sapiens] [Reaction:6799604] GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784708] Update Tracker - [Reaction:449715] GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P - v53:[modifyText] [_UpdateTracker:9787225] Update Tracker - [Reaction:449715] GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P - v46:[addLiteratureReference, modifyText] [_UpdateTracker:9789570] Update Tracker - [Reaction:449715] GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P - v37:[modifyText]
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